LAIR1 and LAIR2

Data Source: HiPPIP (Novel)

		LAIR1	LAIR2
Name		leukocyte associated immunoglobulin like receptor 1	leukocyte associated immunoglobulin like receptor 2
Structure			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane	Extracellular Region Plasma Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response-regulating Signaling Pathway	Immune Response-regulating Signaling Pathway
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
GWAS		No GWAS studies recorded	Neurological blood protein biomarker levels ( 31320639 )
Interacting Genes		5 interacting genes: APP COL1A1 CSK PTPN11 PTPN6	5 interacting genes: EMILIN1 LCN2 SGTA UBQLN1 UBQLN2
Entrez ID		3903	3904
HPRD ID		04292	04293
Ensembl ID		ENSG00000167613	ENSG00000167618
Uniprot IDs		A0A0G2JMI0 A0A0G2JNK8 A0A140T8W3 A8MZ84 D3YTC8 Q6GTX8	Q6ISS4
PDB IDs		3KGR 3RP1 7F9L 7F9M 7F9N	Not available
GO Terms Enriched among Interactors		Face Morphogenesis T Cell Costimulation Negative Regulation Of Neutrophil Activation Myeloid Cell Development Regulation Of Immune Response Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Regulation Of ERK1 And ERK2 Cascade Protein Tyrosine Phosphatase Activity Negative Regulation Of Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Myeloid Leukocyte Activation Negative Regulation Of T Cell Activation Peptidyl-tyrosine Dephosphorylation Phosphoprotein Phosphatase Activity Platelet Formation Dephosphorylation Megakaryocyte Development Positive Regulation Of Cell Activation Regulation Of Interleukin-6 Production Immune Response-regulating Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Cell Activation Involved In Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Lymphocyte Activation Hemopoiesis Response To Mechanical Stimulus Sarcomere Organization Cell-cell Junction Protein Tyrosine Kinase Binding Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune System Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Leukocyte Activation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Vitamin E	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Endoplasmic Reticulum Stress Identical Protein Binding Polyubiquitin Modification-dependent Protein Binding Regulation Of Protein Catabolic Process Regulation Of Proteolysis Positive Regulation Of Hippocampal Neuron Apoptotic Process Autophagosome Negative Regulation Of Store-operated Calcium Channel Activity Proteasomal Protein Catabolic Process Positive Regulation Of Iron Ion Import Across Plasma Membrane Enterobactin Binding Positive Regulation Of Endothelial Tube Morphogenesis Iron Ion Sequestering Activity Regulation Of Cellular Response To Stress TRC Complex Positive Regulation Of Catabolic Process EMILIN Complex Autophagosome Organization Autophagosome Assembly Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Decreased Oxygen Levels Siderophore Transport Cellular Response To Hypoxia Cellular Response To Stress Protein Catabolic Process Integrin Alpha4-beta1 Complex Negative Regulation Of Collagen Fibril Organization Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Proteolysis Involved In Protein Catabolic Process Cellular Response To Oxygen Levels Cytoplasmic Vesicle Lumen Negative Regulation Of Hippocampal Neuron Apoptotic Process Response To Kainic Acid BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Vacuole Organization Response To Herbicide Positive Regulation Of Metabolic Process Regulation Of Hippocampal Neuron Apoptotic Process