LDLRAP1 and ESPNL

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		LDLRAP1	ESPNL
Description		low density lipoprotein receptor adaptor protein 1	espin like
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Recycling Endosome	Cytoplasm Stereocilium Stereocilium Tip Cell Projection
	Molecular Function	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport	Sensory Perception Of Sound Actin Filament Bundle Assembly
Pathways		Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance Transport of RCbl within the body	Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565 24097068 25961943) LDL cholesterol ( 20686565 24097068 25961943) LDL cholesterol levels ( 28334899) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Total cholesterol levels ( 28334899)
Interacting Genes		18 interacting genes: AP1B1 AP2B1 APP C6orf58 CLTC ESPNL FHL2 HOXC8 HOXD8 LDLR LRP2 MAGEA4 MAPK8IP3 NOTO PAX5 PSD4 SNCA TFAP2A	3 interacting genes: LDLRAP1 PFDN5 SERTAD2
Entrez ID		26119	339768
HPRD ID		05765	14170
Ensembl ID		ENSG00000157978	ENSG00000144488
Uniprot IDs		B3KR97 Q5SW96	B3KXY4 Q6ZVH7
PDB IDs		2G30
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Endolysosome Membrane Clathrin-coated Endocytic Vesicle Membrane Receptor-mediated Endocytosis Negative Regulation Of Transcription By RNA Polymerase II Amyloid-beta Clearance Endocytosis Skeletal System Morphogenesis Vesicle-mediated Transport Positive Regulation Of Lysosomal Protein Catabolic Process Artery Development Clathrin Coat Kidney Development Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Import Into Cell Negative Regulation Of RNA Metabolic Process Pattern Specification Process Receptor Internalization Anatomical Structure Morphogenesis Regulation Of Lysosomal Protein Catabolic Process Clathrin Adaptor Complex Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Lysosome Low-density Lipoprotein Particle Low-density Lipoprotein Particle Receptor Activity Negative Regulation Of Metabolic Process Regulation Of Amyloid Fibril Formation Regionalization Transcytosis Negative Regulation Of Apoptotic Process Trans-Golgi Network Membrane Clathrin Coat Assembly Regulation Of Neurotransmitter Uptake Negative Regulation Of Programmed Cell Death Developmental Process Endosome Lumen Clathrin-coated Endocytic Vesicle Cellular Response To Copper Ion Regulation Of Receptor Recycling Coronary Vasculature Development Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Synaptic Vesicle	RNA Polymerase III Assembly RNA Polymerase I Assembly RNA Polymerase II Core Complex Assembly Amyloid-beta Binding Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Intracellular Cholesterol Transport Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Intracellular Lipid Transport AP-1 Adaptor Complex Binding Prefoldin Complex Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Lipid Transport AP-2 Adaptor Complex Binding Neurofilament Negative Regulation Of Amyloid Fibril Formation Low-density Lipoprotein Particle Clearance Regulation Of Cellular Component Organization Regulation Of Amyloid Fibril Formation Clathrin Adaptor Activity Regulation Of Low-density Lipoprotein Particle Clearance Amyloid Precursor Protein Metabolic Process Low-density Lipoprotein Particle Receptor Binding Plasma Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Metabolic Process Signaling Receptor Complex Adaptor Activity Clathrin Binding Positive Regulation Of Cholesterol Transport Regulation Of Protein Binding Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Steroid Metabolic Process Intermediate Filament Cytoskeleton Phosphotyrosine Residue Binding Regulation Of Cholesterol Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?