BMP1 and PTPRZ1

		BMP1	PTPRZ1
Description		bone morphogenetic protein 1	protein tyrosine phosphatase receptor type Z1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Vesicle	Extracellular Region Plasma Membrane Membrane Extracellular Matrix Synapse Perineuronal Net
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Integrin Binding Protein Binding Hydrolase Activity
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Cartilage Development Positive Regulation Of Cartilage Development	Hematopoietic Progenitor Cell Differentiation Protein Dephosphorylation Signal Transduction Axonogenesis Central Nervous System Development Learning Or Memory Neuron Projection Development Regulation Of Myelination Peptidyl-tyrosine Dephosphorylation Negative Regulation Of Neuron Apoptotic Process Oligodendrocyte Differentiation Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Oligodendrocyte Progenitor Proliferation
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	Other interleukin signaling MDK and PTN in ALK signaling
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778) Hypertriglyceridemia ( 23505323) Myocardial infarction ( 33532862) Waist-to-hip ratio adjusted for BMI ( 28552196)	Hand grip strength ( 27325353) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730)
Interacting Genes		14 interacting genes: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1	13 interacting genes: ADD2 ALK ARHGAP35 CTNNB1 FYN GIT1 HMGB1 IL34 MDK MGAT5B PTN PTPRF TNR
Entrez ID		649	5803
HPRD ID		00209	01481
Ensembl ID		ENSG00000168487	ENSG00000106278
Uniprot IDs		P13497	B4DFE7 P23471
PDB IDs		3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ	3JXF 3S97 5AWX 5H08 8FN8 8FN9
Enriched GO Terms of Interacting Partners?		Basement Membrane Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Region Tissue Development Collagen Trimer Collagen Type V Trimer Negative Regulation Of Endodermal Cell Differentiation Laminin-5 Complex Endodermal Cell Differentiation Collagen Type XI Trimer Epidermis Development Hemidesmosome Assembly Integrin Binding Skin Development Hemidesmosome Collagen Fibril Organization Regulation Of Developmental Process Platelet-derived Growth Factor Binding Collagen Biosynthetic Process Cell Adhesion Protease Binding Response To Xenobiotic Stimulus Microtubule Plus-end Binding Endoplasmic Reticulum Lumen Developmental Process Microtubule Plus-end Negative Regulation Of Developmental Process Animal Organ Development Anatomical Structure Morphogenesis System Development Extracellular Space Negative Regulation Of Cell Differentiation Heparin Binding Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Junction Assembly Cell Cortex Structural Molecule Activity Cell-substrate Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cell Population Proliferation Cellular Response To Vitamin E Skeletal System Development Integrin Biosynthetic Process Collagen Type VII Trimer Regulation Of Myelination	Regulation Of Response To Wounding Cell Migration Regulation Of Oligodendrocyte Differentiation Regulation Of Neuron Projection Development Cell Motility Positive Regulation Of Neuron Projection Development Regulation Of Glial Cell Differentiation Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Developmental Process Positive Regulation Of Oligodendrocyte Differentiation Regulation Of Cellular Component Organization Regulation Of Cell Projection Organization Leukocyte Migration Regulation Of Gliogenesis Schaffer Collateral - CA1 Synapse Positive Regulation Of Leukocyte Chemotaxis Regulation Of Axon Regeneration Regulation Of Neuron Projection Regeneration Neuron Projection Development Negative Regulation Of Multicellular Organismal Process Negative Regulation Of Cell Development Learning Or Memory Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Glial Cell Differentiation Cell Development Nervous System Development Cognition Positive Regulation Of Chemotaxis Positive Regulation Of Leukocyte Migration Growth Factor Activity Heparin Binding Positive Regulation Of Blood Vessel Branching Learning Positive Regulation Of Cell Projection Organization Regulation Of Multicellular Organismal Development Regulation Of Neurogenesis Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Protein Tyrosine Phosphatase Signaling Pathway System Development Regulation Of Blood Vessel Branching Leukocyte Chemotaxis Involved In Inflammatory Response Positive Regulation Of Gliogenesis Positive Regulation Of Epithelial Cell Proliferation Response To Mechanical Stimulus Cell Projection Organization Positive Regulation Of Cellular Component Organization Regulation Of Cell Communication Signal Transduction Regulation Of Signaling Positive Regulation Of Cell Development
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