LAIR1 and CSK

Number of citations of the paper that reports this interaction (PubMedID 16380958)
0

Data Source:
HPRD (two hybrid, in vivo)

		LAIR1	CSK
Description		leukocyte associated immunoglobulin like receptor 1	C-terminal Src kinase
Image
GO Annotations	Cellular Component	Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Membrane Extracellular Exosome
	Molecular Function	Protein Binding	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Phosphatase Binding Protein Kinase A Catalytic Subunit Binding Identical Protein Binding Metal Ion Binding Proline-rich Region Binding Protein Tyrosine Kinase Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response-regulating Signaling Pathway	Adaptive Immune Response Immune System Process Regulation Of Immune System Process Protein Phosphorylation Negative Regulation Of Cell Population Proliferation Negative Regulation Of Low-density Lipoprotein Particle Clearance T Cell Costimulation Negative Regulation Of Interleukin-6 Production Adherens Junction Organization Intracellular Signal Transduction Negative Regulation Of Golgi To Plasma Membrane Protein Transport Negative Regulation Of Bone Resorption Oligodendrocyte Differentiation Negative Regulation Of Phagocytosis T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of T Cell Activation Regulation Of Multicellular Organismal Process Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Peptide Hormone Stimulus
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains Integrin signaling Co-inhibition by PD-1 MAP2K and MAPK activation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF RHOH GTPase cycle Signaling downstream of RAS mutants Signaling by RAF1 mutants Negative regulation of FLT3
Drugs			Dasatinib Staurosporine TG-100801 Fostamatinib
Diseases
GWAS			Blood pressure ( 21909110) Blood protein levels ( 30072576) Body mass index and systole blood pressure (pairwise) ( 33619380) Caffeine consumption ( 21490707) Coffee consumption ( 31959922) Diastolic blood pressure ( 19430483 26390057 19430479) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Hypertension ( 31513605) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (diuretics) ( 31015401) Myocardial infarction ( 33532862) Offspring birth weight ( 31043758) Serum albumin levels ( 29403010) Systemic lupus erythematosus ( 27399966 33272962 26502338 28714469) Systemic lupus erythematosus and Systemic sclerosis ( 23740937) Systemic sclerosis ( 31672989) Systolic blood pressure ( 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962)
Interacting Genes		5 interacting genes: APP COL1A1 CSK PTPN11 PTPN6	51 interacting genes: ADRB2 ARRB1 CAV1 CD247 CD3E CD44 CDC45 CDH5 CREBBP DAB2 DOK1 DOK2 DOK3 FGR FHL2 FYN G3BP1 GJA1 GSN HCK HNRNPK ID3 IGF1R INSR KANK4 KHDRBS1 LAIR1 LCK LYN MAPK15 PAG1 PDPK1 PECAM1 PLD2 PRKACA PTK2 PTPN12 PTPN18 PTPN22 PXN RASA1 RGS16 SDC3 SHC1 SIT1 SRC TGFB1I1 TLR3 UBE2I ZAP70 ZNF212
Entrez ID		3903	1445
HPRD ID		04292	00496
Ensembl ID		ENSG00000167613	ENSG00000103653
Uniprot IDs		A0A0G2JMI0 A0A0G2JNK8 A0A140T8W3 A8MZ84 D3YTC8 Q6GTX8	A8K3B6 B2R6Q4 P41240
PDB IDs		3KGR 3RP1 7F9L 7F9M 7F9N	1BYG 1CSK 3D7T 3D7U 3EAC 3EAZ
Enriched GO Terms of Interacting Partners?		Face Morphogenesis T Cell Costimulation Negative Regulation Of Neutrophil Activation Myeloid Cell Development Regulation Of Immune Response Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Regulation Of ERK1 And ERK2 Cascade Protein Tyrosine Phosphatase Activity Negative Regulation Of Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Myeloid Leukocyte Activation Negative Regulation Of T Cell Activation Peptidyl-tyrosine Dephosphorylation Phosphoprotein Phosphatase Activity Platelet Formation Dephosphorylation Megakaryocyte Development Positive Regulation Of Cell Activation Regulation Of Interleukin-6 Production Immune Response-regulating Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Cell Activation Involved In Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Lymphocyte Activation Hemopoiesis Response To Mechanical Stimulus Sarcomere Organization Cell-cell Junction Protein Tyrosine Kinase Binding Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune System Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Leukocyte Activation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Vitamin E	Cell Surface Receptor Signaling Pathway Signal Transduction Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Immune Response-activating Signaling Pathway Regulation Of Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Peptidyl-tyrosine Phosphorylation Activation Of Immune Response Fc Receptor Signaling Pathway Focal Adhesion Positive Regulation Of Signal Transduction Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Regulation Of Signaling Regulation Of Cell Communication Fc Receptor Mediated Stimulatory Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Positive Regulation Of Cell Communication Positive Regulation Of Signaling Regulation Of Intracellular Signal Transduction Protein Autophosphorylation Protein Tyrosine Kinase Activity Intracellular Signal Transduction Protein Phosphorylation Immune System Process Regulation Of Apoptotic Process Positive Regulation Of MAPK Cascade Regulation Of MAPK Cascade T Cell Costimulation Positive Regulation Of Immune Response Regulation Of Programmed Cell Death Phosphorylation Anchoring Junction Regulation Of Immune Response Positive Regulation Of Immune System Process Membrane Raft Positive Regulation Of Multicellular Organismal Process Plasma Membrane SH2 Domain Binding Regulation Of Immune System Process Protein Kinase Activity Positive Regulation Of Cellular Component Organization Intracellular Signaling Cassette Signal Complex Assembly Phosphotyrosine Residue Binding Negative Regulation Of Cell Communication
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?