LAIR1 and CFL2

Data Source: HiPPIP (Novel)

		LAIR1	CFL2
Name		leukocyte associated immunoglobulin like receptor 1	cofilin 2
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane	Extracellular Space Nucleus Cytoplasm Cytoskeleton Actin Cytoskeleton Nuclear Matrix Z Disc I Band Extracellular Exosome
	Molecular Function	Protein Binding	Actin Binding Protein Binding Actin Filament Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response-regulating Signaling Pathway	Actin Filament Organization Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Actin Filament Depolymerization Actin Filament Fragmentation Positive Regulation Of Actin Filament Depolymerization Sarcomere Organization Muscle Cell Cellular Homeostasis Actin Filament Severing
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	None
Diseases		None	Nemaline myopathy
GWAS		No GWAS studies recorded	Alanine aminotransferase levels ( 33547301 34315874 ) Aspartate aminotransferase levels ( 33547301 34315874 ) Atrial fibrillation ( 29892015 30061737 ) Hip circumference adjusted for BMI ( 28552196 ) Liver enzyme levels (alanine transaminase) ( 33972514 ) Takayasu arteritis ( 33308445 )
Novel Interactors		8 novel interactors: CENPB CFL2 CNOT3 KIR3DS1 LAIR2 MYH3 PRKCG PTPRH	2 novel interactors: LAIR1 ZYG11B
Interacting Genes		5 interacting genes: APP COL1A1 CSK PTPN11 PTPN6	12 interacting genes: ACTB ACTG1 CAP2 LIMK1 PDE4B POT1 RAB2A RNF4 SSH1 STK11 TRIM7 UBE2I
Entrez ID		3903	1073
HPRD ID		04292	03262
Ensembl ID		ENSG00000167613	ENSG00000165410
Uniprot IDs		A0A0G2JMI0 A0A0G2JNK8 A0A140T8W3 A8MZ84 D3YTC8 Q6GTX8	Q549N0 Q9Y281
PDB IDs		3KGR 3RP1 7F9L 7F9M 7F9N	7M0G 7U8K
GO Terms Enriched among Interactors		Face Morphogenesis T Cell Costimulation Negative Regulation Of Neutrophil Activation Myeloid Cell Development Regulation Of Immune Response Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Regulation Of ERK1 And ERK2 Cascade Protein Tyrosine Phosphatase Activity Negative Regulation Of Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Myeloid Leukocyte Activation Negative Regulation Of T Cell Activation Peptidyl-tyrosine Dephosphorylation Phosphoprotein Phosphatase Activity Platelet Formation Dephosphorylation Megakaryocyte Development Positive Regulation Of Cell Activation Regulation Of Interleukin-6 Production Immune Response-regulating Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Cell Activation Involved In Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Lymphocyte Activation Hemopoiesis Response To Mechanical Stimulus Sarcomere Organization Cell-cell Junction Protein Tyrosine Kinase Binding Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune System Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Leukocyte Activation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Vitamin E	Structural Constituent Of Postsynaptic Actin Cytoskeleton Actin Filament-based Process Regulation Of Transepithelial Transport Actin Cytoskeleton Organization Dense Body Morphogenesis Of A Polarized Epithelium Schaffer Collateral - CA1 Synapse Postsynaptic Actin Cytoskeleton Organization Protein Localization To Cell-cell Junction Calyx Of Held Postsynaptic Cytoskeleton Organization Apical Junction Complex NuA4 Histone Acetyltransferase Complex Axonogenesis Regulation Of Synaptic Vesicle Endocytosis Regulation Of Organelle Organization Regulation Of Synaptic Vesicle Recycling Establishment Or Maintenance Of Cell Polarity Regulation Of Actin Filament-based Process Immune Response-regulating Signaling Pathway Maintenance Of Blood-brain Barrier Anatomical Structure Homeostasis Tissue Homeostasis Lamellipodium Multicellular Organismal-level Homeostasis Cytoplasm Cytoskeleton Organization Platelet Aggregation Positive Regulation Of Norepinephrine Uptake Cellular Response To Cytochalasin B Basal Body Patch Regulation Of Cytoskeleton Organization SUMO Conjugating Enzyme Activity Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Regulation Of Chromosome Organization Immune Response-activating Cell Surface Receptor Signaling Pathway Protein Modification Process Neuron Projection Morphogenesis Homotypic Cell-cell Adhesion Regulation Of Actin Filament Organization Cell Projection Morphogenesis Immune Response-regulating Cell Surface Receptor Signaling Pathway Nucleotide Binding Regulation Of Norepinephrine Uptake Negative Regulation Of Relaxation Of Cardiac Muscle Positive Regulation Of Telomeric Loop Disassembly Positive Regulation Of AMPA Glutamate Receptor Clustering Regulation Of Cellular Component Organization