FADS1

Description		fatty acid desaturase 1
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	C-5 Sterol Desaturase Activity Acyl-CoA 6-desaturase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Oxidation Of A Pair Of Donors Resulting In The Reduction Of Molecular Oxygen To Two Molecules Of Water Omega-6 Fatty Acid Desaturase Activity Acyl-CoA (8-3)-desaturase Activity
	Biological Process	Regulation Of DNA-templated Transcription Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Unsaturated Fatty Acid Biosynthetic Process Cell-cell Signaling Phospholipid Biosynthetic Process Cellular Response To Starvation Alpha-linolenic Acid Metabolic Process Long-chain Fatty Acid Biosynthetic Process Linoleic Acid Metabolic Process Regulation Of Cell Differentiation Icosanoid Biosynthetic Process
Pathways		PPARA activates gene expression Linoleic acid (LA) metabolism alpha-linolenic acid (ALA) metabolism
Drugs		alpha-Linolenic acid Icosapent
Diseases
GWAS		Alanine transaminase levels ( 29403010) Aortic valve stenosis ( 32186652) Appendicular lean mass ( 33097823) Asthma ( 31619474 31959851 32296059 34103634) Asthma (adult onset) ( 31036433) Bipolar disorder ( 28115744 31043756) Bipolar I disorder ( 31043756) Brain morphology (MOSTest) ( 32665545) Breast milk fatty acid composition (infant genotype effect) ( 29514873) Breast milk fatty acid composition (maternal genotype effect) ( 29514873) C-reactive protein levels or HDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Change in serum metabolite levels ( 31636271) Change in serum metabolite levels (CMS) ( 31636271) Cholesterol, total ( 20686565 24097068 25961943) Colorectal cancer ( 24836286) Colorectal cancer or advanced adenoma ( 30510241) Comprehensive strength and appendicular lean mass ( 22960237) Crohn's disease ( 21102463 28067908) Delta-5 desaturase activity response to n3-polyunsaturated fat supplement ( 29246731) Eosinophil count ( 27863252) Fasting blood glucose ( 20081858 22581228 25631608) Fasting blood glucose (BMI interaction) ( 22581228) Fatty acid desaturase activity (adipose tissue) ( 30453627) Fatty acid desaturase activity (serum) ( 30453627) Glycated hemoglobin levels ( 34059833) Gondoic acid (20:1n-9) levels ( 28298293) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol ( 19060906 20686565 20864672 24097068 25961943) HDL cholesterol levels ( 28334899) Heart rate ( 23583979) Height ( 25429064) Hematology traits ( 23303382) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High density lipoprotein cholesterol levels ( 29615537) Homeostasis model assessment of beta-cell function ( 20081858) Inflammatory bowel disease ( 23128233) Iron status biomarkers (total iron binding capacity) ( 33536631) Laryngeal squamous cell carcinoma ( 25194280) LDL cholesterol ( 19060910 20686565 24097068 25961943 30275531) LDL cholesterol levels ( 28334899) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 22286219) Liver enzyme levels (alkaline phosphatase) ( 22001757 33972514) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin concentration ( 32888494) Mean platelet volume ( 27863252 32888494) Mean spheric corpuscular volume ( 32888494) Metabolic syndrome ( 20694148) Metabolic traits ( 21886157) Metabolite levels ( 19043545 20037589 22916037 23281178 23378610 23823483) Metabolite risk score for predicting weight gain ( 31560688) Monocyte percentage of white cells ( 27863252 32888494) Moyamoya disease ( 29273593) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494) Oleic acid (18:1n-9) levels ( 23362303 28298293) Palmitoleic acid (16:1n-7) levels ( 23362303 28298293) Phospholipid levels (plasma) ( 22359512) Plasma omega-3 polyunsaturated fatty acid level (eicosapentaenoic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid) ( 21829377) Plasma omega-3 polyunsaturated fatty acid levels (docosapentaenoic acid) ( 21829377) Plasma omega-6 polyunsaturated fatty acid levels (adrenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid) ( 24823311) Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid) ( 24823311) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) PR interval ( 32439900) QT interval ( 30679814) Red blood cell fatty acid levels ( 25500335) Red cell distribution width ( 27863252 32888494) Refractive error ( 32231278) Response to statin therapy ( 20339536) Resting heart rate ( 20639392) Rheumatoid arthritis ( 24390342 30423114) Serum docosahexaenoic fatty acid concentration in metabolic syndrome ( 31991592) Serum metabolite concentrations in chronic kidney disease ( 29545352 33838163) Serum metabolite levels ( 23093944 31636271 33031748) Serum metabolite levels (CMS) ( 31636271) Serum metabolite ratios in chronic kidney disease ( 29545352) Serum omega-3 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Sphingolipid levels ( 22359512) Stearic acid (18:0) levels ( 23362303) Sum eosinophil basophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Total cholesterol levels ( 28334899 29615537) Triacylglycerol 56:6 levels ( 31560688) Triglyceride levels ( 28334899 29403010 33339817) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 19060906 20686565 20864672 24097068 25961943) Vaccenic acid (18:1n-7) levels ( 28298293) Vitamin C levels ( 33203707) White blood cell count ( 27863252 32888494) Youthful appearance (self-reported) ( 32339537)
Novel Interacting Genes		2 novel interacting genes: EEF1G POLR2E
Interacting Genes		1 interacting genes: XRN1
Entrez ID		3992
HPRD ID		06935
Ensembl ID		ENSG00000149485
Uniprot IDs		A0A0A0MR51 O60427
PDB IDs
Enriched GO Terms of Interacting Partners?		Cellular Response To Puromycin Cellular Response To Cycloheximide TRNA Transcription By RNA Polymerase III RPAP3/R2TP/prefoldin-like Complex Transcription Elongation By RNA Polymerase I 5'-3' Exonuclease Activity Response To Cycloheximide G-quadruplex RNA Binding 5'-3' RNA Exonuclease Activity Nuclear MRNA Surveillance G-quadruplex DNA Binding TRNA Transcription RNA Polymerase I Complex RNA Polymerase III Complex RNA Polymerase II, Core Complex RRNA Catabolic Process Histone MRNA Catabolic Process Translation Elongation Factor Activity Telomerase RNA Binding Negative Regulation Of Telomere Maintenance Via Telomerase Histone MRNA Metabolic Process DNA-directed RNA Polymerase Activity Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Transcription By RNA Polymerase III DNA-directed RNA Polymerase Complex Nuclear RNA Surveillance Negative Regulation Of Telomere Maintenance RNA Surveillance Response To Testosterone Regulation Of Telomere Maintenance Via Telomerase Exonuclease Activity DNA-templated Transcription Elongation Regulation Of Telomere Maintenance Via Telomere Lengthening Translational Elongation
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