CTF1 and LIFR

Number of citations: 97 (PubMedID 33961781)
Data Source: BioGRID (affinity chromatography technology), HPRD (in vivo)

		CTF1	LIFR
Name		cardiotrophin 1	LIF receptor subunit alpha
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Membrane Receptor Complex Extracellular Exosome
	Molecular Function	Cytokine Activity Leukemia Inhibitory Factor Receptor Binding Protein Binding	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Receptor Activity Oncostatin-M Receptor Activity Ciliary Neurotrophic Factor Receptor Binding Protein Binding Growth Factor Binding Cytokine Binding
	Biological Process	Cell Surface Receptor Signaling Pathway Via JAK-STAT Cell-cell Signaling Nervous System Development Muscle Organ Development Positive Regulation Of Cell Population Proliferation Neuron Differentiation Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Neuron Development	Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Response To Cytokine Oncostatin-M-mediated Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway
Pathways		IL-6-type cytokine receptor ligand interactions	IL-6-type cytokine receptor ligand interactions RUNX1 regulates transcription of genes involved in interleukin signaling
Diseases		None	Stuve-Wiedemann syndrome
GWAS		Red blood cell count ( 27863252 ) Triglyceride levels ( 28334899 ) Triglycerides ( 20686565 24097068 )	Blood protein levels ( 30072576 ) Crohn's disease ( 26192919 ) Inflammatory bowel disease ( 26192919 ) Pursuit maintenance gain ( 29064472 ) Ulcerative colitis ( 26192919 )
Interacting Genes		9 interacting genes: APP EP300 IL6ST LIFR MAGEA6 S100A1 S100A6 S100P TLX1	12 interacting genes: CNTF CNTFR CTF1 IL31RA IL6ST LIF MAPK1 OSM PLCG1 POU2F1 PTPN11 PTPN6
Entrez ID		1489	3977
HPRD ID		02699	01048
Ensembl ID		ENSG00000150281	ENSG00000113594
Uniprot IDs		Q16619	A8K1Z4 P42702
PDB IDs		Not available	3E0G 8D6A 8D74 8D7R 8V29 8V2A
GO Terms Enriched among Interactors		Leukemia Inhibitory Factor Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M Receptor Activity Oncostatin-M-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Ciliary Neurotrophic Factor Receptor Binding Calcium-dependent Protein Binding T-helper 17 Cell Lineage Commitment S100 Protein Binding T-helper Cell Lineage Commitment Transition Metal Ion Binding CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Receptor Complex T Cell Lineage Commitment Extracellular Region Cytokine Binding Growth Factor Binding Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Growth Cone Lamellipodium Myeloid Cell Development Regulation Of Response To Calcium Ion Regulation Of Carbohydrate Catabolic Process Regulation Of Glycolytic Process Amylin Binding Positive Regulation Of Toll Signaling Pathway Protein Homodimerization Activity Peptidyl-lysine Propionylation Swimming Histone Lactyltransferase (CoA-dependent) Activity Peptidyl-lysine Butyrylation Peptidyl-lysine Crotonylation Histone H3K122 Acetyltransferase Activity Histone Butyryltransferase Activity Cell Surface Receptor Signaling Pathway Via JAK-STAT Histone Crotonyltransferase Activity Cytokine Receptor Activity External Side Of Plasma Membrane Regulation Of ATP Metabolic Process Acetylcholine Receptor Activator Activity Positive Regulation Of Cell Activation Cell Body Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Purine Nucleotide Metabolic Process Lipoprotein Particle Positive Regulation Of Protein Import Identical Protein Binding	Positive Regulation Of Cell Population Proliferation Cytokine-mediated Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Regulation Of Peptidyl-tyrosine Phosphorylation Cell Surface Receptor Signaling Pathway Via STAT Regulation Of Tyrosine Phosphorylation Of STAT Protein Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Protein Phosphorylation Positive Regulation Of Phosphorylation Positive Regulation Of Phosphate Metabolic Process Positive Regulation Of Protein Modification Process Regulation Of Protein Phosphorylation Cell Surface Receptor Signaling Pathway Via JAK-STAT Regulation Of Phosphorylation Leukemia Inhibitory Factor Receptor Binding Cell Development Regulation Of Phosphorus Metabolic Process Ciliary Neurotrophic Factor Receptor Complex Positive Regulation Of Macromolecule Metabolic Process Signal Transduction Regulation Of Protein Modification Process Interleukin-11 Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-11 Binding Enzyme-linked Receptor Protein Signaling Pathway Leukemia Inhibitory Factor Signaling Pathway Oncostatin-M-mediated Signaling Pathway Cytokine Binding Phosphotyrosine Residue Binding Regulation Of Cell Adhesion Mediated By Integrin Positive Regulation Of Metabolic Process Cytokine Receptor Activity Regulation Of Inflammatory Response Response To Epidermal Growth Factor Ciliary Neurotrophic Factor Receptor Binding Positive Regulation Of Biosynthetic Process Positive Regulation Of Protein Metabolic Process Interleukin-6 Receptor Binding Interleukin-11-mediated Signaling Pathway Regulation Of Defense Response Negative Regulation Of Neutrophil Activation Epidermal Growth Factor Receptor Signaling Pathway Cytokine Activity Muscle Organ Morphogenesis Negative Regulation Of Hormone Secretion Regulation Of Multicellular Organismal Process ERBB Signaling Pathway