BMP1 and CST7

Data Source: HiPPIP (Novel)

		BMP1	CST7
Name		bone morphogenetic protein 1	cystatin F
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Golgi Apparatus Vesicle	Extracellular Region Extracellular Space Cytoplasm Lysosome Endosome Late Endosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Cytoplasmic Vesicle
	Molecular Function	Metalloendopeptidase Activity Serine-type Endopeptidase Activity Cytokine Activity Calcium Ion Binding Protein Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Identical Protein Binding Metal Ion Binding	Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Protein Homodimerization Activity
	Biological Process	Skeletal System Development Cartilage Condensation Ossification Proteolysis Signal Transduction Dorsal/ventral Pattern Formation Protein Processing Cell Differentiation Collagen Fibril Organization Cartilage Development Positive Regulation Of Cartilage Development	Regulation Of Antigen Processing And Presentation Immune Response Positive Regulation Of Myelination Negative Regulation Of Microglial Cell Activation Lysosomal Protein Catabolic Process
Pathways		Degradation of the extracellular matrix Degradation of the extracellular matrix Collagen biosynthesis and modifying enzymes Anchoring fibril formation Crosslinking of collagen fibrils	None
GWAS		Coronary artery disease ( 29212778 ) Hypertriglyceridemia ( 23505323 ) Myocardial infarction ( 33532862 ) Waist-to-hip ratio adjusted for BMI ( 28552196 )	Alcohol consumption (drinks per week) ( 30643258 ) Blood protein levels ( 30072576 ) LDL cholesterol levels in HIV infection ( 33109212 )
Novel Interactors		4 novel interactors: CLIP2 CST7 DST PTPRZ1	1 novel interactors: BMP1
Interacting Genes		14 interacting genes: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1	2 interacting genes: CTSB CTSL
Entrez ID		649	8530
HPRD ID		00209	04458
Ensembl ID		ENSG00000168487	ENSG00000077984
Uniprot IDs		P13497	O76096
PDB IDs		3EDG 3EDH 6BSL 6BSM 6BTN 6BTO 6BTP 6BTQ	2CH9
GO Terms Enriched among Interactors		Basement Membrane Extracellular Matrix Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength Fibrillar Collagen Trimer Extracellular Region Tissue Development Collagen Trimer Collagen Type V Trimer Negative Regulation Of Endodermal Cell Differentiation Laminin-5 Complex Endodermal Cell Differentiation Collagen Type XI Trimer Epidermis Development Hemidesmosome Assembly Integrin Binding Skin Development Hemidesmosome Collagen Fibril Organization Regulation Of Developmental Process Platelet-derived Growth Factor Binding Collagen Biosynthetic Process Cell Adhesion Protease Binding Response To Xenobiotic Stimulus Microtubule Plus-end Binding Endoplasmic Reticulum Lumen Developmental Process Microtubule Plus-end Negative Regulation Of Developmental Process Animal Organ Development Anatomical Structure Morphogenesis System Development Extracellular Space Negative Regulation Of Cell Differentiation Heparin Binding Regulation Of Cell Differentiation Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell-substrate Junction Assembly Cell Cortex Structural Molecule Activity Cell-substrate Junction Organization Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Regulation Of Cell Population Proliferation Cellular Response To Vitamin E Skeletal System Development Integrin Biosynthetic Process Collagen Type VII Trimer Regulation Of Myelination	Endolysosome Lumen Proteoglycan Binding Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Peptidase Activity Collagen Catabolic Process Collagen Metabolic Process Cysteine-type Endopeptidase Activity Collagen Binding Symbiont Entry Into Host Cell Cysteine-type Peptidase Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Biological Process Involved In Interaction With Host Protein Processing Proteolysis Hormone Metabolic Process Enkephalin Processing Macrophage Apoptotic Process Elastin Catabolic Process Fusion Of Virus Membrane With Host Plasma Membrane Extracellular Space Peptidase Inhibitor Complex Chromaffin Granule Hydrolase Activity Elastin Metabolic Process Protein Maturation Inflammatory Cell Apoptotic Process Cellular Response To Hormone Stimulus Apical Plasma Membrane Extracellular Matrix Extracellular Region Receptor-mediated Endocytosis Of Virus By Host Cell Lysosome Thyroid Hormone Generation Endocytosis Involved In Viral Entry Into Host Cell Regulation Of Hormone Levels Myeloid Cell Apoptotic Process Endocytic Vesicle Lumen Cell Aggregation Cartilage Condensation Thyroid Hormone Metabolic Process Response To Hormone CD4-positive, Alpha-beta T Cell Lineage Commitment Protein Autoprocessing Alpha-beta T Cell Lineage Commitment Decidualization CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Proteolysis Involved In Protein Catabolic Process Cellular Developmental Process