FADS1 and XRN1

Number of citations of the paper that reports this interaction (PMID 15231747)
44

Data Source:
BioGRID (two hybrid)

		FADS1	XRN1
Gene Name		fatty acid desaturase 1	5-3 exoribonuclease 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Cytoplasmic MRNA Processing Body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Membrane Intermediate Filament Cytoskeleton
	Molecular Function	C-5 Sterol Desaturase Activity Iron Ion Binding Oxidoreductase Activity Heme Binding	DNA Binding Exonuclease Activity Protein Binding Poly(A) RNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Unsaturated Fatty Acid Biosynthetic Process Cell-cell Signaling Phospholipid Biosynthetic Process Cellular Response To Starvation Unsaturated Fatty Acid Metabolic Process Alpha-linolenic Acid Metabolic Process Linoleic Acid Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Cell Differentiation Icosanoid Biosynthetic Process Oxidation-reduction Process	Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process Gene Expression RRNA Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear MRNA Surveillance Histone MRNA Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism alpha-linolenic acid (ALA) metabolism Metabolism of lipids and lipoproteins alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Linoleic acid (LA) metabolism Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)	Regulation of mRNA stability by proteins that bind AU-rich elements mRNA decay by 5' to 3' exoribonuclease Tristetraprolin (TTP) destabilizes mRNA Deadenylation-dependent mRNA decay Butyrate Response Factor 1 (BRF1) destabilizes mRNA
Drugs		Alpha-Linolenic Acid Icosapent
Diseases
GWAS		Cholesterol, total ( 20686565) Comprehensive strength and appendicular lean mass ( 22960237) Crohn's disease ( 21102463) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 20864672 19060906 20686565) Heart rate ( 23583979) Hematology traits ( 23303382) Inflammatory bowel disease ( 23128233) LDL cholesterol ( 19060910 20686565) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic syndrome ( 20694148) Metabolic traits ( 21886157) Metabolite levels ( 23281178 23378610 22916037 20037589 19043545) Oleic acid (18:1n-9) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Phospholipid levels (plasma) ( 21829377 22359512) Response to statin therapy ( 20339536) Resting heart rate ( 20639392) Sphingolipid levels ( 22359512) Stearic acid (18:0) plasma levels ( 23362303) Triglycerides ( 20864672 19060906 20686565)
Protein-Protein Interactions		1 interactors: XRN1	62 interactors: ALDOA ANGPTL6 AP1G2 ATP5G2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CD97 CENPBD1 CHD4 CTSB CTSH DCP1A DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 GLMP HEATR1 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MFSD5 MTCH2 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF187 SDHB SKIV2L SKIV2L2 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPAL ZFP36
Entrez ID		3992	54464
HPRD ID		06935	10470
Ensembl ID		ENSG00000149485	ENSG00000114127
Uniprot IDs		O60427	Q8IZH2
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process RRNA Catabolic Process Histone MRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process NcRNA Metabolic Process MRNA Metabolic Process	RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process MRNA Metabolic Process Cellular Macromolecule Catabolic Process Aromatic Compound Catabolic Process Catabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cellular Nitrogen Compound Metabolic Process Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process RRNA Processing RNA Processing RRNA Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Metabolic Process Generation Of Precursor Metabolites And Energy Ribosome Biogenesis Cellular Metabolic Process Respiratory Electron Transport Chain Electron Transport Chain RNA Splicing RNA Localization RNA Export From Nucleus Gene Expression Cellular Respiration MRNA Processing Energy Derivation By Oxidation Of Organic Compounds Ribonucleoprotein Complex Biogenesis Cellular Process Nuclear MRNA Surveillance Metabolic Process Nuclear Export MRNA Transport RNA Surveillance MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Histone MRNA Catabolic Process ATP Metabolic Process Dosage Compensation By Inactivation Of X Chromosome Cellular Response To Thyroid Hormone Stimulus RNA Transport RNA Destabilization Dosage Compensation MRNA Export From Nucleus Posttranscriptional Regulation Of Gene Expression
Tagcloud ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4	alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2
Tagcloud (Difference) ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4	alters artificial avirulence bisexual capsule changing constantly coordinated corresponds cryptococcosis cryptococcus encountering environments exonuclease habitat impairs interdependent invertebrate lac1 mating melanin neoformans opportunistic rrp44 uni virulence xrn1delta xrn1p xrn2
Tagcloud (Intersection) ?