CTF1 and IL6ST

Number of citations of the paper that reports this interaction (PMID 11834704)
8

Data Source:
HPRD (in vivo)

		CTF1	IL6ST
Gene Name		cardiotrophin 1	interleukin 6 signal transducer
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex Oncostatin-M Receptor Complex External Side Of Plasma Membrane Membrane Dendrite Neuronal Cell Body Extracellular Vesicular Exosome Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Cytokine Activity Leukemia Inhibitory Factor Receptor Binding	Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Interleukin-6 Receptor Binding Protein Binding Growth Factor Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Interleukin-27 Receptor Activity
	Biological Process	Cell-cell Signaling Nervous System Development Muscle Organ Development Cell Proliferation Positive Regulation Of Cell Proliferation Neuron Development Leukemia Inhibitory Factor Signaling Pathway	Positive Regulation Of Acute Inflammatory Response Positive Regulation Of Adaptive Immune Response Glycogen Metabolic Process Positive Regulation Of Cell Proliferation Regulation Of Notch Signaling Pathway Positive Regulation Vascular Endothelial Growth Factor Production Positive Regulation Of Cardiac Muscle Hypertrophy Viral Process Cytokine-mediated Signaling Pathway Response To Cytokine Interleukin-11-mediated Signaling Pathway Oncostatin-M-mediated Signaling Pathway Positive Regulation Of T Cell Proliferation Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Apoptotic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Astrocyte Differentiation Leukemia Inhibitory Factor Signaling Pathway Interleukin-6-mediated Signaling Pathway Negative Regulation Of Interleukin-6-mediated Signaling Pathway Interleukin-27-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways			Signaling by Interleukins Interleukin-6 signaling Cytokine Signaling in Immune system
Drugs
Diseases
GWAS		Triglycerides ( 20686565)	Crohn's disease ( 23128233) IgG glycosylation ( 23382691) Rheumatoid arthritis ( 20453842)
Protein-Protein Interactions		5 interactors: APP EP300 IL6ST LIFR MAGEA6	31 interactors: AR CDK9 CNTF CNTFR CTF1 ERBB2 ERBB3 HCK IL31RA IL6 IL6R JAK1 KCNIP3 LIF LIFR MAGEA11 OSM OSMR PIK3CG PLAUR PRKCD PTPN11 PTPN6 SGTB SHC1 SOCS3 STAT3 TLE1 TYK2 UBQLN1 VAV1
Entrez ID		1489	3572
HPRD ID		02699	02824
Ensembl ID		ENSG00000150281	ENSG00000134352
Uniprot IDs		Q16619	D6RH03 P40189 Q17RA0
PDB IDs			1BJ8 1BQU 1I1R 1N2Q 1P9M 1PVH 3L5H 3L5I 3L5J
Enriched GO Terms of Interacting Partners?		Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Histone H2B Acetylation Interleukin-11-mediated Signaling Pathway Notch Signaling Pathway Regulation Of Protein Binding Synaptic Growth At Neuromuscular Junction Interleukin-27-mediated Signaling Pathway Collateral Sprouting In Absence Of Injury N-terminal Peptidyl-lysine Acetylation Negative Regulation Of Interleukin-6-mediated Signaling Pathway Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Tubulin Deacetylation Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Cell Surface Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Neuron Remodeling Positive Regulation By Host Of Viral Transcription Positive Regulation Of Astrocyte Differentiation Positive Regulation Of Cytokine Production N-terminal Protein Amino Acid Acetylation Regulation Of Tyrosine Phosphorylation Of Stat1 Protein Regulation Of Cellular Amino Acid Metabolic Process Interleukin-6-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Posttranscriptional Regulation Of Gene Expression Positive Regulation Of Cardiac Muscle Hypertrophy Cellular Copper Ion Homeostasis Regulation Of Cellular Ketone Metabolic Process Cellular Response To Organic Substance Regulation Of Androgen Receptor Signaling Pathway Copper Ion Homeostasis Suckling Behavior Regulation Of Cytokine Production Regulation Of Cellular Protein Metabolic Process Viral Process Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Cellular Response To Interleukin-6 Cellular Response To Cytokine Stimulus N-terminal Protein Amino Acid Modification Positive Regulation Of Acute Inflammatory Response Regulation Of Astrocyte Differentiation	Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Cell Surface Receptor Signaling Pathway Response To Cytokine Cellular Response To Organic Substance Signal Transduction Enzyme Linked Receptor Protein Signaling Pathway Signaling Cellular Response To Stimulus Regulation Of Cell Proliferation Cell Communication Response To Organic Substance Positive Regulation Of Cell Proliferation Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Signal Transduction Response To Stimulus Immune Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Defense Response Regulation Of Signaling Peptidyl-tyrosine Phosphorylation Regulation Of Intracellular Signal Transduction Regulation Of Cell Death Response To Stress Regulation Of Immune System Process Regulation Of Phosphorylation Regulation Of Protein Phosphorylation Ciliary Neurotrophic Factor-mediated Signaling Pathway Regulation Of Apoptotic Process Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Phosphorus Metabolic Process Immune System Process Regulation Of Protein Metabolic Process JAK-STAT Cascade Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phosphorylation Regulation Of Immune Response Regulation Of Cellular Ketone Metabolic Process Leukocyte Migration Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Positive Regulation Of Protein Modification Process Positive Regulation Of Protein Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Peptidyl-tyrosine Phosphorylation Intracellular Signal Transduction Regulation Of JAK-STAT Cascade
Tagcloud ?		colonization ctf2 deltactf1 deltactf1deltactf2 deltactf2 existence fungal fungus fusarium gly inoculation lip1 lip2 lip22 lip3 lip5 lipase lipases lipolytic lycopersici mutants oxysporum pathogenicity pentapeptide severely silico thirteen tomato virulence	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		colonization ctf2 deltactf1 deltactf1deltactf2 deltactf2 existence fungal fungus fusarium gly inoculation lip1 lip2 lip22 lip3 lip5 lipase lipases lipolytic lycopersici mutants oxysporum pathogenicity pentapeptide severely silico thirteen tomato virulence	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il10ra il10rb il11ra il3ra lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?