LTA and TNFRSF1B

Number of citations of the paper that reports this interaction (PubMedID 2160731)
0

Data Source:
HPRD (in vivo)

		LTA	TNFRSF1B
Description		lymphotoxin alpha	TNF receptor superfamily member 1B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Membrane	Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Plasma Membrane Membrane Specific Granule Membrane Membrane Raft
	Molecular Function	Signaling Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding Protein Binding	Tumor Necrosis Factor Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Immune Response Humoral Immune Response Cell Communication Signal Transduction Cell Surface Receptor Signaling Pathway Cell-cell Signaling Response To Nutrient Response To Xenobiotic Stimulus Signaling Response To Lipopolysaccharide Positive Regulation Of Type II Interferon Production Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Cytokine Production Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Apoptotic Process Inflammatory Response Cell Surface Receptor Signaling Pathway Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Myelination Positive Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation Negative Regulation Of Inflammatory Response RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Cellular Response To Lipopolysaccharide Extrinsic Apoptotic Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Glial Cell-neuron Signaling Positive Regulation Of Apoptotic Process Involved In Morphogenesis
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway	TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs		Etanercept	Tasonermin
Diseases			Graft-versus-host disease
GWAS		A body shape index ( 34021172) Asthma ( 31619474) Asthma (childhood onset) ( 31619474) Asthma and major depressive disorder ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 21102463) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Kawasaki disease ( 33106546) Lymphocyte count ( 27863252 32888494) Lymphocyte percentage of white cells ( 27863252 32888494) Malaria ( 31844061) Monocyte count ( 32888494) Neonatal lupus ( 20662065) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Tumor necrosis factor levels ( 32805626) Type 1 diabetes and autoimmune thyroid diseases ( 25936594) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172) White blood cell count ( 27863252)	Asthma ( 31959851) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Tuberculosis ( 29036319) Urate levels (BMI interaction) ( 25811787)
Interacting Genes		13 interacting genes: ABHD16A ASPH CREB3 LGALS2 LTB LTBR SLC30A2 TMEM237 TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD	21 interacting genes: BMX CAV1 CD14 CSNK1A1 CSNK1A1L FANCD2 FOXP1 HIVEP3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420
Entrez ID		4049	7133
HPRD ID		01084	01862
Ensembl ID		ENSG00000226979	ENSG00000028137
Uniprot IDs		P01374 Q5ST95 Q5STV3 Q6FG55	P20333
PDB IDs		1TNR 4MXV 4MXW	1CA9 3ALQ 8HLB 9CU8
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor Receptor Activity Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Extracellular Matrix Constituent Secretion Pulmonary Valve Development Tumor Necrosis Factor Receptor Superfamily Complex Aortic Valve Development Semi-lunar Valve Development Positive Regulation Of Apoptotic Process Involved In Morphogenesis Tumor Necrosis Factor Binding Positive Regulation Of Apoptotic Process Involved In Development Regulation Of Extracellular Matrix Constituent Secretion Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Heart Valve Development Negative Regulation Of Extracellular Matrix Organization Cytokine-mediated Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Programmed Cell Death Negative Regulation Of Muscle Hypertrophy Regulation Of Muscle System Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Citric Acid Secretion Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle Positive Regulation Of Deacetylase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Peptidyl-aspartic Acid 3-dioxygenase Activity Plasma Membrane Membrane Galectin Complex Ubiquitin Protein Ligase Binding Cellular Response To Mechanical Stimulus Regulation Of Extracellular Matrix Organization Defense Response To Bacterium Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cardiac Muscle Hypertrophy Metanephric Thick Ascending Limb Development Protein Transport Into Plasma Membrane Raft Micturition Phosphatidylserine Catabolic Process Prostaglandin Catabolic Process Negative Regulation Of Adaptive Immune Memory Response Regulation Of Canonical NF-kappaB Signal Transduction Apoptotic Signaling Pathway Response To Unfolded Protein Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Juxtaglomerular Apparatus Development Defense Response To Gram-negative Bacterium	Tumor Necrosis Factor Receptor Binding Tumor Necrosis Factor-mediated Signaling Pathway Cell Death Programmed Cell Death Regulation Of Immune Response Apoptotic Process Regulation Of Immune System Process Regulation Of Canonical NF-kappaB Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Signal Transduction Thioesterase Binding Regulation Of Defense Response Cytokine-mediated Signaling Pathway Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Immune Response Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Cytokine Production Signal Transduction Regulation Of Apoptotic Process Regulation Of Cytokine Production Regulation Of Programmed Cell Death Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Chronic Inflammatory Response Aggresome Regulation Of Intracellular Signal Transduction Regulation Of Macromolecule Metabolic Process Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Immune System Process Positive Regulation Of Macromolecule Metabolic Process Regulation Of Type I Interferon Production Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Stress Cell Surface Toll-like Receptor Signaling Pathway Positive Regulation Of Apoptotic Signaling Pathway Cell Surface Pattern Recognition Receptor Signaling Pathway Negative Regulation Of Endothelial Cell Proliferation Pattern Recognition Receptor Signaling Pathway Regulation Of Chronic Inflammatory Response Regulation Of Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Metabolic Process Immune Response-activating Signaling Pathway Innate Immune Response-activating Signaling Pathway Regulation Of Gene Expression Regulation Of Nitric Oxide Metabolic Process Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Gene Expression
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