LTBR and TNFSF14

Number of citations of the paper that reports this interaction (PMID 9462508)
128

Data Source:
HPRD (in vitro, in vivo)

		LTBR	TNFSF14
Gene Name		lymphotoxin beta receptor (TNFR superfamily, member 3)	tumor necrosis factor (ligand) superfamily, member 14
Image
Gene Ontology Annotations	Cellular Component	Integral Component Of Membrane	Extracellular Space Cytoplasm Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
	Biological Process	Apoptotic Process Signal Transduction Viral Process Myeloid Dendritic Cell Differentiation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JNK Cascade Cellular Response To Mechanical Stimulus Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Apoptotic Process Immune Response Signal Transduction Release Of Cytoplasmic Sequestered NF-kappaB Positive Regulation Of T Cell Chemotaxis T Cell Costimulation T Cell Proliferation T Cell Activation T Cell Homeostasis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Myoblast Differentiation Cellular Response To Mechanical Stimulus Positive Regulation Of Myoblast Fusion
Pathways
Drugs
Diseases
GWAS			Multiple sclerosis ( 21833088)
Protein-Protein Interactions		13 interactors: BIRC2 DIABLO HES1 LTA LTB TNFSF14 TRAF1 TRAF2 TRAF3 TRAF4 TRAF5 TRIM37 ZMYND11	5 interactors: APP LTB LTBR TNFRSF14 TNFRSF6B
Entrez ID		4055	8740
HPRD ID		02988	05157
Ensembl ID		ENSG00000111321	ENSG00000125735
Uniprot IDs		P36941	O43557
PDB IDs		1RF3	4EN0 4J6G 4KG8 4KGG 4KGQ
Enriched GO Terms of Interacting Partners?		Regulation Of Apoptotic Process Apoptotic Process Programmed Cell Death Regulation Of Cell Death Cell Death Death Protein Ubiquitination Protein Modification By Small Protein Conjugation Positive Regulation Of NF-kappaB Transcription Factor Activity Regulation Of Sequence-specific DNA Binding Transcription Factor Activity NIK/NF-kappaB Signaling Positive Regulation Of Intracellular Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Regulation Of Cysteine-type Endopeptidase Activity Positive Regulation Of Immune System Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Regulation Of I-kappaB Kinase/NF-kappaB Signaling MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Signaling Cell Communication Regulation Of Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Protein Homodimerization Activity Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Toll-like Receptor Signaling Pathway Positive Regulation Of Signal Transduction Immune Response Regulation Of Immune System Process Cellular Response To Stimulus Positive Regulation Of Binding Lymph Node Development Regulation Of Endopeptidase Activity Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Regulation Of Protein Homodimerization Activity Regulation Of Peptidase Activity Immune System Process Activation Of NF-kappaB-inducing Kinase Activity Regulation Of Signaling Activation Of Innate Immune Response Regulation Of JNK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Stress-activated MAPK Cascade	Programmed Cell Death Cell Death Death Immune System Process Synaptic Growth At Neuromuscular Junction Collateral Sprouting In Absence Of Injury Positive Regulation Of Cellular Metabolic Process Apoptotic Process Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Cytokine Secretion Involved In Immune Response Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Positive Regulation Of Protein Metabolic Process Axon Choice Point Recognition Immune Response Negative Regulation Of Alpha-beta T Cell Proliferation Regulation Of Phosphorylation Neuron Remodeling Positive Regulation Of Metabolic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Positive Regulation Of T Cell Migration Lymph Node Development Cellular Copper Ion Homeostasis Response To External Stimulus Regulation Of T Cell Migration Regulation Of Cellular Ketone Metabolic Process Copper Ion Homeostasis Suckling Behavior Regulation Of Cytokine Production Negative Regulation Of Alpha-beta T Cell Activation Viral Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Myeloid Dendritic Cell Differentiation Myeloid Dendritic Cell Activation Neuron Maturation MRNA Polyadenylation Regulation Of Epidermal Growth Factor-activated Receptor Activity Regulation Of Lymphocyte Migration Regulation Of Protein Metabolic Process Mating Behavior Defense Response To Gram-negative Bacterium Endoplasmic Reticulum Calcium Ion Homeostasis Tumor Necrosis Factor-mediated Signaling Pathway Cell Activation
Tagcloud ?		affymetrix agilent asct canvac cgvhd dnjgb1 dusp1 egwas fosb generalizable genomics geo identifier illumina justify manifestation merged mmp2 mutual omnibus players repository resembles sepx1 ssc standalone subtraction tnfaip8 uploaded	17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck xcl1
Tagcloud (Difference) ?		affymetrix agilent asct canvac cgvhd dnjgb1 dusp1 egwas fosb generalizable genomics geo identifier illumina justify manifestation merged mmp2 mutual omnibus players repository resembles sepx1 ssc standalone subtraction tnfaip8 uploaded	17f 28a 6ckine ccl13 ccl14 ccl16 ccl17 ccl18 ccl19 ccl21 ccl22 ccl23 ccl25 ccl26 ccl27 ccl28 ccl7 ccl8 ctack cxcl11 cxcl3 cxcl7 il18 lymphotactin mpif parc tarc teck xcl1
Tagcloud (Intersection) ?