LTA and TNFRSF14

Number of citations of the paper that reports this interaction (PMID 9462508)
128

Data Source:
HPRD (in vitro)

		LTA	TNFRSF14
Gene Name		lymphotoxin alpha	tumor necrosis factor receptor superfamily, member 14
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Virus Receptor Activity Tumor Necrosis Factor-activated Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Humoral Immune Response Signal Transduction Cell-cell Signaling Response To Nutrient Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation	Positive Regulation Of Cytokine Secretion Involved In Immune Response Immune Response Cell Surface Receptor Signaling Pathway Response To Virus Viral Process T Cell Costimulation Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Positive Regulation Of T Cell Migration
Pathways			Costimulation by the CD28 family Adaptive Immune System
Drugs		Etanercept
Diseases
GWAS		Crohn's disease ( 21102463) Neonatal lupus ( 20662065)	Celiac disease ( 20190752) Rheumatoid arthritis ( 18794853 20453842) Ulcerative colitis ( 23128233 21297633)
Protein-Protein Interactions		8 interactors: LGALS2 LTB LTBR TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD	30 interactors: A2M APP BTLA CD160 CHD3 DGKD DRAP1 DYNLL1 ESR1 HDAC3 HDAC4 IMPA2 ITFG1 KIAA1377 LTA MBTPS1 NDUFS2 NRIP1 RAD21 SERPINA4 TNFSF13 TNFSF14 TRAF1 TRAF2 TRAF3 TRAF5 UBQLN4 VIM WDR73 ZBTB48
Entrez ID		4049	8764
HPRD ID		01084	04122
Ensembl ID		ENSG00000226979	ENSG00000157873
Uniprot IDs		P01374 Q5STV3	Q92956
PDB IDs		1TNR	1JMA 2AW2 4FHQ
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus Response To Cytokine Programmed Cell Death Positive Regulation Of Cytokine Production Immune System Process Cell Death Death Cellular Response To Mechanical Stimulus Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Bacterium Defense Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cytokine Production Viral Process Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response Metanephric Thick Ascending Limb Development Response To Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Other Organism Response To Biotic Stimulus Response To External Stimulus Positive Regulation Of Metabolic Process Response To Stress Cellular Response To Organic Substance Metanephric Ascending Thin Limb Development Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intrinsic Apoptotic Signaling Pathway Defense Response To Bacterium Positive Regulation Of Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Response To Mechanical Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Metanephric Distal Convoluted Tubule Development Metanephric Loop Of Henle Development Regulation Of Protein Metabolic Process Apoptotic Process Negative Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Metanephric Distal Tubule Development Cellular Response To Stimulus Regulation Of Inflammatory Response Positive Regulation Of Cellular Protein Metabolic Process	Signal Transduction Apoptotic Process Programmed Cell Death Signaling Cell Communication Cell Death Death Cellular Response To Stimulus Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Cellular Process Response To Stimulus Regulation Of Metabolic Process Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Regulation Of Proteolysis Regulation Of Nitrogen Compound Metabolic Process Regulation Of Apoptotic Process Regulation Of Cell Death Regulation Of Immune Response Regulation Of Endopeptidase Activity Regulation Of Immune System Process Regulation Of Peptidase Activity Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Protein Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Transcription Factor Import Into Nucleus Response To Stress Negative Regulation Of Endopeptidase Activity Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Peptidase Activity Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Positive Regulation Of Cell Activation Histone H4 Deacetylation Positive Regulation Of NF-kappaB Transcription Factor Activity Spindle Organization Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Immune System Process Immune System Process Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Protein Binding Negative Regulation Of Proteolysis Positive Regulation Of Adaptive Immune Response Positive Regulation Of Immunoglobulin Mediated Immune Response Histone H3 Deacetylation Negative Regulation Of Protein Processing Regulation Of Transcription From RNA Polymerase II Promoter Histone H3-K9 Modification Regulation Of Establishment Of Protein Localization
Tagcloud ?		acetate azurophilic bactericidal bpi c5a elastase ex fmlp granule inducers lasted leukocytes lipopolysaccharide lipoteichoic magnitude mediator microbial myristate permeability phorbol pmnl polymorphonuclear potently release released started stored stz zymosan	aberrations additional advances approaches biological closely contribute crebbp ep300 epha7 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology translocation understanding unique
Tagcloud (Difference) ?		acetate azurophilic bactericidal bpi c5a elastase ex fmlp granule inducers lasted leukocytes lipopolysaccharide lipoteichoic magnitude mediator microbial myristate permeability phorbol pmnl polymorphonuclear potently release released started stored stz zymosan	aberrations additional advances approaches biological closely contribute crebbp ep300 epha7 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma mef2b microenvironment mll2 pathogenesis recognized recurrent technology translocation understanding unique
Tagcloud (Intersection) ?