PLEKHA5 and RECQL

		PLEKHA5	RECQL
Description		pleckstrin homology domain containing A5	RecQ like helicase
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Postsynaptic Density Membrane Glutamatergic Synapse	Nucleus Nucleoplasm Chromosome Cytoplasm Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity Helicase Activity Protein Binding ATP Binding Four-way Junction Helicase Activity Hydrolase Activity Isomerase Activity ATP Hydrolysis Activity Double-stranded DNA Helicase Activity 3'-5' DNA Helicase Activity Metal Ion Binding DNA/DNA Annealing Activity
	Biological Process	Reproductive System Development	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair DNA Recombination Replication Fork Processing
Pathways		Synthesis of PIPs at the plasma membrane
Drugs
Diseases
GWAS		Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Chronic mountain sickness ( 31417607) Daytime sleep phenotypes ( 27126917) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Pharmacokinetics of antiepileptic drugs in severe mental disorder (concentration drug ratio) ( 25944848) Platelet reactivity in response to clopidogrel treatment ( 32472697) Thalamus volume ( 31530798)	Blood protein levels ( 30072576)
Interacting Genes		30 interacting genes: ARHGEF9 BLOC1S6 CCDC186 CCDC88B CCDC92 CEP250 CEP350 DES EVPL EXTL3 KANSL1 KIF3A KRT19 KRT20 KTN1 LAMB2 LSM4 MAX MTCL2 PLEC PLEKHA6 PPP1R13B PROM1 SH3BP5L SPTAN1 SPTBN1 SRPK2 UPF1 WASH2P YWHAG	8 interacting genes: CEBPA E2F4 KPNA2 KPNA4 LINC00632 NEIL3 RPA1 UBC
Entrez ID		54477	5965
HPRD ID		09684	02762
Ensembl ID		ENSG00000052126	ENSG00000004700
Uniprot IDs		A0A8V8TQ09 A0A8V8TQJ8 A0A9L9PX43 Q9HAU0	P46063
PDB IDs		2DKP	2V1X 2WWY 4U7D 6JTZ 8YRS
Enriched GO Terms of Interacting Partners?		Structural Constituent Of Cytoskeleton Cytoskeleton Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Organelle Organization Intermediate Filament Cytoskeleton Cytoskeleton Organization Double-stranded DNA Helicase Activity Intermediate Filament Organization Intermediate Filament Cadherin Binding Supramolecular Fiber Organization Extracellular Exosome Spectrin Vesicle Cytoskeletal Trafficking Contractile Muscle Fiber Centriole-centriole Cohesion Centriole Cytoskeletal Protein Binding Costamere Structural Molecule Activity Intracellular Protein Localization Ankyrin Binding Cytoskeleton-dependent Intracellular Transport Actin Cytoskeleton Organization Actin Filament Binding Purine Nucleoside Metabolic Process Epithelial Cell Differentiation Microtubule Anchoring Protein Localization To Centrosome Establishment Of Vesicle Localization Actin Filament-based Process Cytosol DATP Biosynthetic Process Adenosine Kinase Activity Membrane Organization Sarcolemma Metanephric Glomerular Basement Membrane Development MLL1 Complex Microtubule Binding Cilium Assembly Vesicle Localization Bradykinin Biosynthetic Process Circadian Sleep/wake Cycle Actin Filament Capping Establishment Of Organelle Localization Regulation Of Protein-containing Complex Disassembly	NLS-dependent Protein Nuclear Import Complex Nucleoplasm NLS-bearing Protein Import Into Nucleus Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity Base-excision Repair RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Hippo Signaling Male Germ Cell Nucleus Ventral Spinal Cord Interneuron Fate Determination Type B Pancreatic Cell Fate Commitment MCM Complex Binding Damaged DNA Binding Response To Vitamin B2 C/EBP Complex Entry Of Viral Genome Into Host Nucleus Through Nuclear Pore Complex Via Importin Pancreatic A Cell Fate Commitment Pancreatic PP Cell Fate Commitment Cell Development Chromatin Binding CHOP-C/EBP Complex Histone Deacetylase Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific White Fat Cell Proliferation RNA Polymerase II Transcription Regulator Complex Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Epithelial Cell Development Import Into Nucleus Protein Import Into Nucleus Viral Penetration Into Host Nucleus Spinal Cord Oligodendrocyte Cell Differentiation Oligodendrocyte Cell Fate Specification Spinal Cord Oligodendrocyte Cell Fate Specification Single-stranded Telomeric DNA Binding Single-stranded DNA Binding Depurination
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