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LDLRAP1 and TFAP2A
Number of citations of the paper that reports this interaction (PMID
12221107
)
50
Data Source:
HPRD
(in vitro)
LDLRAP1
TFAP2A
Gene Name
low density lipoprotein receptor adaptor protein 1
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
Image
No pdb structure
Gene Ontology Annotations
Cellular Component
Early Endosome
Cytosol
Neurofilament
Cytoplasmic Side Of Plasma Membrane
Basal Plasma Membrane
AP-1 Adaptor Complex
AP-2 Adaptor Complex
Axon
Recycling Endosome
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Intracellular Membrane-bounded Organelle
Molecular Function
Beta-amyloid Binding
Phosphotyrosine Binding
Protein Binding
Phosphatidylinositol-4,5-bisphosphate Binding
Receptor Signaling Complex Scaffold Activity
Clathrin Binding
Signaling Adaptor Activity
AP-2 Adaptor Complex Binding
Clathrin Adaptor Activity
Low-density Lipoprotein Particle Receptor Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Sequence-specific DNA Binding
RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding
Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity
Core Promoter Proximal Region Sequence-specific DNA Binding
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription
RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription
RNA Polymerase II Transcription Coactivator Activity
RNA Polymerase II Transcription Corepressor Activity
Chromatin Binding
Transcription Coactivator Activity
Protein Binding
Protein Homodimerization Activity
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Protein Dimerization Activity
Biological Process
Transport
Receptor-mediated Endocytosis
Cholesterol Metabolic Process
Positive Regulation Of Signal Transduction
Receptor Internalization
Cholesterol Homeostasis
Amyloid Precursor Protein Metabolic Process
Regulation Of Protein Binding
Positive Regulation Of Receptor-mediated Endocytosis
Regulation Of Establishment Of Protein Localization To Plasma Membrane
Receptor-mediated Endocytosis Of Low-density Lipoprotein Particle Involved In Cholesterol Transport
Positive Regulation Of Cholesterol Metabolic Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Kidney Development
Outflow Tract Morphogenesis
Keratinocyte Development
Optic Vesicle Morphogenesis
Optic Cup Structural Organization
Transcription From RNA Polymerase II Promoter
Sensory Perception Of Sound
Negative Regulation Of Cell Proliferation
Embryonic Pattern Specification
Embryonic Body Morphogenesis
Positive Regulation Of Gene Expression
Retina Layer Formation
Negative Regulation Of Transcription By Competitive Promoter Binding
Neural Crest Cell Development
Anterior Neuropore Closure
Trigeminal Nerve Development
Oculomotor Nerve Formation
Forebrain Neuron Development
Positive Regulation Of Cell Migration
Positive Regulation Of Bone Mineralization
Embryonic Forelimb Morphogenesis
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Inner Ear Morphogenesis
Negative Regulation Of Apoptotic Process
Negative Regulation Of Neuron Apoptotic Process
Positive Regulation Of Neuron Apoptotic Process
Regulation Of Cell Differentiation
Regulation Of Neuron Differentiation
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription From RNA Polymerase II Promoter
Sympathetic Nervous System Development
Embryonic Cranial Skeleton Morphogenesis
Epidermis Morphogenesis
Palate Development
Lens Induction In Camera-type Eye
Face Morphogenesis
Bone Morphogenesis
Eyelid Development In Camera-type Eye
Cornea Development In Camera-type Eye
Positive Regulation Of Tooth Mineralization
Cellular Response To Iron Ion
Basement Membrane Organization
Metanephric Nephron Development
Negative Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
Drugs
Diseases
GWAS
Cholesterol, total (
20686565
)
LDL cholesterol (
20686565
)
Protein-Protein Interactions
7 interactors:
AP2B1
APP
CLTC
LDLR
LRP2
OBFC1
TFAP2A
30 interactors:
APC
CASP1
CASP3
CASP6
CITED2
CITED4
CLTC
CTNNB1
DEK
EP300
EPN2
EPS15
GSTO2
HIP1
LDLRAP1
MAGI1
MKRN3
MYC
NPM1
PPARG
RB1
SP1
SRA1
SUMO4
SYT1
TP53
UBE2I
WWP1
WWP2
YBX1
Entrez ID
26119
7020
HPRD ID
05765
00128
Ensembl ID
ENSG00000157978
ENSG00000137203
Uniprot IDs
B3KR97
Q5SW96
P05549
PDB IDs
2G30
Enriched GO Terms of Interacting Partners
?
Endocytosis
Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Regulation Of ERBB Signaling Pathway
Receptor-mediated Endocytosis
Vesicle-mediated Transport
Steroid Metabolic Process
Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway
Negative Regulation Of ERBB Signaling Pathway
Response To Light Stimulus
Alcohol Metabolic Process
Phototransduction, Visible Light
Forebrain Development
Response To Radiation
Retinoid Metabolic Process
Diterpenoid Metabolic Process
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II
Detection Of Visible Light
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Optic Cup Structural Organization
Phototransduction
Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II
Detection Of Light Stimulus
Cholesterol Metabolic Process
Isoprenoid Metabolic Process
Optic Vesicle Morphogenesis
Oculomotor Nerve Formation
Synaptic Growth At Neuromuscular Junction
Sterol Metabolic Process
Positive Regulation Of Cellular Biosynthetic Process
Cholesterol Import
Regulation Of Phosphatidylcholine Catabolic Process
Collateral Sprouting In Absence Of Injury
Positive Regulation Of Tooth Mineralization
Negative Regulation Of Hyaluronan Biosynthetic Process
Response To External Stimulus
Brain Development
Detection Of Abiotic Stimulus
Oculomotor Nerve Development
Head Development
Collateral Sprouting
Axon Midline Choice Point Recognition
Smooth Endoplasmic Reticulum Calcium Ion Homeostasis
Axon Choice Point Recognition
Antigen Processing And Presentation Of Peptide Antigen
Neuron Development
Central Nervous System Development
Intestinal Cholesterol Absorption
Anterior Neuropore Closure
Nervous System Development
Optic Cup Morphogenesis Involved In Camera-type Eye Development
Cell Death
Death
Apoptotic Process
Programmed Cell Death
Negative Regulation Of Cellular Metabolic Process
Regulation Of Nitrogen Compound Metabolic Process
Viral Process
Negative Regulation Of Transcription From RNA Polymerase II Promoter
Negative Regulation Of Biosynthetic Process
Execution Phase Of Apoptosis
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Nucleic Acid-templated Transcription
Glial Cell Apoptotic Process
Negative Regulation Of RNA Biosynthetic Process
Positive Regulation Of Metabolic Process
Regulation Of Signaling
Regulation Of Signal Transduction
Negative Regulation Of Gene Expression
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Regulation Of Metabolic Process
Positive Regulation Of Apoptotic Process
Positive Regulation Of Programmed Cell Death
Positive Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Cell Death
Positive Regulation Of Endopeptidase Activity
Regulation Of Apoptotic Process
Positive Regulation Of Cellular Metabolic Process
Regulation Of Transcription From RNA Polymerase II Promoter
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Cell Cycle
Positive Regulation Of Peptidase Activity
Cellular Component Disassembly Involved In Execution Phase Of Apoptosis
Negative Regulation Of Cell Proliferation
Regulation Of Cell Cycle
Neuron Death
Positive Regulation Of Gene Expression
Regulation Of Cell Death
Transcription, DNA-templated
Positive Regulation Of Protein Metabolic Process
Regulation Of Cellular Component Organization
Immune System Development
Positive Regulation Of Proteolysis
Positive Regulation Of Cellular Biosynthetic Process
Regulation Of Cellular Protein Metabolic Process
Regulation Of Transcription, DNA-templated
RNA Biosynthetic Process
Regulation Of Nucleic Acid-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Positive Regulation Of Transcription, DNA-templated
Tagcloud
?
blastocysts
bts
cdh3
cdx2
chir99021
continually
cyp11a1
dome
elf5
eomes
ets2
feeders
gcm1
gdf3
hand1
hsd17b1
mash2
nanog
oct4
pd0325901
pparg
smarca4
sox2
ssea
tdk
tead4
teratomas
thap11
tscs
Tagcloud (Difference)
?
blastocysts
bts
cdh3
cdx2
chir99021
continually
cyp11a1
dome
elf5
eomes
ets2
feeders
gcm1
gdf3
hand1
hsd17b1
mash2
nanog
oct4
pd0325901
pparg
smarca4
sox2
ssea
tdk
tead4
teratomas
thap11
tscs
Tagcloud (Intersection)
?