CCSER1 and NDEL1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, two hybrid)

		CCSER1	NDEL1
Description		coiled-coil serine rich protein 1	nudE neurodevelopment protein 1 like 1
Image		No pdb structure
GO Annotations	Cellular Component		Chromosome, Centromeric Region Kinetochore Chromosome Cytoplasm Centrosome Microtubule Organizing Center Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Microtubule Associated Complex Synaptic Vesicle Axon Cell Leading Edge Axon Hillock Neurofilament Cytoskeleton Axon Cytoplasm
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding Identical Protein Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process		Establishment Of Mitotic Spindle Orientation Microtubule Cytoskeleton Organization Neuron Migration Inner Cell Mass Cell Proliferation Microtubule Nucleation Chromosome Segregation Mitotic Centrosome Separation Nervous System Development Retrograde Axonal Transport Insulin Receptor Signaling Pathway Regulation Of Neuron Projection Development Cell Migration Cerebral Cortex Radially Oriented Cell Migration Central Nervous System Neuron Axonogenesis Cell Differentiation Lysosome Localization Regulation Of Intracellular Protein Transport Positive Regulation Of GTPase Activity Vesicle Transport Along Microtubule Chromosome Localization Centrosome Localization Neurofilament Cytoskeleton Organization Radial Glia-guided Pyramidal Neuron Migration Positive Regulation Of Ruffle Assembly Neuron Projection Extension
Pathways			Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Apolipoprotein A1 levels ( 32203549) Chronic kidney disease ( 31015462) Cognitive function in longevity ( 33607172) Depressive symptom improvement ( 30468137) Fasting glucose ( 33381925) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels ( 32203549) Hip circumference ( 28552196) Methadone dose in opioid dependence ( 28115739) Risky sexual behaviors (alcohol dependence interaction) ( 28990359) Treatment resistant depression ( 30468137) Weight ( 28552196)
Interacting Genes		6 interacting genes: FBXL17 HSF2BP LMO3 MAPRE1 MAPRE3 NDEL1	85 interacting genes: ABI3 ACTB AIMP2 AKAP9 ANK2 APP BMI1 BORCS6 BRK1 CASK CCDC88A CCSER1 CDK5 CENPF CEP170 CEP55 CEP63 CWF19L2 DISC1 DIXDC1 DTNB DYNC1H1 DYNLL1 FXR2 GOLGA2 IMMT KALRN KIF19 KIF2C KIF5A KIFC3 KLC4 LUC7L2 MAGEA11 MBIP MED11 MIS18A MLLT10 MRC2 MTUS2 MYO5A NDC80 PAFAH1B1 PARD6G PARVG PICK1 PKP2 PRC1 RBM10 RBM14 RBM5 RPA2 SLAIN1 SNAPC5 SNX6 SYNE1 TACC3 TRAF3IP3 TUBB USP2 XPA YWHAE YWHAG ZC2HC1C ZNF10 ZNF12 ZNF17 ZNF180 ZNF197 ZNF211 ZNF230 ZNF250 ZNF260 ZNF264 ZNF3 ZNF35 ZNF417 ZNF490 ZNF544 ZNF572 ZNF599 ZNF662 ZNF707 ZNF844 ZNF91
Entrez ID		401145	81565
HPRD ID		17561	06340
Ensembl ID		ENSG00000184305	ENSG00000166579
Uniprot IDs		Q9C0I3	A6NIZ0 Q9GZM8
PDB IDs			2V66
Enriched GO Terms of Interacting Partners?		Mitotic Spindle Astral Microtubule End Microtubule Organizing Center Protein Localization To Microtubule Microtubule Plus-end Microtubule Plus-end Binding Protein Serine/threonine Kinase Binding Spindle Midzone Microtubule Binding Establishment Of Mitotic Spindle Orientation Establishment Of Spindle Orientation Establishment Of Mitotic Spindle Localization Protein Localization To Cytoskeleton Establishment Of Spindle Localization Cytoplasmic Microtubule Microtubule Spindle Localization Regulation Of Microtubule Polymerization Microtubule Cytoskeleton Organization Protein Localization To Astral Microtubule Spindle Assembly Regulation Of Microtubule Polymerization Or Depolymerization Protein Localization To Mitotic Spindle Protein Localization To Spindle Microtubule Positive Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Neurofilament Cytoskeleton Microtubule Cytoskeleton Organization Involved In Mitosis Cortical Microtubule Cytoskeleton Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Microtubule-based Process Microtubule End Radial Glia-guided Pyramidal Neuron Migration Mitotic Centrosome Separation Female Meiosis I Axon Hillock Spindle Neuron To Neuron Synapse Double-strand Break Repair Involved In Meiotic Recombination Regulation Of Microtubule-based Process Cytoskeleton Organization Establishment Of Organelle Localization Microtubule Cytoskeleton Positive Regulation Of Peroxisome Proliferator Activated Receptor Signaling Pathway Neurofilament Cytoskeleton Organization Membraneless Organelle Assembly Neural Crest Cell Differentiation Centrosome Separation Cell Projection Membrane Cytoplasm Positive Regulation Of Cellular Component Organization	Microtubule-based Process Cytoskeleton Microtubule Cell Division Kinesin Complex Microtubule Binding Microtubule Cytoskeleton Organization Cytoskeleton Organization Centrosome Nucleus Regulation Of Transcription By RNA Polymerase II Zinc Ion Binding Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Metabolic Process Identical Protein Binding Regulation Of RNA Biosynthetic Process DNA Binding Cytoskeleton-dependent Intracellular Transport Regulation Of Primary Metabolic Process Regulation Of Macromolecule Metabolic Process Maintenance Of Location In Cell Organelle Organization Kinesin Binding Maintenance Of Location Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Cytoplasmic Microtubule Organization Organelle Localization Acetylcholine Receptor Activator Activity Microtubule-based Movement Regulation Of Heart Rate By Cardiac Conduction Metal Ion Binding Establishment Of Organelle Localization Regulation Of Cell Cycle Microtubule Organizing Center Organization Central Region Of Growth Cone Protein Binding Cardiac Conduction Protein Kinase C Binding Retrograde Axonal Transport Presynapse Kinetochore Supramolecular Fiber Organization Maintenance Of Protein Location In Cell Spindle Organization Regulation Of Microtubule Cytoskeleton Organization Cytoplasmic Microtubule Microtubule Motor Activity
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