LAIR1 and KIR3DS1

Data Source: HiPPIP (Novel)

		LAIR1	KIR3DS1
Name		leukocyte associated immunoglobulin like receptor 1	killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding	Protein Binding MHC Class I Receptor Activity
	Biological Process	Adaptive Immune Response Immune System Process Immune Response-regulating Signaling Pathway	Immune Response-regulating Signaling Pathway Immune Response Natural Killer Cell Activation
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	DAP12 interactions
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		8 novel interactors: CENPB CFL2 CNOT3 KIR3DS1 LAIR2 MYH3 PRKCG PTPRH	2 novel interactors: KIR3DL1 LAIR1
Interacting Genes		5 interacting genes: APP COL1A1 CSK PTPN11 PTPN6	2 interacting genes: HLA-B TYROBP
Entrez ID		3903	3813
HPRD ID		04292	10034
Ensembl ID		ENSG00000167613	Not available
Uniprot IDs		A0A0G2JMI0 A0A0G2JNK8 A0A140T8W3 A8MZ84 D3YTC8 Q6GTX8	A0A0G2JN05 O43469 Q14943 Q4KN23 Q99565
PDB IDs		3KGR 3RP1 7F9L 7F9M 7F9N	Not available
GO Terms Enriched among Interactors		Face Morphogenesis T Cell Costimulation Negative Regulation Of Neutrophil Activation Myeloid Cell Development Regulation Of Immune Response Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Regulation Of ERK1 And ERK2 Cascade Protein Tyrosine Phosphatase Activity Negative Regulation Of Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Myeloid Leukocyte Activation Negative Regulation Of T Cell Activation Peptidyl-tyrosine Dephosphorylation Phosphoprotein Phosphatase Activity Platelet Formation Dephosphorylation Megakaryocyte Development Positive Regulation Of Cell Activation Regulation Of Interleukin-6 Production Immune Response-regulating Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Cell Activation Involved In Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Lymphocyte Activation Hemopoiesis Response To Mechanical Stimulus Sarcomere Organization Cell-cell Junction Protein Tyrosine Kinase Binding Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune System Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Leukocyte Activation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Vitamin E	Regulation Of Immune Response Immune Response Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Immune System Process Positive Regulation Of Cell Killing Immune Response-regulating Signaling Pathway Immune System Process Innate Immune Response Secretory Granule Membrane Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity Defense Response To Other Organism Defense Response To Symbiont Regulation Of Interleukin-6 Production HLA-B Specific Inhibitory MHC Class I Receptor Activity Leukocyte Mediated Immunity Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway TAP Binding Molecular Adaptor Activity Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Macrophage Fusion Response To Other Organism Microglial Cell Activation Involved In Immune Response Positive Regulation Of Immune Effector Process Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Transforming Growth Factor Beta1 Production Defense Response Response To External Biotic Stimulus Adaptive Immune Response Regulation Of T Cell Anergy T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell MHC Class I Protein Complex Regulation Of Osteoclast Development Detection Of Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of T Cell Tolerance Induction Immune Effector Process Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Transforming Growth Factor Beta Production Signaling Receptor Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Regulation Of Hemopoiesis Regulation Of Dendritic Cell Differentiation Regulation Of Innate Immune Response Negative Regulation Of B Cell Proliferation Regulation Of Tolerance Induction