LAMB2 and ORC5

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		LAMB2	ORC5
Gene Name		laminin, beta 2 (laminin S)	origin recognition complex, subunit 5
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Basement Membrane Basal Lamina Laminin-3 Complex Extracellular Matrix Laminin-11 Complex Synapse Extracellular Vesicular Exosome	Origin Recognition Complex Nucleus Nucleoplasm Nuclear Origin Of Replication Recognition Complex Cytoplasm
	Molecular Function	Integrin Binding Structural Molecule Activity	Nucleotide Binding Molecular_function DNA Replication Origin Binding Protein Binding ATP Binding
	Biological Process	Cell Adhesion Axon Guidance Neuromuscular Junction Development Visual Perception Astrocyte Development Schwann Cell Development Extracellular Matrix Organization Axon Extension Involved In Regeneration Retina Development In Camera-type Eye Metanephric Glomerular Visceral Epithelial Cell Development Metanephric Glomerular Basement Membrane Development	G1/S Transition Of Mitotic Cell Cycle Mitotic Cell Cycle DNA Replication DNA Replication Initiation
Pathways		Laminin interactions ECM proteoglycans Non-integrin membrane-ECM interactions	G2/M Checkpoints Activation of the pre-replicative complex Activation of the pre-replicative complex Orc1 removal from chromatin Assembly of the pre-replicative complex Activation of ATR in response to replication stress G1/S Transition Assembly of the ORC complex at the origin of replication Removal of licensing factors from origins Mitotic G1-G1/S phases Switching of origins to a post-replicative state E2F mediated regulation of DNA replication Synthesis of DNA DNA Replication Pre-Initiation Regulation of DNA replication M/G1 Transition S Phase CDC6 association with the ORC:origin complex Cell Cycle, Mitotic Orc1 removal from chromatin E2F-enabled inhibition of pre-replication complex formation Cell Cycle Checkpoints Association of licensing factors with the pre-replicative complex CDT1 association with the CDC6:ORC:origin complex
Drugs
Diseases
GWAS
Protein-Protein Interactions		8 interactors: ATXN7 KPNA2 ORC5 PIK3R2 PLEKHA5 RBL1 STAT3 ZNF512B	29 interactors: CALCOCO2 CDC45 CDC5L CDC6 CDC7 DBF4 DMRTA1 HIST3H3 HIST4H4 KRT18 LAMB2 MCM2 MCM3 MCM4 MCM5 MCM7 NIF3L1 NONO ORC1 ORC2 ORC3 ORC4 ORC6 RPA2 SIPA1L2 STAB1 TAX1BP1 TXNDC11 UBQLN4
Entrez ID		3913	5001
HPRD ID		01034	09086
Ensembl ID		ENSG00000172037	ENSG00000164815
Uniprot IDs		P55268	A4D0P7 O43913 Q53FC8
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Lipid Kinase Activity Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Viral Process Protein Import Into Nucleus Nuclear Import Cellular Response To Growth Factor Stimulus Response To Growth Factor Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Protein Import Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Protein Localization To Nucleus Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Glucose Homeostasis Cellular Response To Organic Substance Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Nitrogen Compound Metabolic Process Negative Regulation Of Glycolytic Process Cellular Macromolecule Biosynthetic Process Radial Glial Cell Differentiation Macromolecule Biosynthetic Process Nucleocytoplasmic Transport Nuclear Transport Regulation Of Lipid Metabolic Process Transcription, DNA-templated Cellular Response To Peptide Hormone Stimulus Interleukin-6-mediated Signaling Pathway Cellular Response To Peptide RNA Biosynthetic Process Establishment Of Protein Localization To Organelle Response To Organic Substance Regulation Of Transcription, DNA-templated Histone Deubiquitination Positive Regulation Of Cellular Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process NLS-bearing Protein Import Into Nucleus JAK-STAT Cascade Involved In Growth Hormone Signaling Pathway Regulation Of Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphorylation	G1/S Transition Of Mitotic Cell Cycle DNA Replication Initiation Mitotic Cell Cycle Phase Transition DNA Replication Cell Cycle Phase Transition DNA-dependent DNA Replication DNA Metabolic Process Mitotic Cell Cycle Mitotic Cell Cycle Process Cell Cycle DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation Cell Cycle Process DNA Duplex Unwinding DNA Geometric Change Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Nitrogen Compound Metabolic Process DNA Conformation Change Biosynthetic Process DNA Unwinding Involved In DNA Replication Double-strand Break Repair Via Break-induced Replication Chromosome Organization Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Positive Regulation Of Mitotic Cell Cycle Phase Transition Protein-DNA Complex Assembly Positive Regulation Of Cell Cycle Phase Transition Cellular Response To Stress Cellular Response To DNA Damage Stimulus DNA Replication Checkpoint Telomere Maintenance Double-strand Break Repair Via Homologous Recombination Recombinational Repair Regulation Of Mitotic Cell Cycle Phase Transition Cell Cycle Checkpoint DNA Recombination Cellular Metabolic Process Regulation Of Cell Cycle Process Response To Stress Nuclear DNA Replication Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle G1/S Phase Transition Cellular Response To Epidermal Growth Factor Stimulus Regulation Of G1/S Transition Of Mitotic Cell Cycle
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