KCNA1 and KCNA3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		KCNA1	KCNA3
Description		potassium voltage-gated channel subfamily A member 1	potassium voltage-gated channel subfamily A member 3
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Cell Junction Axon Dendrite Cytoplasmic Vesicle Paranode Region Of Axon Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Axon Initial Segment Perikaryon Axon Terminus Juxtaparanode Region Of Axon Synapse Anchoring Junction Presynapse	Cytoplasm Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Axon Monoatomic Ion Channel Complex Perinuclear Region Of Cytoplasm
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Disordered Domain Specific Binding	Monoatomic Ion Channel Activity Voltage-gated Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding
	Biological Process	Action Potential Startle Response Monoatomic Ion Transport Potassium Ion Transport Regulation Of Muscle Contraction Neuroblast Proliferation Brain Development Cell Communication By Electrical Coupling Magnesium Ion Homeostasis Neuronal Action Potential Hippocampus Development Neuronal Signal Transduction Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Neuromuscular Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Homooligomerization Transmembrane Transport Cellular Response To Magnesium Ion Potassium Ion Transmembrane Transport Membrane Repolarization During Action Potential	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Voltage gated Potassium channels	Voltage gated Potassium channels
Drugs		Enflurane Amitriptyline Isoflurane Methoxyflurane Promethazine Miconazole Desflurane Dalfampridine Tetraethylammonium Amifampridine	Enflurane Clofazimine Promethazine Miconazole Dalfampridine
Diseases		Episodic ataxias
GWAS			Acute lymphoblastic leukemia (childhood) ( 22076464)
Interacting Genes		17 interacting genes: APOL2 DLG1 DLG4 DOLK FCER1G GPR152 GPR42 IER3IP1 JAGN1 KCNA10 KCNA2 KCNA3 KCNE4 MAL SGTA TMEM14B TMEM86A	10 interacting genes: BAX CAV1 CD3D DEFB4A DLG1 DLG4 DOLK IL16 KCNA1 KCNA2
Entrez ID		3736	3738
HPRD ID		08885	15937
Ensembl ID		ENSG00000111262	ENSG00000177272
Uniprot IDs		Q09470	P22001
PDB IDs			4BGC 7EJ1 7EJ2 7SSV 7SSX 7SSY 7SSZ 8DFL
Enriched GO Terms of Interacting Partners?		Delayed Rectifier Potassium Channel Activity Membrane Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Activity Regulation Of Membrane Potential Action Potential Endoplasmic Reticulum Membrane Monoatomic Ion Channel Complex Endoplasmic Reticulum Localization Within Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Protein Insertion Into Membrane Juxtaparanode Region Of Axon Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Across Plasma Membrane Insulin Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization Membrane Raft Organization Ionotropic Glutamate Receptor Binding Protein Insertion Into ER Membrane Leukocyte Mediated Immunity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Monoatomic Ion Channel Activity Cellular Localization P2Y1 Nucleotide Receptor Binding IgE Receptor Activity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Dolichol Kinase Activity Potassium Channel Regulator Activity Protein Homooligomerization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Establishment Of Protein Localization To Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Cell Periphery Protein Localization To Synapse Establishment Of Protein Localization Positive Regulation Of Type I Hypersensitivity Fc-epsilon Receptor I Complex Export Across Plasma Membrane Optic Nerve Structural Organization	Juxtaparanode Region Of Axon Regulation Of Membrane Potential Endoplasmic Reticulum Voltage-gated Potassium Channel Complex Regulation Of Ventricular Cardiac Muscle Cell Action Potential Positive Regulation Of Calcium Ion Transport Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Regulation Of Monoatomic Ion Transport Epithelial Cell Proliferation Cellular Response To Topologically Incorrect Protein Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Metal Ion Transport Signal Transduction Regulation Of Transport Negative Regulation Of Fibroblast Proliferation Positive Regulation Of Monoatomic Ion Transport Membrane Raft Organization Regulation Of Cardiac Muscle Cell Contraction Regulation Of Muscle Contraction Regulation Of Cardiac Muscle Cell Action Potential Protein Localization To Postsynaptic Membrane Membrane Repolarization During Action Potential Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Protein Localization To Postsynapse Ionotropic Glutamate Receptor Binding Membrane Repolarization Neuronal Action Potential Axon Initial Segment Delayed Rectifier Potassium Channel Activity Localization Within Membrane Endothelial Cell Proliferation Cell Junction Positive Regulation Of Response To Endoplasmic Reticulum Stress Endoplasmic Reticulum Membrane Regulation Of System Process Protein-macromolecule Adaptor Activity Regulation Of Calcium Ion Transport Protein Localization To Cell Periphery Metal Ion Transport Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Muscle System Process Receptor Localization To Synapse Receptor Clustering Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Immune System Process T Cell Homeostatic Proliferation Positive Regulation Of Calcium Ion Transmembrane Transport BAX Complex Cell Surface Receptor Signaling Pathway Release Of Matrix Enzymes From Mitochondria
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