AP1M2 and MAST1

Number of citations of the paper that reports this interaction (PubMedID 21163940)
58

Data Source:
BioGRID (two hybrid)

		AP1M2	MAST1
Description		adaptor related protein complex 1 subunit mu 2	microtubule associated serine/threonine kinase 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane	Cytoplasm Cytoskeleton Plasma Membrane Microtubule Cytoskeleton Membrane Axon Dendrite Cell Projection Neuron Projection Neuronal Cell Body
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Nucleotide Binding Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Targeting Intracellular Protein Transport Vesicle Targeting Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Establishment Of Localization In Cell Basolateral Protein Secretion	Protein Phosphorylation Cytoskeleton Organization Brain Development Developmental Process Intracellular Signal Transduction
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis
Drugs			Fostamatinib
Diseases
GWAS		Bipolar disorder ( 31043756) Lymphocyte percentage of white cells ( 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Platelet count ( 27863252) Plateletcrit ( 27863252 32888494) Red cell distribution width ( 27863252 28957414 32888494)	High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252 32888494) Red blood cell count ( 29403010) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		20 interacting genes: A2M AP1B1 AP1G1 AP1M1 AP1S1 AP2B1 APP BLMH ECSIT EHD2 GAK LDLR LOXL4 MAST1 NDRG1 PSEN1 PVR RAB3A RAB3D TGOLN2	41 interacting genes: A2M ACE2 AP1M2 APOE APP BLMH CDK5 CYP2C8 CYP2C9 DNAJB1 ECSIT EGFR ELAVL3 EXOC6 EXOSC1 FBXL12 FBXW4 GCDH IFIT3 IFIT5 LONP1 LOXL4 NOS3 OGA PAXIP1 PRAM1 PRDX2 PSEN2 PTEN RAB3A RAB3D RAD23A RNF32 RNLS RPP30 RPS6KA1 SNTA1 SNTB2 STAMBPL1 TIAM1 VANGL2
Entrez ID		10053	22983
HPRD ID		06296	17469
Ensembl ID		ENSG00000129354	ENSG00000105613
Uniprot IDs		Q53GI5 Q9Y6Q5	Q9Y2H9
PDB IDs			2M9X 3PS4
Enriched GO Terms of Interacting Partners?		AP-1 Adaptor Complex Early Endosome Melanosome Assembly Clathrin Adaptor Activity Basolateral Protein Secretion Platelet Dense Granule Organization Clathrin-coated Pit Vesicle-mediated Transport Membrane Coat Melanosome Organization Pigment Granule Organization Trans-Golgi Network Membrane Cytoplasmic Vesicle Clathrin Adaptor Complex Import Into Cell Intracellular Transport Establishment Of Localization In Cell Synaptic Vesicle Endocytosis Secretory Granule Organization Regulation Of Amyloid Fibril Formation GTP-dependent Protein Binding Regulation Of Vesicle-mediated Transport Cellular Localization Lysosomal Membrane Secretion By Cell Presynapse Astrocyte Activation Involved In Immune Response Clathrin Binding Clathrin-coated Vesicle Membrane Golgi Apparatus Protein Localization To Extracellular Region Protein Secretion Establishment Of Protein Localization To Extracellular Region Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Intracellular Protein Localization Endosome Protein Transport Secretion Positive Regulation Of Regulated Secretory Pathway Vesicle Organization Positive Regulation Of Transport Cytoplasmic Vesicle Membrane Receptor-mediated Endocytosis Endosome To Melanosome Transport Establishment Of Protein Localization Golgi To Lysosome Transport Clathrin-coated Endocytic Vesicle Membrane Clathrin-coated Vesicle	Lipoprotein Particle Acetylcholine Receptor Activator Activity Negative Regulation Of Smooth Muscle Cell Proliferation Caffeine Oxidase Activity Intermediate-density Lipoprotein Particle Positive Regulation Of Amyloid Fibril Formation Chemical Synaptic Transmission Catabolic Process Cytosol Regulation Of Calcium Ion-dependent Exocytosis Of Neurotransmitter Trans-synaptic Signaling Oxidative Demethylation Synaptic Signaling Cellular Response To Amyloid-beta Positive Regulation Of Regulated Secretory Pathway Regulation Of Regulated Secretory Pathway Omega-hydroxylase P450 Pathway Oxidoreductase Activity Arachidonate Epoxygenase Activity Regulation Of Neuronal Synaptic Plasticity Regulation Of Wound Healing Negative Regulation Of Long-term Synaptic Potentiation Regulation Of System Process Regulation Of Blood Circulation Demethylation Regulation Of Dendritic Spine Maintenance Response To Amyloid-beta Regulation Of Smooth Muscle Cell Proliferation Learning Or Memory Axonogenesis Epoxygenase P450 Pathway Low-density Lipoprotein Particle Removal Of Superoxide Radicals Negative Regulation Of Wound Healing Regulation Of Blood Coagulation Positive Regulation Of Membrane Protein Ectodomain Proteolysis Myosin V Binding Dystrophin-associated Glycoprotein Complex Regulation Of Hemostasis Heparan Sulfate Proteoglycan Binding Intracellular Signaling Cassette Regulation Of Amyloid Fibril Formation Regulation Of Response To Wounding Negative Regulation Of Platelet Activation Cognition Cellular Oxidant Detoxification Regulation Of Transport Ubiquitin-specific Protease Binding Very-low-density Lipoprotein Particle Regulation Of Amyloid-beta Clearance
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