LAG3 and KCNA1

Data Source: HiPPIP (Novel)

		LAG3	KCNA1
Name		lymphocyte activating 3	potassium voltage-gated channel subfamily A member 1
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Cell Junction Axon Dendrite Cytoplasmic Vesicle Paranode Region Of Axon Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Axon Initial Segment Perikaryon Axon Terminus Juxtaparanode Region Of Axon Synapse Anchoring Junction Presynapse
	Molecular Function	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding MHC Class II Protein Binding	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Disordered Domain Specific Binding
	Biological Process	Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production T Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Activation	Action Potential Startle Response Monoatomic Ion Transport Potassium Ion Transport Regulation Of Muscle Contraction Neuroblast Proliferation Brain Development Cell Communication By Electrical Coupling Magnesium Ion Homeostasis Neuronal Action Potential Hippocampus Development Neuronal Signal Transduction Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Neuromuscular Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Homooligomerization Transmembrane Transport Cellular Response To Magnesium Ion Potassium Ion Transmembrane Transport Membrane Repolarization During Action Potential
Pathways		MHC class II antigen presentation	Voltage gated Potassium channels
Drugs		Relatlimab	Enflurane Amitriptyline Isoflurane Methoxyflurane Promethazine Miconazole Desflurane Dalfampridine Tetraethylammonium Amifampridine
Diseases		None	Episodic ataxias
GWAS		Blood protein levels ( 30072576 )	No GWAS studies recorded
Interacting Genes		2 interacting genes: CEBPZ CPAP	17 interacting genes: APOL2 DLG1 DLG4 DOLK FCER1G GPR152 GPR42 IER3IP1 JAGN1 KCNA10 KCNA2 KCNA3 KCNE4 MAL SGTA TMEM14B TMEM86A
Entrez ID		3902	3736
HPRD ID		01077	08885
Ensembl ID		ENSG00000089692	ENSG00000111262
Uniprot IDs		P18627	Q09470
PDB IDs		7TZG 7TZH 7UM3 8SO3 8SR0 9BF9	Not available
GO Terms Enriched among Interactors		None	Delayed Rectifier Potassium Channel Activity Membrane Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Activity Regulation Of Membrane Potential Action Potential Endoplasmic Reticulum Membrane Monoatomic Ion Channel Complex Endoplasmic Reticulum Localization Within Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Protein Insertion Into Membrane Juxtaparanode Region Of Axon Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Across Plasma Membrane Insulin Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization Membrane Raft Organization Ionotropic Glutamate Receptor Binding Protein Insertion Into ER Membrane Leukocyte Mediated Immunity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Monoatomic Ion Channel Activity Cellular Localization P2Y1 Nucleotide Receptor Binding IgE Receptor Activity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Dolichol Kinase Activity Potassium Channel Regulator Activity Protein Homooligomerization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Establishment Of Protein Localization To Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Cell Periphery Protein Localization To Synapse Establishment Of Protein Localization Positive Regulation Of Type I Hypersensitivity Fc-epsilon Receptor I Complex Export Across Plasma Membrane Optic Nerve Structural Organization