PLEKHA5 and ADK

		PLEKHA5	ADK
Description		pleckstrin homology domain containing A5	adenosine kinase
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Nucleotide Binding RNA Binding Adenosine Kinase Activity Deoxyadenosine Kinase Activity ATP Binding Kinase Activity Transferase Activity Metal Ion Binding
	Biological Process	Reproductive System Development	Purine Nucleobase Metabolic Process Purine Ribonucleoside Salvage DATP Biosynthetic Process Ribonucleoside Monophosphate Biosynthetic Process GMP Salvage AMP Salvage DAMP Salvage
Pathways		Synthesis of PIPs at the plasma membrane	Purine salvage Ribavirin ADME
Drugs			Adenosine phosphate 7-(5-DEOXY-BETA-D-RIBOFURANOSYL)-5-IODO-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE 5-[4-(DIMETHYLAMINO)PHENYL]-6-[(6-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYNYL]PYRIMIDIN-4-AMINE
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)	Adult body size ( 32376654) Cardiac troponin-I levels ( 31014085) Diverticular disease ( 30177863) Drug experimentation measurement ( 30718321) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Hypospadias ( 25108383) Lymphocyte count ( 32888494) Permanent tooth development ( 21931568) Platelet count ( 32888494) Plateletcrit ( 32888494) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Refractive error ( 32231278) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systolic blood pressure ( 30578418)
Interacting Genes		30 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX MTCL2 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG	2 interacting genes: FICD SRD5A3
Entrez ID		54477	132
HPRD ID		09684	00039
Ensembl ID		ENSG00000052126	ENSG00000156110
Uniprot IDs		A0A8V8TQ09 A0A8V8TQJ8 A0A9L9PX43 Q9HAU0	A0A140VJE0 A0A5F9ZH31 A0A5F9ZH72 A0A5F9ZHJ1 P55263
PDB IDs		2DKP	1BX4 2I6A 2I6B 4O1L
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Cytoskeleton Cytoskeleton Organization Double-stranded DNA Helicase Activity Intermediate Filament Organization Intermediate Filament Cadherin Binding Supramolecular Fiber Organization Extracellular Exosome Spectrin Vesicle Cytoskeletal Trafficking Contractile Muscle Fiber Centriole-centriole Cohesion Centriole Cytoskeletal Protein Binding Costamere Structural Molecule Activity Intracellular Protein Localization Ankyrin Binding Cytoskeleton-dependent Intracellular Transport Actin Cytoskeleton Organization Actin Filament Binding Purine Nucleoside Metabolic Process Epithelial Cell Differentiation Microtubule Anchoring Protein Localization To Centrosome Establishment Of Vesicle Localization Actin Filament-based Process Cytosol DATP Biosynthetic Process Adenosine Kinase Activity Membrane Organization Sarcolemma Metanephric Glomerular Basement Membrane Development MLL1 Complex Microtubule Binding Cilium Assembly Vesicle Localization Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Actin Filament Capping Establishment Of Organelle Localization Regulation Of Protein-containing Complex Disassembly	Protein Adenylylhydrolase Activity AMPylase Activity Protein Adenylylation Protein Deadenylylation Polyprenol Reductase Activity Polyprenal Reductase Activity 3-oxo-5-alpha-steroid 4-dehydrogenase (NADP+) Activity 3-oxo-5-alpha-steroid 4-dehydrogenase Activity Polyprenol Catabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Oxidoreductase Activity, Acting On The CH-CH Group Of Donors, NAD Or NADP As Acceptor Androgen Biosynthetic Process Negative Regulation Of GTPase Activity Regulation Of IRE1-mediated Unfolded Protein Response Dolichol-linked Oligosaccharide Biosynthetic Process Phosphatidylinositol-5-phosphate Binding Reproductive System Development Oxidoreductase Activity, Acting On The CH-CH Group Of Donors Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Androgen Metabolic Process Steroid Hormone Biosynthetic Process Alcohol Catabolic Process Negative Regulation Of Hydrolase Activity Regulation Of Endoplasmic Reticulum Unfolded Protein Response Hormone Biosynthetic Process Phosphatidylinositol-3-phosphate Binding Hsp70 Protein Binding Endoplasmic Reticulum Membrane Response To Unfolded Protein Steroid Biosynthetic Process Regulation Of Response To Endoplasmic Reticulum Stress Protein-folding Chaperone Binding Nucleotidyltransferase Activity Isoprenoid Metabolic Process
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