LAG3 and CLEC4D

Data Source: HiPPIP (Novel)

		LAG3	CLEC4D
Name		lymphocyte activating 3	C-type lectin domain family 4 member D
Structure
GO Annotations	Cellular Component	Extracellular Region Plasma Membrane External Side Of Plasma Membrane Cell Surface Membrane	Plasma Membrane External Side Of Plasma Membrane Membrane Specific Granule Membrane Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Antigen Binding Transmembrane Signaling Receptor Activity Protein Binding MHC Class II Protein Binding	Protein Binding D-mannose Binding Carbohydrate Binding Immunoglobulin Receptor Binding Pattern Recognition Receptor Activity Metal Ion Binding
	Biological Process	Adaptive Immune Response Plasmacytoid Dendritic Cell Activation Immune System Process Cell Surface Receptor Signaling Pathway Negative Regulation Of Interleukin-2 Production T Cell Activation Natural Killer Cell Mediated Cytotoxicity Innate Immune Response Negative Regulation Of Regulatory T Cell Differentiation Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response Negative Regulation Of T Cell Activation	Adaptive Immune Response T Cell Differentiation Involved In Immune Response Immune System Process Positive Regulation Of Myeloid Dendritic Cell Activation Fc-gamma Receptor Signaling Pathway Defense Response To Bacterium Positive Regulation Of Canonical NF-kappaB Signal Transduction Innate Immune Response Antifungal Innate Immune Response
Pathways		MHC class II antigen presentation	Dectin-2 family Neutrophil degranulation
Drugs		Relatlimab	None
GWAS		Blood protein levels ( 30072576 )	No GWAS studies recorded
Novel Interactors		5 novel interactors: ALCAM CLEC4D GNAI2 KCNA1 UBE2E3	1 novel interactors: LAG3
Interacting Genes		2 interacting genes: CEBPZ CPAP	4 interacting genes: ACTN2 ANKRD46 JAGN1 ZDHHC22
Entrez ID		3902	338339
HPRD ID		01077	13074
Ensembl ID		ENSG00000089692	ENSG00000166527
Uniprot IDs		P18627	Q8WXI8
PDB IDs		7TZG 7TZH 7UM3 8SO3 8SR0 9BF9	2LS8 3WHD
GO Terms Enriched among Interactors		None	Protein Localization To Plasma Membrane Titin Z Domain Binding Structural Constituent Of Postsynaptic Actin Cytoskeleton Protein Localization To Cell Periphery Channel Activator Activity Microspike Assembly Phospholipase C-activating Angiotensin-activated Signaling Pathway Actin Filament Uncapping FATZ Binding Negative Regulation Of Protein Localization LIM Domain Binding Plasmacytoid Dendritic Cell Activation Negative Regulation Of Regulatory T Cell Differentiation Leukocyte Mediated Immunity MHC Class II Protein Binding Granulocyte Colony-stimulating Factor Signaling Pathway