LTA and LGALS2

Number of citations of the paper that reports this interaction (PMID 15129282)
36

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		LTA	LGALS2
Gene Name		lymphotoxin alpha	lectin, galactoside-binding, soluble, 2
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Membrane
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Galactoside Binding Carbohydrate Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Humoral Immune Response Signal Transduction Cell-cell Signaling Response To Nutrient Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation
Pathways
Drugs		Etanercept
Diseases
GWAS		Crohn's disease ( 21102463) Neonatal lupus ( 20662065)	Response to antidepressant treatment ( 22041458)
Protein-Protein Interactions		8 interactors: LGALS2 LTB LTBR TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD	6 interactors: APP IKBKG LTA SDCBP SDCBP2 TUBA4A
Entrez ID		4049	3957
HPRD ID		01084	08859
Ensembl ID		ENSG00000226979	ENSG00000100079
Uniprot IDs		P01374 Q5STV3	P05162
PDB IDs		1TNR	1HLC
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus Response To Cytokine Programmed Cell Death Positive Regulation Of Cytokine Production Immune System Process Cell Death Death Cellular Response To Mechanical Stimulus Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Bacterium Defense Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cytokine Production Viral Process Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response Metanephric Thick Ascending Limb Development Response To Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Other Organism Response To Biotic Stimulus Response To External Stimulus Positive Regulation Of Metabolic Process Response To Stress Cellular Response To Organic Substance Metanephric Ascending Thin Limb Development Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intrinsic Apoptotic Signaling Pathway Defense Response To Bacterium Positive Regulation Of Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Response To Mechanical Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Metanephric Distal Convoluted Tubule Development Metanephric Loop Of Henle Development Regulation Of Protein Metabolic Process Apoptotic Process Negative Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Metanephric Distal Tubule Development Cellular Response To Stimulus Regulation Of Inflammatory Response Positive Regulation Of Cellular Protein Metabolic Process	Establishment Of Localization In Cell Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Cellular Localization Platelet Degranulation Response To External Stimulus Cellular Response To Stimulus Synaptic Growth At Neuromuscular Junction Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Collateral Sprouting In Absence Of Injury Positive Regulation Of Extracellular Vesicular Exosome Assembly Platelet Activation Intracellular Receptor Signaling Pathway Nervous System Development Collateral Sprouting Axon Midline Choice Point Recognition Apoptotic Process Programmed Cell Death Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Regulation Of Extracellular Vesicular Exosome Assembly Cell Death Death Axon Choice Point Recognition Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Stimulus Neuron Remodeling Signal Transduction Positive Regulation Of Exosomal Secretion Regulation Of Exosomal Secretion Immune Response Regulation Of Phosphorylation Exocytosis Substrate-dependent Cell Migration, Cell Extension Defense Response Positive Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Cytokine Production Regulation Of Chronic Inflammatory Response Signaling Positive Regulation Of Glial Cell Proliferation Axon Guidance Cell Communication Regulation Of Phosphorus Metabolic Process Lymph Node Development Positive Regulation Of Humoral Immune Response Blood Coagulation Intracellular Transport Cellular Copper Ion Homeostasis Hemostasis Generation Of Neurons Positive Regulation Of MAPK Cascade
Tagcloud ?		acetate azurophilic bactericidal bpi c5a elastase ex fmlp granule inducers lasted leukocytes lipopolysaccharide lipoteichoic magnitude mediator microbial myristate permeability phorbol pmnl polymorphonuclear potently release released started stored stz zymosan
Tagcloud (Difference) ?		acetate azurophilic bactericidal bpi c5a elastase ex fmlp granule inducers lasted leukocytes lipopolysaccharide lipoteichoic magnitude mediator microbial myristate permeability phorbol pmnl polymorphonuclear potently release released started stored stz zymosan
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