LAIR1 and PTPRH

Data Source: HiPPIP (Novel)

		LAIR1	PTPRH
Name		leukocyte associated immunoglobulin like receptor 1	protein tyrosine phosphatase receptor type H
Structure
GO Annotations	Cellular Component	Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane	Cytoplasm Cytosol Plasma Membrane Microvillus Membrane Apical Plasma Membrane Nuclear Speck Microvillus Membrane Cell Projection
	Molecular Function	Protein Binding	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Hydrolase Activity Cadherin Binding
	Biological Process	Adaptive Immune Response Immune System Process Immune Response-regulating Signaling Pathway	Protein Dephosphorylation Apoptotic Process Signal Transduction Axon Guidance
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Neutrophil degranulation	None
GWAS		No GWAS studies recorded	Mean spheric corpuscular volume ( 32888494 ) Monocyte percentage of white cells ( 32888494 ) Platelet count ( 32888494 ) Platelet distribution width ( 32888494 ) Plateletcrit ( 27863252 32888494 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Serum metabolite levels ( 33031748 ) Systemic lupus erythematosus ( 28714469 )
Novel Interactors		8 novel interactors: CENPB CFL2 CNOT3 KIR3DS1 LAIR2 MYH3 PRKCG PTPRH	1 novel interactors: LAIR1
Interacting Genes		5 interacting genes: APP COL1A1 CSK PTPN11 PTPN6	16 interacting genes: BCAR1 CNKSR1 CRK DHPS DOK1 EGFR ERBB3 ERBB4 GHR KRTAP10-3 KRTAP10-8 LCK MAPK1 MLH1 PTK2 PXN
Entrez ID		3903	5794
HPRD ID		04292	03942
Ensembl ID		ENSG00000167613	ENSG00000080031
Uniprot IDs		A0A0G2JMI0 A0A0G2JNK8 A0A140T8W3 A8MZ84 D3YTC8 Q6GTX8	Q9HD43
PDB IDs		3KGR 3RP1 7F9L 7F9M 7F9N	7XC0
GO Terms Enriched among Interactors		Face Morphogenesis T Cell Costimulation Negative Regulation Of Neutrophil Activation Myeloid Cell Development Regulation Of Immune Response Non-membrane Spanning Protein Tyrosine Phosphatase Activity Protein Dephosphorylation Regulation Of Neutrophil Activation Neutrophil Activation Involved In Immune Response Regulation Of ERK1 And ERK2 Cascade Protein Tyrosine Phosphatase Activity Negative Regulation Of Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Activity Insulin Receptor Binding Myeloid Leukocyte Activation Negative Regulation Of T Cell Activation Peptidyl-tyrosine Dephosphorylation Phosphoprotein Phosphatase Activity Platelet Formation Dephosphorylation Megakaryocyte Development Positive Regulation Of Cell Activation Regulation Of Interleukin-6 Production Immune Response-regulating Signaling Pathway Negative Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Lipopolysaccharide-mediated Signaling Pathway Neutrophil Activation Cell Activation Involved In Immune Response Negative Regulation Of T Cell Receptor Signaling Pathway Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Lymphocyte Activation Hemopoiesis Response To Mechanical Stimulus Sarcomere Organization Cell-cell Junction Protein Tyrosine Kinase Binding Negative Regulation Of Leukocyte Activation Negative Regulation Of Cell-cell Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Type I Interferon-mediated Signaling Pathway Negative Regulation Of Protein Localization Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Immune System Process Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Leukocyte Activation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Vitamin E	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Enzyme-linked Receptor Protein Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway ERBB2 Signaling Pathway Cell Surface Receptor Signaling Pathway Protein Phosphatase Binding SH2 Domain Binding Protein Tyrosine Kinase Activity Protein Tyrosine Kinase Activator Activity Signal Transduction Regulation Of MAPK Cascade Growth Hormone Receptor Signaling Pathway Epidermal Growth Factor Receptor Activity Neuregulin Receptor Activity Positive Regulation Of MAPK Cascade Protein Kinase Activity Positive Regulation Of Macrophage Proliferation Response To Growth Factor Phosphotyrosine Residue Binding Cell Migration Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Kinase Activity Response To Epidermal Growth Factor B Cell Receptor Signaling Pathway Signal Complex Assembly ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway Cell Motility Receptor Complex Basal Plasma Membrane Immune Response-regulating Signaling Pathway Focal Adhesion Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Immune System Process Positive Regulation Of Protein Phosphorylation Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Growth Positive Regulation Of Phosphorylation Response To Hepatocyte Growth Factor Cellular Response To Growth Factor Stimulus Positive Regulation Of Cell Communication Positive Regulation Of Signaling Immune Response-regulating Cell Surface Receptor Signaling Pathway Schwann Cell Development Positive Regulation Of Cell Migration T Cell Receptor Signaling Pathway