CLU and CLUAP1

Number of citations of the paper that reports this interaction (PMID 15480429)
4

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vivo)

		CLU	CLUAP1
Gene Name		clusterin	clusterin associated protein 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Matrix Platelet Alpha Granule Lumen Mitochondrial Membrane Spherical High-density Lipoprotein Particle Chromaffin Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle Neurofibrillary Tangle Apical Dendrite	Nucleoplasm Centrosome Cilium Intraciliary Transport Particle B Intracellular Membrane-bounded Organelle Primary Cilium Ciliary Tip
	Molecular Function	Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Misfolded Protein Binding	Protein Binding
	Biological Process	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Blood Coagulation Response To Virus Protein Import Platelet Activation Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Chaperone-mediated Protein Folding Microglial Cell Proliferation Intrinsic Apoptotic Signaling Pathway Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Beta-amyloid Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Organelle Organization Cilium Assembly
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation	Organelle biogenesis and maintenance Assembly of the primary cilium Intraflagellar transport
Drugs
Diseases
GWAS		Alzheimer's disease ( 19734902 19734903 21627779) Alzheimer's disease (late onset) ( 21460841) Panic disorder ( 19165232)
Protein-Protein Interactions		44 interactors: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 PAXIP1 POLR1C PON1 PRNP RBBP8 RPL23 SYVN1 TGFBR1 TGFBR2 TNIK TSC22D4 TTR VHL VLDLR XRCC6 ZWINT	5 interactors: APP CINP CLU MAGEA11 MYOG
Entrez ID		1191	23059
HPRD ID		01706	10013
Ensembl ID		ENSG00000120885	ENSG00000103351
Uniprot IDs		P10909	J3KNW5 Q96AJ1
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Developmental Process Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Cell Differentiation Defense Response Multicellular Organismal Development Cytolysis Cellular Response To Stimulus Innate Immune Response Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Central Nervous System Development Positive Regulation Of Proteolysis Complement Activation, Alternative Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Cell Development Response To External Stimulus Positive Regulation Of Cell Differentiation Regulation Of Phosphorylation Generation Of Neurons Alcohol Metabolic Process Positive Regulation Of Metabolic Process System Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Phosphorylation Neurogenesis Steroid Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation	Platelet Degranulation Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Muscle Atrophy Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Response To Muscle Activity Involved In Regulation Of Muscle Adaptation Synaptic Growth At Neuromuscular Junction Positive Regulation Of Neurofibrillary Tangle Assembly Platelet Activation Collateral Sprouting In Absence Of Injury Positive Regulation Of Cell Cycle Process Central Nervous System Myelin Maintenance Response To Electrical Stimulus Involved In Regulation Of Muscle Adaptation Collateral Sprouting Axon Midline Choice Point Recognition Regulation Of Tau-protein Kinase Activity Positive Regulation Of Cell Cycle Positive Regulation Of Proteolysis Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Protein Homooligomerization Positive Regulation Of Inclusion Body Assembly Axon Choice Point Recognition Positive Regulation Of Skeletal Muscle Fiber Development Regulation Of Beta-amyloid Clearance Striated Muscle Atrophy Positive Regulation Of Cellular Biosynthetic Process Exocytosis Muscle Atrophy Regulation Of Satellite Cell Proliferation Positive Regulation Of Beta-amyloid Formation Neuron Remodeling Negative Regulation Of Protein Oligomerization Response To Denervation Involved In Regulation Of Muscle Adaptation Negative Regulation Of Beta-amyloid Formation Cell Development Blood Coagulation Hemostasis Response To Inactivity MRNA Transcription From RNA Polymerase II Promoter Posttranscriptional Regulation Of Gene Expression Response To Muscle Activity Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Negative Regulation Of Amyloid Precursor Protein Catabolic Process Regulation Of Cell Cycle Process Glial Cell Proliferation MRNA Transcription Response To Misfolded Protein Secretion By Cell Regulation Of Beta-amyloid Formation
Tagcloud ?		allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss	analyzing anatomical begin cilia ciliogenesis cystic defects die elegans embryos enlarged evolutionarily galactosidase gross hedgehog homologs immunofluorescence implicate indicative intraflagellar localizes pericardial phenotypes qrt repressed sac sonic turning utilizing
Tagcloud (Difference) ?		allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss	analyzing anatomical begin cilia ciliogenesis cystic defects die elegans embryos enlarged evolutionarily galactosidase gross hedgehog homologs immunofluorescence implicate indicative intraflagellar localizes pericardial phenotypes qrt repressed sac sonic turning utilizing
Tagcloud (Intersection) ?