CLU and PLXNA4

Number of citations of the paper that reports this interaction (PubMedID 27378688)
23

Data Source:
BioGRID (pull down)

		CLU	PLXNA4
Description		clusterin	plexin A4
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Mitochondrial Inner Membrane Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Membrane Platelet Alpha Granule Lumen Cytoplasmic Vesicle Mitochondrial Membrane Protein-containing Complex Spherical High-density Lipoprotein Particle Chromaffin Granule Intracellular Membrane-bounded Organelle Synapse Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Blood Microparticle Neurofibrillary Tangle Apical Dendrite Perinuclear Endoplasmic Reticulum Lumen	Semaphorin Receptor Complex Plasma Membrane Membrane Cerebellar Climbing Fiber To Purkinje Cell Synapse
	Molecular Function	Amyloid-beta Binding Signaling Receptor Binding Protein Binding ATP Hydrolysis Activity Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein Heterodimerization Activity Receptor Ligand Activity Tau Protein Binding Low-density Lipoprotein Particle Receptor Binding Unfolded Protein Binding Protein-folding Chaperone Binding Misfolded Protein Binding Protein Sequestering Activity Protein Carrier Chaperone	Protein Binding Semaphorin Receptor Activity Signaling Receptor Activity
	Biological Process	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Negative Regulation Of Activation Of Membrane Attack Complex Immune System Process Immune Complex Clearance Protein Folding Lipid Metabolic Process Apoptotic Process Complement Activation Complement Activation, Classical Pathway Response To Virus Positive Regulation Of Gene Expression Protein Import Negative Regulation Of Protein-containing Complex Assembly Positive Regulation Of Protein-containing Complex Assembly Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Tumor Necrosis Factor Production Regulation Of Cell Population Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Complement Activation Positive Regulation Of Receptor-mediated Endocytosis Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Microglial Cell Proliferation Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Negative Regulation Of Release Of Cytochrome C From Mitochondria Intrinsic Apoptotic Signaling Pathway Amyloid-beta Clearance Regulation Of Amyloid-beta Clearance Positive Regulation Of Amyloid-beta Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Amyloid-beta Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Response To Endoplasmic Reticulum Stress Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Amyloid Fibril Formation Positive Regulation Of Amyloid Fibril Formation Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Cell Surface Receptor Signaling Pathway Nervous System Development Axon Guidance Synapse Assembly Motor Neuron Axon Guidance Telencephalon Development Cranial Nerve Morphogenesis Facial Nerve Morphogenesis Facial Nerve Structural Organization Glossopharyngeal Nerve Morphogenesis Trigeminal Nerve Morphogenesis Trigeminal Nerve Structural Organization Vagus Nerve Morphogenesis Postganglionic Parasympathetic Fiber Development Branchiomotor Neuron Axon Guidance Chemorepulsion Of Branchiomotor Axon Anterior Commissure Morphogenesis Regulation Of Cell Migration Embryonic Heart Tube Development Sympathetic Nervous System Development Neuron Projection Morphogenesis Regulation Of Axon Extension Involved In Axon Guidance Negative Chemotaxis Regulation Of Chemotaxis Regulation Of Negative Chemotaxis Semaphorin-plexin Signaling Pathway Sympathetic Neuron Axon Guidance Maintenance Of Synapse Structure
Pathways		Platelet degranulation Terminal pathway of complement Antimicrobial peptides Regulation of Complement cascade	Sema3A PAK dependent Axon repulsion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion CRMPs in Sema3A signaling CRMPs in Sema3A signaling Other semaphorin interactions FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Drugs		Zinc Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Alzheimer's disease ( 19734902 19734903 21627779 31473137) Alzheimer's disease (late onset) ( 21460841 24162737 30617256 28714976) Alzheimer's disease in APOE e4+ carriers ( 25778476) Alzheimer's disease in APOE e4- carriers ( 25778476) Alzheimer's disease or family history of Alzheimer's disease ( 33589840 30617256) Alzheimer's disease or fasting insulin levels (pleiotropy) ( 30805717) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Family history of Alzheimer's disease ( 30617256) Lung adenocarcinoma ( 28604730) Lung cancer in ever smokers ( 28604730) Panic disorder ( 19165232) Refractive error ( 32231278) Schizophrenia ( 29483656 25056061) Smoking behaviour (cigarettes smoked per day) ( 31089300) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Spherical equivalent or myopia (age of diagnosis) ( 29808027)	Age-related hearing impairment ( 24939585) Bipolar disorder ( 34002096 31043756) Bone mineral density (femoral neck) in inflammatory bowel disease ( 29603369) Chronotype ( 30696823) Cognitive function ( 24684796) Concussion ( 33017352) Diastolic blood pressure ( 27841878) Economic and political preferences ( 22566634) Femur bone mineral density x serum urate levels interaction ( 34046847) Fractures (paediatric) ( 32742401) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Oleic acid (18:1n-9) levels ( 23362303) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Refractive error ( 32231278) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Self-employment ( 23593239) Systolic blood pressure ( 27841878)
Interacting Genes		62 interacting genes: APP BAG6 BTG3 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 DLG4 DSCAM DSCR9 DYRK1A ELN EPPIN ETS2 FOS GRB2 HSPA13 HSPD1 HUNK IL24 KATNA1 KEAP1 KLF11 KNSTRN LCOR LEP LEPR LIG4 LRP1 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 MSRB1 PAXIP1 PLXNA4 POLR1C PON1 PRNP RBBP8 RPL23 RSPH1 SHANK3 SRPK2 SYVN1 TGFBR1 TGFBR2 TNIK TREM2 TSC22D4 TTR UBC VHL VLDLR XRCC6 ZWINT	1 interacting genes: CLU
Entrez ID		1191	91584
HPRD ID		01706	10901
Ensembl ID		ENSG00000120885	ENSG00000221866
Uniprot IDs		P10909	Q9HCM2
PDB IDs		7ZET 7ZEU	4E74
Enriched GO Terms of Interacting Partners?		Apolipoprotein Binding Low-density Lipoprotein Particle Receptor Activity Cell Projection Morphogenesis Neuron Projection Organization Neuron Projection Morphogenesis Positive Regulation Of Developmental Process Positive Regulation Of Cell Differentiation Receptor Complex Cell Activation Positive Regulation Of Protein Catabolic Process Membrane Attack Complex Other Organism Cell Membrane Regulation Of Proteolysis Cargo Receptor Activity Response To Stress Regulation Of Immune Response Regulation Of Cell Population Proliferation Positive Regulation Of Multicellular Organismal Process Signal Transduction Dendritic Spine Organization System Development Endocytosis Clathrin-coated Pit Memory Regulation Of Multicellular Organismal Process Positive Regulation Of Cell Development High-density Lipoprotein Particle Binding Anatomical Structure Morphogenesis Protein-containing Complex Binding Regulation Of Cell Projection Organization Intracellular Signal Transduction Complement Activation, GZMK Pathway Nervous System Development Cellular Response To Growth Factor Stimulus Reelin Receptor Activity Positive Regulation Of Proteolysis Transmembrane Transporter Complex Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Cell Surface Receptor Signaling Pathway Cell Projection Organization Positive Regulation Of Cell Activation Immune Effector Process Immune System Process Postsynapse Organization Regulation Of Immune System Process Regulation Of Developmental Process Complement Activation, Alternative Pathway Terpenoid Metabolic Process Cellular Response To Oxygen-containing Compound Cognition	Negative Regulation Of Activation Of Membrane Attack Complex Protein Targeting To Lysosome Involved In Chaperone-mediated Autophagy Perinuclear Endoplasmic Reticulum Lumen Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Inclusion Body Assembly Negative Regulation Of Complement-dependent Cytotoxicity Central Nervous System Myelin Maintenance Neurofibrillary Tangle Chromaffin Granule Regulation Of Neuronal Signal Transduction Positive Regulation Of Amyloid Fibril Formation Immune Complex Clearance Regulation Of Neurofibrillary Tangle Assembly Protein Import Spherical High-density Lipoprotein Particle Microglial Cell Proliferation Protein Carrier Chaperone Apical Dendrite Negative Regulation Of Amyloid Fibril Formation Myelin Maintenance Negative Regulation Of Release Of Cytochrome C From Mitochondria Protein Targeting To Vacuole Involved In Autophagy Regulation Of Complement-dependent Cytotoxicity Regulation Of Amyloid Fibril Formation Negative Regulation Of Complement Activation Response To Misfolded Protein Reverse Cholesterol Transport Misfolded Protein Binding Positive Regulation Of Amyloid-beta Formation Regulation Of Amyloid-beta Clearance Regulation Of Inclusion Body Assembly Chaperone-mediated Protein Complex Assembly Regulation Of Complement Activation Release Of Cytochrome C From Mitochondria Low-density Lipoprotein Particle Receptor Binding Positive Regulation Of Amyloid Precursor Protein Catabolic Process Negative Regulation Of Amyloid-beta Formation Amyloid-beta Clearance Negative Regulation Of Amyloid Precursor Protein Catabolic Process Glial Cell Proliferation Microglial Cell Activation Protein Targeting To Lysosome Positive Regulation Of Amide Metabolic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Leukocyte Activation Involved In Inflammatory Response Complement Activation, Classical Pathway Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Release Of Cytochrome C From Mitochondria Regulation Of Amyloid-beta Formation
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