LDLRAP1 and AP2B1

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (pull down)
HPRD (two hybrid)

		LDLRAP1	AP2B1
Gene Name		low density lipoprotein receptor adaptor protein 1	adaptor-related protein complex 2, beta 1 subunit
Image
Gene Ontology Annotations	Cellular Component	Early Endosome Cytosol Neurofilament Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane AP-1 Adaptor Complex AP-2 Adaptor Complex Axon Recycling Endosome	Cytosol Plasma Membrane Membrane AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Beta-amyloid Binding Phosphotyrosine Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Receptor Signaling Complex Scaffold Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity Low-density Lipoprotein Particle Receptor Binding	Signal Sequence Binding Protein Binding Protein Transporter Activity Clathrin Binding Clathrin Adaptor Activity
	Biological Process	Transport Receptor-mediated Endocytosis Cholesterol Metabolic Process Positive Regulation Of Signal Transduction Receptor Internalization Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Regulation Of Establishment Of Protein Localization To Plasma Membrane Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process	Intracellular Protein Transport Epidermal Growth Factor Receptor Signaling Pathway Synaptic Transmission Axon Guidance Viral Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Ephrin Receptor Signaling Pathway Regulation Of Defense Response To Virus By Virus Clathrin-mediated Endocytosis
Pathways			Retrograde neurotrophin signalling Axon guidance HIV Infection Nef Mediated CD8 Down-regulation L1CAM interactions Signaling by Wnt Signaling by EGFRvIII in Cancer Recycling pathway of L1 EPH-ephrin mediated repulsion of cells MHC class II antigen presentation EPH-Ephrin signaling Nef Mediated CD4 Down-regulation EGFR downregulation Signalling by NGF Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters Host Interactions of HIV factors The role of Nef in HIV-1 replication and disease pathogenesis Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Signaling by Overexpressed Wild-Type EGFR in Cancer beta-catenin independent WNT signaling Signaling by EGFR WNT5A-dependent internalization of FZD4 Signaling by EGFR in Cancer PCP/CE pathway Adaptive Immune System
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565) LDL cholesterol ( 20686565)	Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		7 interactors: AP2B1 APP CLTC LDLR LRP2 OBFC1 TFAP2A	44 interactors: ACVR1 AFF4 AP1M1 AP1M2 AP2A2 AP2M1 AP2S1 APC ARRB1 ATM ATP6V1G1 BUB1 BUB1B CLINT1 CLTC DHX58 FAM46C GTF2I HIP1 ITSN1 KIAA0408 KPNA2 LDLRAP1 MEA1 MLH1 NECAP2 NEU4 NUP54 PIP5K1C POM121 RAPGEF3 RIBC2 SLC25A6 SMAD4 SMURF1 SNAP91 TERF2IP TGFBR1 TGFBR2 THAP1 TUBGCP4 TXN2 U2AF1 XRCC6BP1
Entrez ID		26119	163
HPRD ID		05765	03015
Ensembl ID		ENSG00000157978	ENSG00000006125
Uniprot IDs		B3KR97 Q5SW96	K7EJT8 P63010 Q96EL6
PDB IDs		2G30	1E42 2G30 2IV8 2IV9 2JKR 2JKT 2VGL 2XA7
Enriched GO Terms of Interacting Partners?		Endocytosis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Receptor-mediated Endocytosis Vesicle-mediated Transport Steroid Metabolic Process Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of ERBB Signaling Pathway Response To Light Stimulus Alcohol Metabolic Process Phototransduction, Visible Light Forebrain Development Response To Radiation Retinoid Metabolic Process Diterpenoid Metabolic Process Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Detection Of Visible Light Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Optic Cup Structural Organization Phototransduction Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Detection Of Light Stimulus Cholesterol Metabolic Process Isoprenoid Metabolic Process Optic Vesicle Morphogenesis Oculomotor Nerve Formation Synaptic Growth At Neuromuscular Junction Sterol Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Cholesterol Import Regulation Of Phosphatidylcholine Catabolic Process Collateral Sprouting In Absence Of Injury Positive Regulation Of Tooth Mineralization Negative Regulation Of Hyaluronan Biosynthetic Process Response To External Stimulus Brain Development Detection Of Abiotic Stimulus Oculomotor Nerve Development Head Development Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Antigen Processing And Presentation Of Peptide Antigen Neuron Development Central Nervous System Development Intestinal Cholesterol Absorption Anterior Neuropore Closure Nervous System Development Optic Cup Morphogenesis Involved In Camera-type Eye Development	Protein Localization Regulation Of Defense Response To Virus By Virus Endocytosis Viral Process Cellular Localization Protein Transport Regulation Of Defense Response To Virus Vesicle-mediated Transport Establishment Of Protein Localization Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Establishment Of Localization In Cell Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Intracellular Transport Clathrin Coat Assembly Membrane Organization Receptor-mediated Endocytosis Cellular Protein Localization Organelle Organization Regulation Of Cellular Component Organization Mitotic Spindle Assembly Checkpoint Negative Regulation Of Chromosome Organization Post-Golgi Vesicle-mediated Transport Cellular Response To Growth Factor Stimulus Spindle Assembly Checkpoint Mitotic Spindle Checkpoint Apoptotic Process Clathrin-mediated Endocytosis Response To Growth Factor Negative Regulation Of Chromosome Segregation Programmed Cell Death Cell Cycle Process Cell Differentiation Regulation Of Mitotic Sister Chromatid Separation Cell Development Cell Death Death Regulation Of Signaling Negative Regulation Of Mitotic Nuclear Division Spindle Checkpoint Regulation Of Chromosome Organization Regulation Of Signal Transduction Cellular Protein Complex Assembly Pathway-restricted SMAD Protein Phosphorylation Regulation Of Mitotic Metaphase/anaphase Transition Cellular Response To Organic Substance Negative Regulation Of Protein Catabolic Process Cell Activation Cell Cycle Mitotic Cell Cycle Process
Tagcloud ?			17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Difference) ?			17q 17q12 aa552509 acly amplicon amplifications aoc3 copy custom est ests gains gastriccancer grb7 itga3 jup krt14 lhx1 mkp mln51 mln64 mprl45 pip5k2b q21 rpl27 tags top2a transcribed uncharacterized
Tagcloud (Intersection) ?