CLU and CYP2E1

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		CLU	CYP2E1
Gene Name		clusterin	cytochrome P450, family 2, subfamily E, polypeptide 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Matrix Platelet Alpha Granule Lumen Mitochondrial Membrane Spherical High-density Lipoprotein Particle Chromaffin Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle Neurofibrillary Tangle Apical Dendrite	Golgi Membrane Cytoplasm Mitochondrion Endoplasmic Reticulum Membrane Intrinsic Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Misfolded Protein Binding	Monooxygenase Activity Iron Ion Binding Arachidonic Acid Epoxygenase Activity Steroid Hydroxylase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, Reduced Flavin Or Flavoprotein As One Donor, And Incorporation Of One Atom Of Oxygen Oxygen Binding Enzyme Binding Heme Binding
	Biological Process	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Blood Coagulation Response To Virus Protein Import Platelet Activation Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Chaperone-mediated Protein Folding Microglial Cell Proliferation Intrinsic Apoptotic Signaling Pathway Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Beta-amyloid Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Triglyceride Metabolic Process Xenobiotic Metabolic Process Steroid Metabolic Process Response To Ozone Response To Organonitrogen Compound Monoterpenoid Metabolic Process Drug Metabolic Process Epoxygenase P450 Pathway Exogenous Drug Catabolic Process Small Molecule Metabolic Process Response To Ethanol Heterocycle Metabolic Process Oxidation-reduction Process
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Defective CYP2R1 causes Rickets vitamin D-dependent 1B (VDDR1B) Metabolic disorders of biological oxidation enzymes Phase 1 - Functionalization of compounds Defective CYP27B1 causes Rickets vitamin D-dependent 1A (VDDR1A) Defective CYP26C1 causes Focal facial dermal dysplasia 4 (FFDD4) Defective CYP2U1 causes Spastic paraplegia 56, autosomal recessive (SPG56) Cytochrome P450 - arranged by substrate type CYP2E1 reactions Biological oxidations Defective TBXAS1 causes Ghosal hematodiaphyseal dysplasia (GHDD) Defective FMO3 causes Trimethylaminuria (TMAU) Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) Defective CYP27A1 causes Cerebrotendinous xanthomatosis (CTX) Defective CYP11B1 causes Adrenal hyperplasia 4 (AH4) Defective CYP26B1 causes Radiohumeral fusions with other skeletal and craniofacial anomalies (RHFCA) Defective CYP1B1 causes Glaucoma Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5) Defective CYP7B1 causes Spastic paraplegia 5A, autosomal recessive (SPG5A) and Congenital bile acid synthesis defect 3 (CBAS3) Defective CYP19A1 causes Aromatase excess syndrome (AEXS) Defective CYP4F22 causes Ichthyosis, congenital, autosomal recessive 5 (ARCI5) Defective CYP24A1 causes Hypercalcemia, infantile (HCAI) Xenobiotics Defective MAOA causes Brunner syndrome (BRUNS) Defective CYP11B2 causes Corticosterone methyloxidase 1 deficiency (CMO-1 deficiency) Defective CYP21A2 causes Adrenal hyperplasia 3 (AH3)
Drugs
Diseases
GWAS		Alzheimer's disease ( 19734902 19734903 21627779) Alzheimer's disease (late onset) ( 21460841) Panic disorder ( 19165232)	Obesity-related traits ( 23251661) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738)
Protein-Protein Interactions		44 interactors: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 PAXIP1 POLR1C PON1 PRNP RBBP8 RPL23 SYVN1 TGFBR1 TGFBR2 TNIK TSC22D4 TTR VHL VLDLR XRCC6 ZWINT	15 interactors: ABCA5 AGXT2 AMFR CLU CYB5A ECHS1 FANCG GATM LAMC3 MAFG NMI POR PTN RPL13A STUB1
Entrez ID		1191	1571
HPRD ID		01706	11813
Ensembl ID		ENSG00000120885	ENSG00000130649
Uniprot IDs		P10909	P05181
PDB IDs			3E4E 3E6I 3GPH 3KOH 3LC4 3T3Z
Enriched GO Terms of Interacting Partners?		Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Developmental Process Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Cell Differentiation Defense Response Multicellular Organismal Development Cytolysis Cellular Response To Stimulus Innate Immune Response Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Central Nervous System Development Positive Regulation Of Proteolysis Complement Activation, Alternative Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Cell Development Response To External Stimulus Positive Regulation Of Cell Differentiation Regulation Of Phosphorylation Generation Of Neurons Alcohol Metabolic Process Positive Regulation Of Metabolic Process System Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Phosphorylation Neurogenesis Steroid Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation	Response To Misfolded Protein Reverse Cholesterol Transport Regulation Of Hormone Metabolic Process Carboxylic Acid Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Stress Catabolic Process Organic Acid Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Cellular Organofluorine Metabolic Process L-alanine Catabolic Process, By Transamination Negative Regulation Of Formation Of Translation Preinitiation Complex Nitrate Catabolic Process Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Nitric Oxide Catabolic Process Regulation Of Neuronal Signal Transduction Sterol Transport Cholesterol Transport Regulation Of Reactive Oxygen Species Biosynthetic Process Fatty Acid Oxidation Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Lipid Oxidation Positive Regulation Of Proteasomal Protein Catabolic Process Creatine Biosynthetic Process Positive Regulation Of Chaperone-mediated Protein Complex Assembly Regulation Of Growth Plate Cartilage Chondrocyte Proliferation Positive Regulation Of Neurofibrillary Tangle Assembly Glycine Biosynthetic Process, By Transamination Of Glyoxylate Positive Regulation Of Reactive Oxygen Species Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Regulation Of Steroid Metabolic Process Cellular Response To Unfolded Protein Glyoxylate Catabolic Process Nitrate Metabolic Process Glial Cell Development ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Stimulus L-alanine Metabolic Process L-alanine Catabolic Process Central Nervous System Myelin Maintenance Single-organism Behavior Response To Organic Substance Regulation Of Tau-protein Kinase Activity Response To Unfolded Protein Cellular Amino Acid Biosynthetic Process Positive Regulation Of Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tagcloud ?		allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss	afforded gsh hexane hexanedione hydroxyl knock metabolizes mptp name neurotoxic nigra nigral nitric nitroindazole nonspecific nos p450 parkinson parkinsonism peroxidation postmortem presumably primates radicals striatum substantia toxins unidentified
Tagcloud (Difference) ?		allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss	afforded gsh hexane hexanedione hydroxyl knock metabolizes mptp name neurotoxic nigra nigral nitric nitroindazole nonspecific nos p450 parkinson parkinsonism peroxidation postmortem presumably primates radicals striatum substantia toxins unidentified
Tagcloud (Intersection) ?