LAG3 and CPAP

Number of citations: 0 (PubMedID 11592063)
Data Source: HPRD (two hybrid, in vitro, in vivo)

		LAG3	CPAP
Name		lymphocyte activating 3	centrosome assembly and centriole elongation protein
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Microtubule Gamma-tubulin Small Complex Ciliary Basal Body Procentriole Replication Complex
	Molecular Function	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding MHC Class II Protein Binding	Transcription Coactivator Activity Protein Binding Tubulin Binding Protein Kinase Binding Protein Domain Specific Binding Identical Protein Binding Gamma-tubulin Binding
	Biological Process	Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production T Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Activation	Microtubule Nucleation Centriole Replication Smoothened Signaling Pathway Astral Microtubule Nucleation Motile Cilium Assembly Positive Regulation Of DNA-templated Transcription Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Regulation Of Centriole Replication Positive Regulation Of Centriole Replication Microtubule Polymerization Centrosome Duplication Cell Division Regulation Of Mitotic Spindle Organization Cilium Assembly Centriole Elongation Centriole Assembly Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Organelle Assembly Positive Regulation Of Non-motile Cilium Assembly Positive Regulation Of Centriole Elongation Positive Regulation Of Establishment Of Protein Localization Non-motile Cilium Assembly Positive Regulation Of Spindle Assembly
Pathways		MHC class II antigen presentation	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain AURKA Activation by TPX2
Drugs		Relatlimab	None
Diseases		None	Primary microcephaly (MCPH) Seckel syndrome
GWAS		Blood protein levels ( 30072576 )	No GWAS studies recorded
Interacting Genes		2 interacting genes: CEBPZ CPAP	16 interacting genes: ATN1 BCCIP CIC CREBBP EPB41 FBXO7 GFI1B LAG3 LYST MTDH SHANK3 STAT5A STAT5B TUBG1 YWHAG YWHAZ
Entrez ID		3902	55835
HPRD ID		01077	09876
Ensembl ID		ENSG00000089692	ENSG00000151849
Uniprot IDs		P18627	A8K8P1 F6VUX8 Q9HC77
PDB IDs		7TZG 7TZH 7UM3 8SO3 8SR0 9BF9	5EIB 5ITZ 7Q1E 7Q1F 7Z0F 7Z0G
GO Terms Enriched among Interactors		None	Natural Killer Cell Mediated Immunity Natural Killer Cell Mediated Cytotoxicity Cell Killing Leukocyte Mediated Cytotoxicity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Development Of Secondary Female Sexual Characteristics Development Of Secondary Male Sexual Characteristics Lymphocyte Mediated Immunity Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Leukocyte Mediated Immunity Development Of Secondary Sexual Characteristics Regulation Of Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Lymphocyte Activation Regulation Of Natural Killer Cell Mediated Immunity Regulation Of Interleukin-2 Production Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Leukocyte Activation Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Gamma-delta T Cell Differentiation Mucosa-associated Lymphoid Tissue Development Peyer's Patch Development Luteinization Negative Regulation Of Erythrocyte Differentiation Activated T Cell Proliferation Regulation Of Immune System Process Regulation Of Hemopoiesis Positive Regulation Of Cell Killing Taurine Metabolic Process Positive Regulation Of Natural Killer Cell Differentiation Regulation Of Innate Immune Response Negative Regulation Of Cell Activation Regulation Of Lymphocyte Differentiation Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Regulation Of Cell Development Regulation Of Natural Killer Cell Differentiation Regulation Of Lymphocyte Activation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Immune Effector Process Negative Regulation Of Immune System Process Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Developmental Process Myeloid Cell Apoptotic Process Positive Regulation Of B Cell Differentiation Regulation Of Immune Response Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Innate Immune Response