KCNA1 and DOLK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNA1	DOLK
Description		potassium voltage-gated channel subfamily A member 1	dolichol kinase
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Cell Junction Axon Dendrite Cytoplasmic Vesicle Paranode Region Of Axon Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Axon Initial Segment Perikaryon Axon Terminus Juxtaparanode Region Of Axon Synapse Anchoring Junction Presynapse	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Disordered Domain Specific Binding	Dolichol Kinase Activity Protein Binding Kinase Activity Transferase Activity
	Biological Process	Action Potential Startle Response Monoatomic Ion Transport Potassium Ion Transport Regulation Of Muscle Contraction Neuroblast Proliferation Brain Development Cell Communication By Electrical Coupling Magnesium Ion Homeostasis Neuronal Action Potential Hippocampus Development Neuronal Signal Transduction Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Neuromuscular Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Homooligomerization Transmembrane Transport Cellular Response To Magnesium Ion Potassium Ion Transmembrane Transport Membrane Repolarization During Action Potential	Protein N-linked Glycosylation Dolichyl Diphosphate Biosynthetic Process Lipid Metabolic Process Dolichyl Monophosphate Biosynthetic Process Dolichol Phosphate Mannose Biosynthetic Process
Pathways		Voltage gated Potassium channels	Synthesis of dolichyl-phosphate Defective DOLK causes DOLK-CDG
Drugs		Enflurane Amitriptyline Isoflurane Methoxyflurane Promethazine Miconazole Desflurane Dalfampridine Tetraethylammonium Amifampridine
Diseases		Episodic ataxias	Congenital disorders of glycosylation (CDG) type I
GWAS
Interacting Genes		17 interacting genes: APOL2 DLG1 DLG4 DOLK FCER1G GPR152 GPR42 IER3IP1 JAGN1 KCNA10 KCNA2 KCNA3 KCNE4 MAL SGTA TMEM14B TMEM86A	21 interacting genes: APPBP2 CD79A CHODL CREB3 CREB3L1 EDA FAM209A FNDC9 GALNT8 GJA8 GPX8 KCNA1 KCNA10 KCNA3 KCNA6 SLC7A6 SYNPR TMEM45B TMEM80 UBQLN1 VSIR
Entrez ID		3736	22845
HPRD ID		08885	15525
Ensembl ID		ENSG00000111262	ENSG00000175283
Uniprot IDs		Q09470	A0A0S2Z597 Q9UPQ8
PDB IDs
Enriched GO Terms of Interacting Partners?		Delayed Rectifier Potassium Channel Activity Membrane Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Activity Regulation Of Membrane Potential Action Potential Endoplasmic Reticulum Membrane Monoatomic Ion Channel Complex Endoplasmic Reticulum Localization Within Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Protein Insertion Into Membrane Juxtaparanode Region Of Axon Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Across Plasma Membrane Insulin Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization Membrane Raft Organization Ionotropic Glutamate Receptor Binding Protein Insertion Into ER Membrane Leukocyte Mediated Immunity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Monoatomic Ion Channel Activity Cellular Localization P2Y1 Nucleotide Receptor Binding IgE Receptor Activity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Dolichol Kinase Activity Potassium Channel Regulator Activity Protein Homooligomerization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Establishment Of Protein Localization To Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Cell Periphery Protein Localization To Synapse Establishment Of Protein Localization Positive Regulation Of Type I Hypersensitivity Fc-epsilon Receptor I Complex Export Across Plasma Membrane Optic Nerve Structural Organization	Membrane Delayed Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Potassium Channel Activity Voltage-gated Potassium Channel Complex Action Potential Monoatomic Ion Channel Complex Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Potassium Ion Transport Protein Homooligomerization Regulation Of Response To Endoplasmic Reticulum Stress Protein Complex Oligomerization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway L-lysine:L-arginine Antiporter Activity Positive Regulation Of Deacetylase Activity Negative Regulation Of Store-operated Calcium Channel Activity Positive Regulation Of Collagen Catabolic Process Regulation Of Collagen Metabolic Process Regulation Of Intrinsic Apoptotic Signaling Pathway
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