LTA and LTB

Number of citations of the paper that reports this interaction (PMID 7916655)
66

Data Source:
HPRD (in vivo, in vitro)

		LTA	LTB
Gene Name		lymphotoxin alpha	lymphotoxin beta (TNF superfamily, member 3)
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Membrane	Cellular_component Extracellular Space Integral Component Of Membrane
	Molecular Function	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding	Receptor Binding Cytokine Activity Tumor Necrosis Factor Receptor Binding
	Biological Process	Response To Hypoxia Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Apoptotic Process Humoral Immune Response Signal Transduction Cell-cell Signaling Response To Nutrient Response To Lipopolysaccharide Positive Regulation Of Interferon-gamma Production Response To Drug Positive Regulation Of Apoptotic Process Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Fibroblast Proliferation Lymph Node Development Defense Response To Gram-positive Bacterium Positive Regulation Of Glial Cell Proliferation	Immune Response Signal Transduction Cell-cell Signaling Gene Expression Skin Development Positive Regulation Of Interleukin-12 Biosynthetic Process Lymph Node Development
Pathways
Drugs		Etanercept
Diseases
GWAS		Crohn's disease ( 21102463) Neonatal lupus ( 20662065)	AIDS progression ( 19115949) Crohn's disease ( 21102463) Neonatal lupus ( 20662065)
Protein-Protein Interactions		8 interactors: LGALS2 LTB LTBR TNFRSF14 TNFRSF1A TNFRSF1B TUBA4A UMOD	4 interactors: LTA LTBR TNFRSF1A TNFSF14
Entrez ID		4049	4050
HPRD ID		01084	02987
Ensembl ID		ENSG00000226979	ENSG00000227507
Uniprot IDs		P01374 Q5STV3	Q06643 Q5STB2
PDB IDs		1TNR
Enriched GO Terms of Interacting Partners?		Tumor Necrosis Factor-mediated Signaling Pathway Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus Response To Cytokine Programmed Cell Death Positive Regulation Of Cytokine Production Immune System Process Cell Death Death Cellular Response To Mechanical Stimulus Cytokine-mediated Signaling Pathway Positive Regulation Of Protein Metabolic Process Response To Organic Substance Positive Regulation Of Cellular Metabolic Process Response To Bacterium Defense Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Cytokine Production Viral Process Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Inflammatory Response Metanephric Thick Ascending Limb Development Response To Stimulus Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Other Organism Response To Biotic Stimulus Response To External Stimulus Positive Regulation Of Metabolic Process Response To Stress Cellular Response To Organic Substance Metanephric Ascending Thin Limb Development Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Intrinsic Apoptotic Signaling Pathway Defense Response To Bacterium Positive Regulation Of Phosphorylation Regulation Of Peptidyl-tyrosine Phosphorylation Response To Mechanical Stimulus Regulation Of I-kappaB Kinase/NF-kappaB Signaling Metanephric Distal Convoluted Tubule Development Metanephric Loop Of Henle Development Regulation Of Protein Metabolic Process Apoptotic Process Negative Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Metanephric Distal Tubule Development Cellular Response To Stimulus Regulation Of Inflammatory Response Positive Regulation Of Cellular Protein Metabolic Process See more	Cellular Response To Mechanical Stimulus Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Process Response To Mechanical Stimulus Programmed Cell Death Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cell Death Death Response To Abiotic Stimulus Regulation Of Apoptotic Process Regulation Of Cell Death Response To External Stimulus Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Inflammatory Response Positive Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Import Into Nucleus Positive Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Defense Response To Bacterium Regulation Of Protein Localization To Nucleus Regulation Of Nucleocytoplasmic Transport Positive Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Release Of Cytoplasmic Sequestered NF-kappaB Regulation Of Inflammatory Response Response To Hypoxia Response To Lipopolysaccharide Positive Regulation Of Chronic Inflammatory Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Response To Molecule Of Bacterial Origin Positive Regulation Of Protein Transport Positive Regulation Of Cytokine Production Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of T Cell Chemotaxis Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus, Translocation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Intracellular Transport Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Chronic Inflammatory Response Response To Bacterium Signal Transduction Leukocyte Activation Positive Regulation Of Glial Cell Proliferation See more
Tagcloud ?		acetate azurophilic bactericidal bpi c5a elastase ex fmlp granule inducers lasted leukocytes lipopolysaccharide lipoteichoic magnitude mediator microbial myristate permeability phorbol pmnl polymorphonuclear potently release released started stored stz zymosan	31p anova burdens cachexia fall fisher fructose gluconeogenic hepatic infused infusion inoculated inorganic methylcholanthrene monitored mrs noninvasively permit phosphomonoesters pi pme prefructose reflecting remote return returned seventeen triphosphate tumour
Tagcloud (Difference) ?		acetate azurophilic bactericidal bpi c5a elastase ex fmlp granule inducers lasted leukocytes lipopolysaccharide lipoteichoic magnitude mediator microbial myristate permeability phorbol pmnl polymorphonuclear potently release released started stored stz zymosan	31p anova burdens cachexia fall fisher fructose gluconeogenic hepatic infused infusion inoculated inorganic methylcholanthrene monitored mrs noninvasively permit phosphomonoesters pi pme prefructose reflecting remote return returned seventeen triphosphate tumour
Tagcloud (Intersection) ?