KCNA1 and DLG1

Number of citations of the paper that reports this interaction (PMID 7477295)
165

Data Source:
HPRD (two hybrid)

		KCNA1	DLG1
Gene Name		potassium channel, voltage gated shaker related subfamily A, member 1	discs, large homolog 1 (Drosophila)
Image
Gene Ontology Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Integral Component Of Membrane Apical Plasma Membrane Cell Junction Dendrite Paranode Region Of Axon Presynaptic Membrane Neuronal Cell Body Axon Terminus Juxtaparanode Region Of Axon Synapse	Immunological Synapse Basal Lamina Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Microtubule Plasma Membrane Cell-cell Junction Tight Junction Ionotropic Glutamate Receptor Complex Cytoplasmic Side Of Plasma Membrane Postsynaptic Density Intercalated Disc Basolateral Plasma Membrane Lateral Plasma Membrane Cell Junction Cell Projection Membrane Neuromuscular Junction Node Of Ranvier Myelin Sheath Abaxonal Region Sarcolemma Lateral Loop Membrane Raft Postsynaptic Membrane Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome MPP7-DLG1-LIN7 Complex
	Molecular Function	Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Potassium Ion Transmembrane Transporter Activity	Guanylate Kinase Activity Phosphoprotein Phosphatase Activity Protein Binding Protein C-terminus Binding Cytoskeletal Protein Binding Potassium Channel Regulator Activity Protein Kinase Binding Phosphatase Binding Mitogen-activated Protein Kinase Kinase Binding Protein Complex Scaffold Ionotropic Glutamate Receptor Binding Ion Channel Binding L27 Domain Binding
	Biological Process	Potassium Ion Transport Regulation Of Muscle Contraction Synaptic Transmission Cell Communication By Electrical Coupling Magnesium Ion Homeostasis Neuronal Action Potential Neuronal Signal Transduction Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Neuromuscular Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Homooligomerization Cellular Response To Magnesium Ion Potassium Ion Transmembrane Transport	Branching Involved In Ureteric Bud Morphogenesis Immunological Synapse Formation Endothelial Cell Proliferation Lens Development In Camera-type Eye T Cell Cytokine Production Actin Filament Organization Mitotic Cell Cycle Checkpoint Establishment Or Maintenance Of Cell Polarity Synaptic Transmission Nervous System Development Axon Guidance Positive Regulation Of Cell Proliferation Viral Process Dephosphorylation Single Organismal Cell-cell Adhesion Peristalsis Positive Regulation Of Actin Filament Polymerization Cortical Actin Cytoskeleton Organization Membrane Raft Organization Regulation Of Myelination Activation Of Protein Kinase Activity T Cell Activation Negative Regulation Of T Cell Proliferation Regulation Of Membrane Potential Amyloid Precursor Protein Metabolic Process Receptor Clustering Positive Regulation Of Potassium Ion Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Negative Regulation Of Mitotic Cell Cycle Nucleotide Phosphorylation Reproductive Structure Development Embryonic Skeletal System Morphogenesis Smooth Muscle Tissue Development Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Protein Kinase B Signaling Hard Palate Development Tight Junction Assembly Protein Localization To Plasma Membrane Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Receptor Localization To Synapse Regulation Of Sodium Ion Transmembrane Transport
Pathways		Potassium Channels Voltage gated Potassium channels	Axon guidance Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity L1CAM interactions NrCAM interactions Activation of Kainate Receptors upon glutamate binding Activation of Ca-permeable Kainate Receptor Trafficking of AMPA receptors Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Ionotropic activity of Kainate Receptors Transmission across Chemical Synapses
Drugs		Enflurane Amitriptyline Isoflurane Methoxyflurane Nifedipine Desflurane Sevoflurane Dalfampridine
Diseases
GWAS
Protein-Protein Interactions		3 interactors: DLG1 DLG4 KCNE4	72 interactors: ACTA1 ACTN2 ADAM17 ADRB1 AKAP5 ATP2B2 ATP2B4 BAI1 BCR BEGAIN CACNG2 CALM2 CAMK2A CASK CNKSR2 CRIPT CTNNA1 DLG2 DLG3 DLGAP1 DLGAP3 DLGAP4 EPB41 ERBB4 EZR FZD4 FZD7 GDA GLS2 GNG13 GPR124 GPR125 GRIA1 GRIK2 GRIN2A GRIN2B GUCY1A2 KCNA1 KCNA2 KCNA3 KCNA4 KCNA5 KCNAB1 KCNJ10 KCNJ12 KCNJ2 KCNJ4 KCNJ6 KHDRBS1 KIF13B KIF1B LCK LRP2 LRRC1 MAP1A MAPK12 MPP2 MRPS34 MYO6 PARK2 PAX6 PBK PTEN SCN4A SCN5A SEMA4C STX4 TANC1 TJAP1 UBE3A WAS WNT3A
Entrez ID		3736	1739
HPRD ID		08885	03007
Ensembl ID		ENSG00000111262	ENSG00000075711
Uniprot IDs		Q09470	B4DF78 Q12959
PDB IDs		2AFL	1PDR 2M3M 2OQS 2X7Z 3LRA 3RL7 3RL8 3W9Y 4AMH 4G69
Enriched GO Terms of Interacting Partners?		Receptor Localization To Synapse Protein Localization To Synapse Cortical Actin Cytoskeleton Organization Establishment Or Maintenance Of Apical/basal Cell Polarity Cortical Cytoskeleton Organization Regulation Of Ion Transmembrane Transport Receptor Clustering Nucleotide Phosphorylation Regulation Of Ion Transport Establishment Or Maintenance Of Cell Polarity Regulation Of Membrane Potential T Cell Cytokine Production Hard Palate Development Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Clustering Regulation Of Grooming Behavior Protein Localization To Membrane Maintenance Of Apical/basal Cell Polarity Axon Guidance Negative Regulation Of Receptor Internalization Peristalsis Cytokine Production Involved In Immune Response Immunological Synapse Formation Locomotory Exploration Behavior Dendritic Spine Morphogenesis Synaptic Vesicle Maturation Maintenance Of Cell Polarity Axonogenesis Nucleotide Metabolic Process Axon Development Vocalization Behavior Cell Morphogenesis Involved In Neuron Differentiation Synaptic Transmission Amyloid Precursor Protein Metabolic Process Chemotaxis Actin Cytoskeleton Organization Membrane Raft Organization Dendritic Spine Development Neuron Projection Morphogenesis Endothelial Cell Proliferation Actin Filament-based Process Nucleobase-containing Small Molecule Metabolic Process Negative Regulation Of Receptor-mediated Endocytosis Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Dendritic Spine Organization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Establishment Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane Exploration Behavior Postsynaptic Membrane Organization	Synaptic Transmission Cell-cell Signaling Signaling Cell Communication Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Metal Ion Transport Regulation Of Membrane Potential Neurological System Process Regulation Of Signaling Cation Transport Ion Transport Potassium Ion Transmembrane Transport Potassium Ion Transport Regulation Of Synaptic Plasticity Nervous System Development Response To Wounding Cation Transmembrane Transport Transport Ion Transmembrane Transport Regulation Of Cellular Localization Regulation Of Phosphorus Metabolic Process Neuron-neuron Synaptic Transmission Regulation Of Synaptic Transmission Response To Abiotic Stimulus Membrane Depolarization Regulation Of Cellular Process Regulation Of Signal Transduction Action Potential Monovalent Inorganic Cation Transport Response To Stimulus Potassium Ion Import System Development Transmembrane Transport Behavior Cellular Process Transmission Of Nerve Impulse Wound Healing Cellular Response To Stimulus Neuronal Action Potential Positive Regulation Of Transport Regulation Of Heart Contraction Cellular Localization Anatomical Structure Development Membrane Hyperpolarization Protein Homooligomerization Regulation Of Cellular Component Movement Regulation Of Body Fluid Levels Central Nervous System Development Neuromuscular Process
Tagcloud ?		channel classes custom excitability gated genotyping gmm haplotype intriguing inwardly kcnd2 kcnj3 kcnj6 kcnk9 latent member membership mild monthly pain persistent postsurgical potassium rectifying snps subfamily variations voltage warrant	adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly
Tagcloud (Difference) ?		channel classes custom excitability gated genotyping gmm haplotype intriguing inwardly kcnd2 kcnj3 kcnj6 kcnk9 latent member membership mild monthly pain persistent postsurgical potassium rectifying snps subfamily variations voltage warrant	adjust axonal b3 conditional ddit4 dephosphorylates dephosphorylation hypermyelination modulator mtorc1 myelin myelination nerves neuregulin pip3 pns precedes provokes ptdins pten redd1 rtp801 sap97 scaffolding schwann sustained tensin thickness tightly
Tagcloud (Intersection) ?