SUMO1P1 and ACTN3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		SUMO1P1	ACTN3
Description		SUMO1 pseudogene 1	actinin alpha 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus PML Body	Cytoplasm Cytosol Actin Filament Plasma Membrane Brush Border Focal Adhesion Actin Cytoskeleton Sarcomere Z Disc Cell Junction Cortical Actin Cytoskeleton Pseudopodium Cell Projection Extracellular Exosome
	Molecular Function	Protein Binding Transcription Factor Binding Protein Tag Activity Identical Protein Binding Ubiquitin-like Protein Ligase Binding	Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Transmembrane Transporter Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Protein Sumoylation PML Body Organization	Regulation Of The Force Of Skeletal Muscle Contraction Skeletal Muscle Atrophy Transition Between Fast And Slow Fiber Response To Denervation Involved In Regulation Of Muscle Adaptation Actin Cytoskeleton Organization Positive Regulation Of Fast-twitch Skeletal Muscle Fiber Contraction Regulation Of Apoptotic Process Negative Regulation Of Glycolytic Process Focal Adhesion Assembly Positive Regulation Of Skeletal Muscle Tissue Growth Positive Regulation Of Skeletal Muscle Fiber Development Muscle Cell Development Bone Morphogenesis Negative Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Muscle System Process Negative Regulation Of Oxidative Phosphorylation Negative Regulation Of Cold-induced Thermogenesis Positive Regulation Of Bone Mineralization Involved In Bone Maturation Negative Regulation Of Relaxation Of Muscle Regulation Of Aerobic Respiration Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate
Pathways			Nephrin family interactions Striated Muscle Contraction
Drugs
Diseases
GWAS		Copper levels ( 26025379) Cortical volume ( 32963231) Polycystic ovary syndrome ( 22885925)	Bipolar disorder ( 21926972) Frontotemporal dementia with GRN mutation ( 29724592)
Interacting Genes		33 interacting genes: ACTN3 ARK2N AXIN1 CKS1B EDARADD ESRRG FAM118B FAM200A FHL2 FKBP6 GMCL1 HNRNPC KRTAP9-2 L3MBTL3 LCE2A LCE2D MAPK1IP1L NAB2 PHC1 PIAS1 PIAS2 SATB1 SETBP1 SOX5 STX1A SUMO1 TRAF2 TRIM23 UBA2 UBE2I ZBTB26 ZBTB6 ZNRD2	61 interacting genes: ABI3 ACTN1 ACTN2 ACTN4 ADORA2A ASB9 ATP23 BRCA1 C1orf94 CADPS CATSPERT CIMAP1B CIMIP1 CTAG1A CTAG1B CTDSP1 CXCL5 DDAH2 DUX1 DUX4L9 ECM1 FAM90A1 GLIS2 HGS HOXD12 HSF2BP IVD KCTD6 KRT6C LHX3 LINC01554 LNX1 MAGEA6 MICALL2 MYOT MYOZ1 MYPN NDUFAB1 NEBL NKAPD1 NRAP PCCB PKP2 PLEKHG2 POU6F2 PPP1R18 PTK6 REL RNF111 RTP5 SNAI1 SOHLH1 SUMO1P1 SYNPO2L TRAF1 TRAF2 TRIM29 TTN USP2 ZNF343 ZNF426
Entrez ID		391257	89
HPRD ID			02148
Ensembl ID			ENSG00000248746
Uniprot IDs			A0A087WSZ2 B4DZQ2 Q08043
PDB IDs			1TJT 1WKU 3LUE
Enriched GO Terms of Interacting Partners?		Protein Sumoylation Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Identical Protein Binding Small Protein Activating Enzyme Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process PML Body Negative Regulation Of Metabolic Process Protein Modification By Small Protein Conjugation Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Factor Binding SUMO Transferase Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Post-translational Protein Modification Presynaptic Cytosol Postsynaptic Cytosol Transcription Corepressor Activity Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Metabolic Process Regulation Of Gene Expression Ubiquitin Protein Ligase Binding SUMO Ligase Activity Positive Regulation Of Protein Sumoylation Negative Regulation Of Calcineurin-NFAT Signaling Cascade Protein Binding Nucleoplasm Regulation Of Macromolecule Biosynthetic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Nucleus Positive Regulation Of Catabolic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Proteolysis Nuclear Body Negative Regulation Of Calcium-mediated Signaling Chromatin Organization Regulation Of Protein Sumoylation Enzyme Binding Synaptonemal Complex Positive Regulation Of Proteasomal Protein Catabolic Process Chromatin Remodeling Positive Regulation Of Glucose Catabolic Process To Lactate Via Pyruvate	Z Disc Pseudopodium Sarcomere Organization Actin Filament Binding Actin Binding Identical Protein Binding Cytoskeletal Protein Binding Actin Cytoskeleton Organization Actin Filament-based Process Structural Constituent Of Muscle Actinin Binding Muscle Alpha-actinin Binding Protein Binding Cardiac Muscle Thin Filament Assembly Actomyosin Structure Organization Actin Cytoskeleton I Band FATZ Binding Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cytoskeleton Organization Telethonin Binding Stress Fiber Fascia Adherens Supramolecular Fiber Organization Muscle Cell Development Postsynaptic Actin Cytoskeleton Thioesterase Binding
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