CLU and IL24

Number of citations of the paper that reports this interaction (PMID 21732348)
2

Data Source:
BioGRID (pull down, pull down)

		CLU	IL24
Gene Name		clusterin	interleukin 24
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Mitochondrion Endoplasmic Reticulum Cytosol Extracellular Matrix Platelet Alpha Granule Lumen Mitochondrial Membrane Spherical High-density Lipoprotein Particle Chromaffin Granule Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle Neurofibrillary Tangle Apical Dendrite	Extracellular Space Endoplasmic Reticulum
	Molecular Function	Protein Binding ATPase Activity Ubiquitin Protein Ligase Binding Misfolded Protein Binding	Cytokine Activity
	Biological Process	Cell Morphogenesis Microglial Cell Activation Release Of Cytochrome C From Mitochondria Platelet Degranulation Lipid Metabolic Process Complement Activation Complement Activation, Classical Pathway Blood Coagulation Response To Virus Protein Import Platelet Activation Central Nervous System Myelin Maintenance Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Protein Homooligomerization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Apoptotic Process Reverse Cholesterol Transport Innate Immune Response Positive Regulation Of Nitric Oxide Biosynthetic Process Protein Stabilization Positive Regulation Of NF-kappaB Transcription Factor Activity Chaperone-mediated Protein Complex Assembly Response To Misfolded Protein Chaperone-mediated Protein Folding Microglial Cell Proliferation Intrinsic Apoptotic Signaling Pathway Regulation Of Beta-amyloid Clearance Regulation Of Neuron Death Positive Regulation Of Neuron Death Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Beta-amyloid Formation Regulation Of Neuronal Signal Transduction Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Neurofibrillary Tangle Assembly Positive Regulation Of Protein Ubiquitination Involved In Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Apoptotic Process Inflammatory Response Immune Response Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Migration Serine Phosphorylation Of STAT3 Protein Wound Healing Positive Regulation Of Tyrosine Phosphorylation Of Stat3 Protein Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of JAK-STAT Cascade Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-4
Pathways		Response to elevated platelet cytosolic Ca2+ Platelet degranulation Platelet activation, signaling and aggregation
Drugs
Diseases
GWAS		Alzheimer's disease ( 19734902 19734903 21627779) Alzheimer's disease (late onset) ( 21460841) Panic disorder ( 19165232)	Inflammatory bowel disease ( 23128233)
Protein-Protein Interactions		44 interactors: APP BAG6 C7 C8B C9 CBY1 CD209 CLUAP1 CYP2E1 DISC1 ELN FOS GRB2 HSPD1 IL24 KATNA1 KEAP1 KLF11 KNSTRN LEP LEPR LIG4 LRP2 LRP8 LYZ MAPK9 MDM2 MMP25 PAXIP1 POLR1C PON1 PRNP RBBP8 RPL23 SYVN1 TGFBR1 TGFBR2 TNIK TSC22D4 TTR VHL VLDLR XRCC6 ZWINT	5 interactors: CCR5 CLU DCD IL20RA RARG
Entrez ID		1191	11009
HPRD ID		01706	04995
Ensembl ID		ENSG00000120885	ENSG00000162892
Uniprot IDs		P10909	Q13007
PDB IDs
Enriched GO Terms of Interacting Partners?		Response To Stress Response To Stimulus Regulation Of Protein Metabolic Process Response To Radiation Response To Abiotic Stimulus Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Anatomical Structure Development Developmental Process Immune System Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Cellular Metabolic Process Immune Response Regulation Of Immune System Process Regulation Of Cell Differentiation Defense Response Multicellular Organismal Development Cytolysis Cellular Response To Stimulus Innate Immune Response Nervous System Development Regulation Of Metabolic Process Positive Regulation Of Protein Modification Process Central Nervous System Development Positive Regulation Of Proteolysis Complement Activation, Alternative Pathway Negative Regulation Of Cellular Metabolic Process Regulation Of Protein Phosphorylation Response To Light Stimulus Regulation Of Cell Development Response To External Stimulus Positive Regulation Of Cell Differentiation Regulation Of Phosphorylation Generation Of Neurons Alcohol Metabolic Process Positive Regulation Of Metabolic Process System Development Positive Regulation Of Immune System Process Negative Regulation Of Apoptotic Process Response To Organic Substance Negative Regulation Of Programmed Cell Death Positive Regulation Of Protein Phosphorylation Neurogenesis Steroid Metabolic Process Regulation Of Apoptotic Process Apoptotic Process Regulation Of Protein Processing Negative Regulation Of Cell Death Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation	Positive Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Positive Regulation Of Tau-protein Kinase Activity Microglial Cell Proliferation Regulation Of Neuronal Signal Transduction Response To Other Organism Response To Biotic Stimulus Growth Plate Cartilage Chondrocyte Growth Positive Regulation Of Neurofibrillary Tangle Assembly Regulation Of Intrinsic Apoptotic Signaling Pathway Growth Plate Cartilage Chondrocyte Development Harderian Gland Development Response To Organic Substance Positive Regulation Of Apoptotic Signaling Pathway Central Nervous System Myelin Maintenance Chondrocyte Hypertrophy Growth Plate Cartilage Chondrocyte Differentiation Regulation Of Tau-protein Kinase Activity Negative Regulation Of Protein Homooligomerization Positive Regulation Of Inclusion Body Assembly Regulation Of Beta-amyloid Clearance Retinal Pigment Epithelium Development Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Defense Response Lacrimal Gland Development Positive Regulation Of Beta-amyloid Formation Negative Regulation Of Protein Oligomerization Negative Regulation Of Beta-amyloid Formation Regulation Of Apoptotic Process Sarcoplasmic Reticulum Calcium Ion Transport Chondrocyte Development Involved In Endochondral Bone Morphogenesis Regulation Of Cell Death Trachea Cartilage Development Chaperone-mediated Protein Complex Assembly Microglial Cell Activation Dendritic Cell Chemotaxis Negative Regulation Of Amyloid Precursor Protein Catabolic Process Cellular Response To Lipid Glial Cell Proliferation Response To Misfolded Protein Cytokine-mediated Signaling Pathway Chondrocyte Differentiation Involved In Endochondral Bone Morphogenesis Regulation Of Beta-amyloid Formation Growth Plate Cartilage Development Regulation Of Inclusion Body Assembly Reverse Cholesterol Transport Regulation Of Amyloid Precursor Protein Catabolic Process Response To Bacterium
Tagcloud ?		allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss	10b 10c 10d 11b 19l colonystimulating cxcl13 cxcl14 cxcl2 ifnalpha14 ifnalpha5 ifnalpha6 ifnalpha8 ifnepsilon1 ifnkappa ifnomega1 il13 il17beta il19 il1alpha il22 il23alpha il25 il28a il3 il31 il9 imbalanced pe
Tagcloud (Difference) ?		allometric allometry amphotericin bolus cmin contributions cpeak disposition hplc humans insignificant inspite interspecies mrt parameter perform pharmacokinetic pharmacokinetics predictions preliminary rabbits rationalized scaling t0 triexponential vdarea vss vuss	10b 10c 10d 11b 19l colonystimulating cxcl13 cxcl14 cxcl2 ifnalpha14 ifnalpha5 ifnalpha6 ifnalpha8 ifnepsilon1 ifnkappa ifnomega1 il13 il17beta il19 il1alpha il22 il23alpha il25 il28a il3 il31 il9 imbalanced pe
Tagcloud (Intersection) ?