CTF1 and TLX1

Number of citations of the paper that reports this interaction (PubMedID 16357834)
0

Data Source:
BioGRID (pull down)

		CTF1	TLX1
Description		cardiotrophin 1	T cell leukemia homeobox 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Chromatin Nucleus
	Molecular Function	Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell-cell Signaling Nervous System Development Muscle Organ Development Positive Regulation Of Cell Population Proliferation Neuron Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Neuron Development	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Animal Organ Development
Pathways		IL-6-type cytokine receptor ligand interactions
Drugs
Diseases			Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
GWAS		Red blood cell count ( 27863252) Triglyceride levels ( 28334899) Triglycerides ( 20686565 24097068)	Mean spheric corpuscular volume ( 32888494) Refractive error ( 32231278) Regular attendance at a pub or social club ( 29970889)
Interacting Genes		9 interacting genes: APP EP300 IL6ST LIFR MAGEA6 S100A1 S100A6 S100P TLX1	11 interacting genes: CTF1 EIF4E MEIS1 MEIS2 NFIC PKNOX1 PPP1CB PPP1CC PPP2CA PPP2CB TLE1
Entrez ID		1489	3195
HPRD ID		02699	01728
Ensembl ID		ENSG00000150281	ENSG00000107807
Uniprot IDs		Q16619	P31314
PDB IDs
Enriched GO Terms of Interacting Partners?		Leukemia Inhibitory Factor Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M Receptor Activity Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Calcium-dependent Protein Binding T-helper 17 Cell Lineage Commitment S100 Protein Binding T-helper Cell Lineage Commitment Transition Metal Ion Binding CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Receptor Complex T Cell Lineage Commitment Extracellular Region Cytokine Binding Growth Factor Binding Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Myeloid Cell Development Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Homodimerization Activity Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Histone Crotonyltransferase Activity Cytokine Receptor Activity External Side Of Plasma Membrane Regulation Of ATP Metabolic Process Acetylcholine Receptor Activator Activity Positive Regulation Of Cell Activation Cell Body Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Purine Nucleotide Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Identical Protein Binding	Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Phosphoprotein Phosphatase Activity Dephosphorylation Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process PTW/PP1 Phosphatase Complex Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Protein Phosphatase Type 2A Complex FAR/SIN/STRIPAK Complex Eye Development Response To Lead Ion Entrainment Of Circadian Clock By Photoperiod Photoperiodism Entrainment Of Circadian Clock Chromosome, Centromeric Region Sensory Organ Development Animal Organ Morphogenesis Chromatin Nucleus Tau Protein Binding Transcription Regulator Complex Developmental Process Eukaryotic Initiation Factor 4G Binding Negative Regulation Of Cell Differentiation Embryonic Pattern Specification Glycogen Metabolic Process Myosin-light-chain-phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S7 Phosphatase Activity RNA Polymerase II CTD Heptapeptide Repeat S2 Phosphatase Activity Transcription By RNA Polymerase II Regulation Of Microtubule Polymerization Circadian Regulation Of Gene Expression Negative Regulation Of Neuron Differentiation Response To Light Stimulus Energy Reserve Metabolic Process Polysaccharide Metabolic Process Phosphatase Activity Leukemia Inhibitory Factor Receptor Binding RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Neuron Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Cell Population Proliferation Regulation Of Translation At Postsynapse, Modulating Synaptic Transmission Regulation Of Cell Differentiation Positive Regulation Of Cardiac Muscle Myoblast Proliferation Regulation Of Microtubule Polymerization Or Depolymerization Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Developmental Process
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