LDLRAP1 and C6orf58

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)

		LDLRAP1	C6orf58
Description		low density lipoprotein receptor adaptor protein 1	chromosome 6 open reading frame 58
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Early Endosome Cytosol Neurofilament Plasma Membrane Cytoplasmic Side Of Plasma Membrane Basal Plasma Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Recycling Endosome	Extracellular Region Extracellular Space Extracellular Exosome
	Molecular Function	Amyloid-beta Binding Phosphotyrosine Residue Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Signaling Receptor Complex Adaptor Activity Clathrin Binding Signaling Adaptor Activity AP-2 Adaptor Complex Binding Clathrin Adaptor Activity AP-1 Adaptor Complex Binding Low-density Lipoprotein Particle Receptor Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Endocytosis Receptor-mediated Endocytosis Steroid Metabolic Process Cholesterol Metabolic Process Cholesterol Transport Receptor Internalization Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Amyloid Precursor Protein Metabolic Process Regulation Of Protein Binding Positive Regulation Of Receptor-mediated Endocytosis Cellular Response To Cytokine Stimulus Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Low-density Lipoprotein Particle Clearance Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport
Pathways		Vitamin D (calciferol) metabolism Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis Chylomicron clearance LDL clearance Transport of RCbl within the body
Drugs
Diseases
GWAS		Cholesterol, total ( 20686565 24097068 25961943) LDL cholesterol ( 20686565 24097068 25961943) LDL cholesterol levels ( 28334899) Mean platelet volume ( 27863252 32888494) Platelet count ( 27863252 32888494) Platelet distribution width ( 32888494) Total cholesterol levels ( 28334899)	Asthma ( 31959851) Hepcidin/ferritin ratio ( 27846281) Urinary albumin-to-creatinine ratio in non-diabetics ( 26631737) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 28552196 34021172)
Interacting Genes		18 interacting genes: AP1B1 AP2B1 APP C6orf58 CLTC ESPNL FHL2 HOXC8 HOXD8 LDLR LRP2 MAGEA4 MAPK8IP3 NOTO PAX5 PSD4 SNCA TFAP2A	1 interacting genes: LDLRAP1
Entrez ID		26119	352999
HPRD ID		05765
Ensembl ID		ENSG00000157978	ENSG00000184530
Uniprot IDs		B3KR97 Q5SW96	Q6P5S2
PDB IDs		2G30
Enriched GO Terms of Interacting Partners?		Clathrin-coated Pit Endolysosome Membrane Clathrin-coated Endocytic Vesicle Membrane Receptor-mediated Endocytosis Negative Regulation Of Transcription By RNA Polymerase II Amyloid-beta Clearance Endocytosis Skeletal System Morphogenesis Vesicle-mediated Transport Positive Regulation Of Lysosomal Protein Catabolic Process Artery Development Clathrin Coat Kidney Development Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process Positive Regulation Of Protein Catabolic Process In The Vacuole Import Into Cell Negative Regulation Of RNA Metabolic Process Pattern Specification Process Receptor Internalization Anatomical Structure Morphogenesis Regulation Of Lysosomal Protein Catabolic Process Clathrin Adaptor Complex Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Lysosome Low-density Lipoprotein Particle Low-density Lipoprotein Particle Receptor Activity Negative Regulation Of Metabolic Process Regulation Of Amyloid Fibril Formation Regionalization Transcytosis Negative Regulation Of Apoptotic Process Trans-Golgi Network Membrane Clathrin Coat Assembly Regulation Of Neurotransmitter Uptake Negative Regulation Of Programmed Cell Death Developmental Process Endosome Lumen Clathrin-coated Endocytic Vesicle Cellular Response To Copper Ion Regulation Of Receptor Recycling Coronary Vasculature Development Regulation Of Presynapse Organization Regulation Of Long-term Neuronal Synaptic Plasticity Low-density Lipoprotein Particle Receptor Binding Regulation Of Presynapse Assembly Synaptic Vesicle	Positive Regulation Of Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Low-density Lipoprotein Particle Clearance Receptor-mediated Endocytosis Involved In Cholesterol Transport Positive Regulation Of Intracellular Lipid Transport AP-1 Adaptor Complex Binding Positive Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Cholesterol Transport Regulation Of Intracellular Lipid Transport AP-2 Adaptor Complex Binding Neurofilament Low-density Lipoprotein Particle Clearance Clathrin Adaptor Activity Regulation Of Low-density Lipoprotein Particle Clearance Low-density Lipoprotein Particle Receptor Binding Amyloid Precursor Protein Metabolic Process Plasma Lipoprotein Particle Clearance Positive Regulation Of Cholesterol Metabolic Process Signaling Receptor Complex Adaptor Activity Clathrin Binding Positive Regulation Of Cholesterol Transport Regulation Of Protein Binding Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Steroid Metabolic Process Phosphotyrosine Residue Binding Regulation Of Cholesterol Metabolic Process Positive Regulation Of Receptor-mediated Endocytosis Cholesterol Transport Basal Plasma Membrane Regulation Of Cholesterol Transport Clathrin-coated Endocytic Vesicle Membrane Receptor Internalization Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Phosphatidylinositol-4,5-bisphosphate Binding Signaling Adaptor Activity Sterol Transport Positive Regulation Of Lipid Transport Amyloid-beta Binding Positive Regulation Of Smooth Muscle Cell Proliferation Sterol Homeostasis Cholesterol Homeostasis Cytoplasmic Side Of Plasma Membrane Regulation Of Steroid Metabolic Process Cholesterol Metabolic Process Regulation Of Protein Localization To Plasma Membrane Sterol Metabolic Process Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Lipid Metabolic Process Recycling Endosome Positive Regulation Of Intracellular Transport Regulation Of Lipid Transport
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