FADS1

Gene Name		fatty acid desaturase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	C-5 Sterol Desaturase Activity Iron Ion Binding Oxidoreductase Activity Heme Binding
	Biological Process	Regulation Of Transcription, DNA-templated Unsaturated Fatty Acid Biosynthetic Process Cell-cell Signaling Phospholipid Biosynthetic Process Cellular Response To Starvation Unsaturated Fatty Acid Metabolic Process Alpha-linolenic Acid Metabolic Process Linoleic Acid Metabolic Process Cellular Lipid Metabolic Process Small Molecule Metabolic Process Regulation Of Cell Differentiation Icosanoid Biosynthetic Process Oxidation-reduction Process
Pathways		PPARA activates gene expression Fatty acid, triacylglycerol, and ketone body metabolism alpha-linolenic acid (ALA) metabolism Metabolism of lipids and lipoproteins alpha-linolenic (omega3) and linoleic (omega6) acid metabolism Linoleic acid (LA) metabolism Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)
Drugs		Alpha-Linolenic Acid Icosapent
Diseases
GWAS		Cholesterol, total ( 20686565) Comprehensive strength and appendicular lean mass ( 22960237) Crohn's disease ( 21102463) Fasting glucose-related traits ( 20081858) Fasting glucose-related traits (interaction with BMI) ( 22581228) HDL cholesterol ( 20864672 19060906 20686565) Heart rate ( 23583979) Hematology traits ( 23303382) Inflammatory bowel disease ( 23128233) LDL cholesterol ( 19060910 20686565) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 22001757) Metabolic syndrome ( 20694148) Metabolic traits ( 21886157) Metabolite levels ( 23281178 23378610 22916037 20037589 19043545) Oleic acid (18:1n-9) plasma levels ( 23362303) Palmitoleic acid (16:1n-7) plasma levels ( 23362303) Phospholipid levels (plasma) ( 21829377 22359512) Response to statin therapy ( 20339536) Resting heart rate ( 20639392) Sphingolipid levels ( 22359512) Stearic acid (18:0) plasma levels ( 23362303) Triglycerides ( 20864672 19060906 20686565)
Protein-protein Interactions		1 interactors: XRN1
Entrez ID		3992
HPRD ID		06935
Ensembl ID		ENSG00000149485
Uniprot IDs		O60427
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear MRNA Surveillance RNA Surveillance Histone MRNA Catabolic Process RRNA Catabolic Process Histone MRNA Metabolic Process Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RRNA Metabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process RNA Catabolic Process Nucleic Acid Phosphodiester Bond Hydrolysis Aromatic Compound Catabolic Process NcRNA Metabolic Process MRNA Metabolic Process
Tagcloud ?		abca1 abcg5 abcg8 atorvastatin causal challenging chow excised gwas hfd hypertensive list loci lpl madd nominally nr1h3 orthologs overlapped pcsk9 pltp qpcr qtl responded spontaneously stac3 staged suggestive timd4