AP1M2 and BLMH

Number of citations: 58 (PubMedID 21163940)
Data Source: BioGRID (two hybrid)

		AP1M2	BLMH
Name		adaptor related protein complex 1 subunit mu 2	bleomycin hydrolase
Structure		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Golgi Apparatus Cytosol Membrane AP-1 Adaptor Complex Clathrin Adaptor Complex Clathrin-coated Vesicle Cytoplasmic Vesicle Membrane Clathrin-coated Vesicle Membrane Cytoplasmic Vesicle Trans-Golgi Network Membrane	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Protein Binding Clathrin Adaptor Activity	Aminopeptidase Activity Carboxypeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Identical Protein Binding Cysteine-type Aminopeptidase Activity
	Biological Process	Protein Targeting Intracellular Protein Transport Vesicle Targeting Protein Transport Vesicle-mediated Transport Establishment Of Protein Localization Establishment Of Localization In Cell Basolateral Protein Secretion	Protein Polyubiquitination Proteolysis Response To Xenobiotic Stimulus Response To Toxic Substance Homocysteine Catabolic Process
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Antigen processing: Ubiquitination & Proteasome degradation
GWAS		Bipolar disorder ( 31043756 ) Lymphocyte percentage of white cells ( 27863252 ) Mean reticulocyte volume ( 32888494 ) Mean spheric corpuscular volume ( 32888494 ) Platelet count ( 27863252 ) Plateletcrit ( 27863252 32888494 ) Red cell distribution width ( 27863252 28957414 32888494 )	No GWAS studies recorded
Novel Interactors		1 novel interactors: CDK12	None recorded
Interacting Genes		20 interacting genes: A2M AP1B1 AP1G1 AP1M1 AP1S1 AP2B1 APP BLMH ECSIT EHD2 GAK LDLR LOXL4 MAST1 NDRG1 PSEN1 PVR RAB3A RAB3D TGOLN2	20 interacting genes: AP1M2 APP CDC42 CEBPA CYP2C8 ECSIT KBTBD7 MAST1 NTAQ1 NXF1 PDPK1 PGLS RNF32 RPL11 RPL29 TNPO2 TNPO3 TRIM47 TRIO UBE2I
Entrez ID		10053	642
HPRD ID		06296	03870
Ensembl ID		ENSG00000129354	ENSG00000108578
Uniprot IDs		Q53GI5 Q9Y6Q5	Q13867
PDB IDs		Not available	1CB5 2CB5 7V5L 7V5S 7V5T 7XF9
GO Terms Enriched among Interactors		AP-1 Adaptor Complex Early Endosome Melanosome Assembly Clathrin Adaptor Activity Basolateral Protein Secretion Platelet Dense Granule Organization Clathrin-coated Pit Vesicle-mediated Transport Membrane Coat Melanosome Organization Pigment Granule Organization Trans-Golgi Network Membrane Cytoplasmic Vesicle Clathrin Adaptor Complex Import Into Cell Intracellular Transport Establishment Of Localization In Cell Synaptic Vesicle Endocytosis Secretory Granule Organization Regulation Of Amyloid Fibril Formation GTP-dependent Protein Binding Regulation Of Vesicle-mediated Transport Cellular Localization Lysosomal Membrane Secretion By Cell Presynapse Astrocyte Activation Involved In Immune Response Clathrin Binding Clathrin-coated Vesicle Membrane Golgi Apparatus Protein Localization To Extracellular Region Protein Secretion Establishment Of Protein Localization To Extracellular Region Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Intracellular Protein Localization Endosome Protein Transport Secretion Positive Regulation Of Regulated Secretory Pathway Vesicle Organization Positive Regulation Of Transport Cytoplasmic Vesicle Membrane Receptor-mediated Endocytosis Endosome To Melanosome Transport Establishment Of Protein Localization Golgi To Lysosome Transport Clathrin-coated Endocytic Vesicle Membrane Clathrin-coated Vesicle	Cytosol Cytoplasm Postsynapse Intracellular Transport Nuclear Transport Nucleocytoplasmic Transport Nuclear Import Signal Receptor Activity