LAMB2 and PLEKHA5

Number of citations: 36 (PubMedID 20936779)
Data Source: BioGRID (two hybrid)

		LAMB2	PLEKHA5
Name		laminin subunit beta 2	pleckstrin homology domain containing A5
Structure		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Laminin-3 Complex Endoplasmic Reticulum Lumen Extracellular Matrix Neuromuscular Junction Synaptic Cleft Laminin Complex Laminin-11 Complex Synapse Extracellular Exosome Protein Complex Involved In Cell-matrix Adhesion	Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse
	Molecular Function	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding Structural Constituent Of Synapse-associated Extracellular Matrix	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Cell Morphogenesis Cell Adhesion Axon Guidance Neuromuscular Junction Development Visual Perception Astrocyte Development Schwann Cell Development Neuron Projection Development Positive Regulation Of Cell Adhesion Axon Extension Involved In Regeneration Synapse Organization Positive Regulation Of Muscle Cell Differentiation Retina Development In Camera-type Eye Metanephric Podocyte Development Metanephric Glomerular Basement Membrane Development Regulation Of Basement Membrane Organization Positive Regulation Of Integrin-mediated Signaling Pathway	Reproductive System Development
Pathways		Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation Attachment of bacteria to epithelial cells Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC) Developmental Lineage of Pancreatic Ductal Cells	Synthesis of PIPs at the plasma membrane
Diseases		Pierson syndrome	None
GWAS		Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Inflammatory bowel disease ( 28067908 ) Mood instability ( 31168069 ) Myocardial infarction ( 33532862 ) PR interval ( 32439900 ) Resting heart rate ( 27798624 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 28067908 ) Waist circumference adjusted for body mass index ( 34021172 )	Adult body size ( 32376654 ) Age at first sexual intercourse ( 34211149 ) Chronic mountain sickness ( 31417607 ) Daytime sleep phenotypes ( 27126917 ) Gut microbiota (bacterial taxa) ( 27694959 ) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223 ) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848 ) Platelet reactivity in response to clopidogrel treatment ( 32472697 ) Thalamus volume ( 31530798 )
Novel Interactors		1 novel interactors: CTNNB1	5 novel interactors: ADK BET1 H2AJ RECQL SPIRE1
Interacting Genes		12 interacting genes: ATXN7 CIP2A HOXA1 KPNA2 ORC5 PIK3R2 PLEKHA5 RBL1 STAT3 STIP1 TSR2 ZNF512B	30 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX MTCL2 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG
Entrez ID		3913	54477
HPRD ID		01034	09684
Ensembl ID		ENSG00000172037	ENSG00000052126
Uniprot IDs		P55268	A0A8V8TQ09 A0A8V8TQJ8 A0A9L9PX43 Q9HAU0
PDB IDs		Not available	2DKP
GO Terms Enriched among Interactors		None	Structural Constituent Of Cytoskeleton Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Cytoskeleton Cytoskeleton Organization Double-stranded DNA Helicase Activity Intermediate Filament Organization Intermediate Filament Cadherin Binding Supramolecular Fiber Organization Extracellular Exosome Spectrin Vesicle Cytoskeletal Trafficking Contractile Muscle Fiber Centriole-centriole Cohesion Centriole Cytoskeletal Protein Binding Costamere Structural Molecule Activity Intracellular Protein Localization Ankyrin Binding Cytoskeleton-dependent Intracellular Transport Actin Cytoskeleton Organization Actin Filament Binding Purine Nucleoside Metabolic Process Epithelial Cell Differentiation Microtubule Anchoring Protein Localization To Centrosome Establishment Of Vesicle Localization Actin Filament-based Process Cytosol DATP Biosynthetic Process Adenosine Kinase Activity Membrane Organization Sarcolemma Metanephric Glomerular Basement Membrane Development MLL1 Complex Microtubule Binding Cilium Assembly Vesicle Localization Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Actin Filament Capping Establishment Of Organelle Localization Regulation Of Protein-containing Complex Disassembly