LTBR and ZMYND11

Number of citations of the paper that reports this interaction (PubMedID 20732415)
0

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		LTBR	ZMYND11
Description		lymphotoxin beta receptor	zinc finger MYND-type containing 11
Image
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane Membrane	Nucleus Nucleoplasm Chromosome
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	DNA Binding Double-stranded DNA Binding Transcription Corepressor Activity Protein Binding Zinc Ion Binding Metal Ion Binding Histone H3K36me3 Reader Activity
	Biological Process	Apoptotic Process Immune Response Signal Transduction Myeloid Dendritic Cell Differentiation Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of JNK Cascade Hematopoietic Or Lymphoid Organ Development Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Chromatin Organization Regulation Of Signal Transduction Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of DNA-templated Transcription Negative Regulation Of JNK Cascade Defense Response To Virus Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		TNFR2 non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 23749187) Aspartate aminotransferase levels ( 33547301) Basophil count ( 32888494) Celiac disease ( 31591516) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 26192919 28067908) Eosinophil percentage of white cells ( 32888494) Granulocyte percentage of myeloid white cells ( 27863252) Inflammatory bowel disease ( 28067908) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Multiple sclerosis ( 31604244 24076602) Platelet distribution width ( 32888494) Plateletcrit ( 27863252 32888494) Primary biliary cirrhosis ( 22961000) Tonsillectomy ( 28928442 27182965) White blood cell count ( 32888494)	Malaria ( 31844061)
Interacting Genes		15 interacting genes: BIRC2 DIABLO HES1 LTA LTB MTNR1B RABAC1 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRIM37 ZMYND11	26 interacting genes: ARHGEF18 BMPR1A DYNLL1 E2F6 EMSY ETS2 EZH1 EZH2 H3-3A H3-4 H4C1 HDAC1 HOXD4 LTBR MAGEC2 MYB NCOR1 PDLIM7 SMAD2 SMAD3 SMARCA4 SRPK1 TAB1 TRAF3 TRAF6 ZHX1
Entrez ID		4055	10771
HPRD ID		02988	09830
Ensembl ID		ENSG00000111321	ENSG00000015171
Uniprot IDs		P36941	A0A0D9SGD6 A0A994J4C0 A0A994J4I8 A0A994J6Y5 B7Z2J6 E7ENI9 Q15326 Q5BJG6 Q5UGI2
PDB IDs		1RF3 4MXW	4NS5 5HDA
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Binding Regulation Of Canonical NF-kappaB Signal Transduction Thioesterase Binding CD40 Receptor Complex Regulation Of Apoptotic Process Regulation Of Programmed Cell Death Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Extrinsic Apoptotic Signaling Pathway Signaling Adaptor Activity Apoptotic Process Cell Death Programmed Cell Death Positive Regulation Of Canonical NF-kappaB Signal Transduction Cytoplasmic Side Of Plasma Membrane Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Ubiquitin Protein Ligase Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway Regulation Of Cell Communication Regulation Of Signaling Identical Protein Binding Positive Regulation Of Cell Communication Positive Regulation Of Apoptotic Signaling Pathway Ubiquitin Protein Ligase Activity Signal Transduction Regulation Of DNA-binding Transcription Factor Activity Cytokine-mediated Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Signal Transduction CD40 Signaling Pathway Interleukin-17-mediated Signaling Pathway Positive Regulation Of Signaling Positive Regulation Of NF-kappaB Transcription Factor Activity Ubiquitin-protein Transferase Activity Positive Regulation Of Apoptotic Process Zinc Ion Binding Hematopoietic Or Lymphoid Organ Development Positive Regulation Of Programmed Cell Death Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Lymph Node Development Positive Regulation Of DNA-binding Transcription Factor Activity Programmed Necrotic Cell Death Signaling Cell Communication Response To Other Organism Positive Regulation Of Protein Modification Process Positive Regulation Of Multicellular Organismal Process Regulation Of JNK Cascade	Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of Transcription By RNA Polymerase II Regulation Of Macromolecule Biosynthetic Process Regulation Of MiRNA Transcription Regulation Of Macromolecule Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Endoderm Development Regulation Of MiRNA Metabolic Process Chromatin Organization Negative Regulation Of Metabolic Process Subtelomeric Heterochromatin Formation Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Positive Regulation Of MiRNA Transcription Constitutive Heterochromatin Formation Chordate Embryonic Development Heterochromatin Formation Negative Regulation Of Androgen Receptor Signaling Pathway Cell Differentiation Embryo Development Ending In Birth Or Egg Hatching Positive Regulation Of MiRNA Metabolic Process Multicellular Organism Development Positive Regulation Of Transforming Growth Factor Beta Production RNA Polymerase II Core Promoter Sequence-specific DNA Binding Cellular Developmental Process Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Cell Differentiation Histone H3K27 Trimethyltransferase Activity Paraxial Mesoderm Morphogenesis Chromosome, Telomeric Region RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Animal Organ Morphogenesis Positive Regulation Of Macromolecule Metabolic Process
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