KCNA1 and TMEM86A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNA1	TMEM86A
Description		potassium voltage-gated channel subfamily A member 1	transmembrane protein 86A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Cell Junction Axon Dendrite Cytoplasmic Vesicle Paranode Region Of Axon Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Axon Initial Segment Perikaryon Axon Terminus Juxtaparanode Region Of Axon Synapse Anchoring Junction Presynapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Disordered Domain Specific Binding	Protein Binding Hydrolase Activity Alkenylglycerophosphocholine Hydrolase Activity
	Biological Process	Action Potential Startle Response Monoatomic Ion Transport Potassium Ion Transport Regulation Of Muscle Contraction Neuroblast Proliferation Brain Development Cell Communication By Electrical Coupling Magnesium Ion Homeostasis Neuronal Action Potential Hippocampus Development Neuronal Signal Transduction Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Neuromuscular Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Homooligomerization Transmembrane Transport Cellular Response To Magnesium Ion Potassium Ion Transmembrane Transport Membrane Repolarization During Action Potential	Lipid Metabolic Process
Pathways		Voltage gated Potassium channels
Drugs		Enflurane Amitriptyline Isoflurane Methoxyflurane Promethazine Miconazole Desflurane Dalfampridine Tetraethylammonium Amifampridine
Diseases		Episodic ataxias
GWAS			Ovarian reserve ( 22116950)
Interacting Genes		17 interacting genes: APOL2 DLG1 DLG4 DOLK FCER1G GPR152 GPR42 IER3IP1 JAGN1 KCNA10 KCNA2 KCNA3 KCNE4 MAL SGTA TMEM14B TMEM86A	48 interacting genes: AQP2 AQP3 BCL2L13 CD79A CISD2 CNR2 COQ9 CPLX4 CREB3L1 EBP ERGIC3 FAM209A FFAR2 FKBP7 FNDC9 FXYD3 GJB4 GJB5 GJC1 GORAB GPR37L1 GPX8 HAVCR2 KASH5 KCNA1 LHFPL5 LMNA MS4A2 MUC1 NCAPH2 PDZK1IP1 PGRMC2 PI16 REEP4 RIC3 RNF185 SCN3B SLC10A6 SLC18A1 SLC30A2 SLC35H1 SLC39A2 SSMEM1 THAP4 TIMMDC1 TMEM31 TMPRSS2 TYROBP
Entrez ID		3736	144110
HPRD ID		08885	08292
Ensembl ID		ENSG00000111262	ENSG00000151117
Uniprot IDs		Q09470	Q8N2M4
PDB IDs
Enriched GO Terms of Interacting Partners?		Delayed Rectifier Potassium Channel Activity Membrane Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Activity Regulation Of Membrane Potential Action Potential Endoplasmic Reticulum Membrane Monoatomic Ion Channel Complex Endoplasmic Reticulum Localization Within Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Protein Insertion Into Membrane Juxtaparanode Region Of Axon Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Across Plasma Membrane Insulin Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization Membrane Raft Organization Ionotropic Glutamate Receptor Binding Protein Insertion Into ER Membrane Leukocyte Mediated Immunity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Monoatomic Ion Channel Activity Cellular Localization P2Y1 Nucleotide Receptor Binding IgE Receptor Activity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Dolichol Kinase Activity Potassium Channel Regulator Activity Protein Homooligomerization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Establishment Of Protein Localization To Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Cell Periphery Protein Localization To Synapse Establishment Of Protein Localization Positive Regulation Of Type I Hypersensitivity Fc-epsilon Receptor I Complex Export Across Plasma Membrane Optic Nerve Structural Organization	Membrane Transmembrane Transport Protein Binding Connexin Complex Gap Junction Channel Activity Gap Junction Glycerol Transmembrane Transport Monoatomic Ion Transport Renal Water Transport Endoplasmic Reticulum Polyol Transmembrane Transport Atrial Cardiac Muscle Cell Action Potential Transport Vesicle Membrane
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