CLU and PON1

Number of citations of the paper that reports this interaction (PMID 8292612)
19

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, in vivo)

		CLU	PON1
Gene Name		clusterin	paraoxonase 1
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Matrix Platelet Alpha Granule Lumen Mitochondrial Membrane Spherical High-density Lipoprotein Particle Chromaffin Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle Neurofibrillary Tangle Apical Dendrite	Extracellular Region Extracellular Space High-density Lipoprotein Particle Spherical High-density Lipoprotein Particle Intracellular Membrane-bounded Organelle Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Misfolded Protein Binding	Aryldialkylphosphatase Activity Arylesterase Activity Calcium Ion Binding Phospholipid Binding Protein Homodimerization Activity
	Biological Process	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Blood Coagulation Response To Virus Protein Import Platelet Activation Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Chaperone-mediated Protein Folding Microglial Cell Proliferation Intrinsic Apoptotic Signaling Pathway Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Beta-amyloid Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Response To External Stimulus Response To Toxic Substance Positive Regulation Of Cholesterol Efflux Dephosphorylation Aromatic Compound Catabolic Process Response To Nutrient Levels Positive Regulation Of Transporter Activity Negative Regulation Of Plasma Lipoprotein Particle Oxidation Carboxylic Acid Catabolic Process Organophosphate Catabolic Process Phosphatidylcholine Metabolic Process Positive Regulation Of Binding Response To Fatty Acid Response To Fluoride
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs			Cefazolin
Diseases
GWAS		Alzheimer's disease ( 19734902 19734903 21627779) Alzheimer's disease (late onset) ( 21460841) Panic disorder ( 19165232)	Metabolite levels ( 23281178) Response to TNF antagonist treatment ( 18615156)
Protein-Protein Interactions		44 interactors: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 PAXIP1 POLR1C PON1 PRNP RBBP8 RPL23 SYVN1 TGFBR1 TGFBR2 TNIK TSC22D4 TTR VHL VLDLR XRCC6 ZWINT	3 interactors: ALB APOA1 CLU
Entrez ID		1191	5444
HPRD ID		01706	01351
Ensembl ID		ENSG00000120885
Uniprot IDs		P10909	P27169
PDB IDs			1V04 1XHR
Enriched GO Terms of Interacting Partners?		Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Developmental Process Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Cell Differentiation Defense Response Multicellular Organismal Development Cytolysis Cellular Response To Stimulus Innate Immune Response Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Central Nervous System Development Positive Regulation Of Proteolysis Complement Activation, Alternative Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Cell Development Response To External Stimulus Positive Regulation Of Cell Differentiation Regulation Of Phosphorylation Generation Of Neurons Alcohol Metabolic Process Positive Regulation Of Metabolic Process System Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Phosphorylation Neurogenesis Steroid Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation	Platelet Degranulation Platelet Activation Reverse Cholesterol Transport Lipid Transport Lipid Localization Exocytosis Blood Coagulation Hemostasis Secretion By Cell Regulation Of Body Fluid Levels Wound Healing Secretion Sterol Transport Cholesterol Transport Cell Activation Response To Wounding Protein Stabilization Regulation Of Protein Stability Negative Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Lipoprotein Metabolic Process Lipid Metabolic Process Vesicle-mediated Transport Maintenance Of Mitochondrion Location Positive Regulation Of Neurofibrillary Tangle Assembly Negative Regulation Of Interleukin-1 Beta Secretion Response To Nutrient Steroid Metabolic Process Negative Regulation Of Very-low-density Lipoprotein Particle Remodeling Cholesterol Import Response To Platinum Ion Hemolysis By Symbiont Of Host Erythrocytes Positive Regulation Of Circadian Sleep/wake Cycle, Non-REM Sleep Central Nervous System Myelin Maintenance Negative Regulation Of Interleukin-1 Secretion Response To External Stimulus Positive Regulation Of Cellular Component Biogenesis Cellular Component Assembly Regulation Of Tau-protein Kinase Activity Establishment Of Localization In Cell Receptor-mediated Endocytosis Negative Regulation Of Protein Homooligomerization High-density Lipoprotein Particle Clearance Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Protein Oxidation Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of Cytokine Secretion Involved In Immune Response
Tagcloud ?		allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss	admission apoa1 atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase reside risen subfraction subgroups thrombolytic variation
Tagcloud (Difference) ?		allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss	admission apoa1 atherosclerosis believed concentration consequence controls explain explanation explicable fifth genotypes hdl immediately infarction mi microg min ml myocardial nmol occured paraoxonase reside risen subfraction subgroups thrombolytic variation
Tagcloud (Intersection) ?