KCNA1 and KCNA10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNA1	KCNA10
Description		potassium voltage-gated channel subfamily A member 1	potassium voltage-gated channel subfamily A member 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Cell Surface Membrane Cell Junction Axon Dendrite Cytoplasmic Vesicle Paranode Region Of Axon Monoatomic Ion Channel Complex Presynaptic Membrane Cell Projection Neuronal Cell Body Axon Initial Segment Perikaryon Axon Terminus Juxtaparanode Region Of Axon Synapse Anchoring Junction Presynapse	Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding Disordered Domain Specific Binding	Monoatomic Ion Channel Activity Intracellularly Cyclic Nucleotide-activated Monoatomic Cation Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding
	Biological Process	Action Potential Startle Response Monoatomic Ion Transport Potassium Ion Transport Regulation Of Muscle Contraction Neuroblast Proliferation Brain Development Cell Communication By Electrical Coupling Magnesium Ion Homeostasis Neuronal Action Potential Hippocampus Development Neuronal Signal Transduction Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Neuromuscular Process Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Homooligomerization Transmembrane Transport Cellular Response To Magnesium Ion Potassium Ion Transmembrane Transport Membrane Repolarization During Action Potential	Action Potential Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Protein Homooligomerization Transmembrane Transport Potassium Ion Transmembrane Transport
Pathways		Voltage gated Potassium channels	Voltage gated Potassium channels
Drugs		Enflurane Amitriptyline Isoflurane Methoxyflurane Promethazine Miconazole Desflurane Dalfampridine Tetraethylammonium Amifampridine	Enflurane Promethazine Miconazole Dalfampridine
Diseases		Episodic ataxias
GWAS			Bitter taste perception (phenylthiocarbamide) in obesity with metabolic syndrome ( 31005965) Response to bupropion in depression ( 27622933)
Interacting Genes		17 interacting genes: APOL2 DLG1 DLG4 DOLK FCER1G GPR152 GPR42 IER3IP1 JAGN1 KCNA10 KCNA2 KCNA3 KCNE4 MAL SGTA TMEM14B TMEM86A	6 interacting genes: DOLK KCNA1 MAL POMP SGTA TMBIM6
Entrez ID		3736	3744
HPRD ID		08885	03882
Ensembl ID		ENSG00000111262	ENSG00000143105
Uniprot IDs		Q09470	Q16322
PDB IDs
Enriched GO Terms of Interacting Partners?		Delayed Rectifier Potassium Channel Activity Membrane Voltage-gated Potassium Channel Complex Voltage-gated Potassium Channel Activity Potassium Channel Activity Regulation Of Membrane Potential Action Potential Endoplasmic Reticulum Membrane Monoatomic Ion Channel Complex Endoplasmic Reticulum Localization Within Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Protein Insertion Into Membrane Juxtaparanode Region Of Axon Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Ventricular Cardiac Muscle Cell Membrane Repolarization Potassium Ion Export Across Plasma Membrane Insulin Metabolic Process Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Repolarization Membrane Raft Organization Ionotropic Glutamate Receptor Binding Protein Insertion Into ER Membrane Leukocyte Mediated Immunity Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Monoatomic Ion Channel Activity Cellular Localization P2Y1 Nucleotide Receptor Binding IgE Receptor Activity Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Dolichol Kinase Activity Potassium Channel Regulator Activity Protein Homooligomerization Receptor Localization To Synapse Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Clustering Establishment Of Protein Localization To Membrane Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Cell Periphery Protein Localization To Synapse Establishment Of Protein Localization Positive Regulation Of Type I Hypersensitivity Fc-epsilon Receptor I Complex Export Across Plasma Membrane Optic Nerve Structural Organization	Endoplasmic Reticulum Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Protein Insertion Into Membrane Negative Regulation Of Response To Endoplasmic Reticulum Stress Neuron Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Dolichol Kinase Activity Regulation Of Response To Endoplasmic Reticulum Stress TRC Complex Endoribonuclease Inhibitor Activity Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Protein Localization To Paranode Region Of Axon Membrane Raft Polarization BAT3 Complex Binding Dolichol Phosphate Mannose Biosynthetic Process Dolichyl Monophosphate Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Neuronal Signal Transduction Cellular Response To Magnesium Ion Membrane Raft Distribution Establishment Of Protein Localization To Membrane Peptidase Activator Activity Involved In Apoptotic Process Negative Regulation Of ERAD Pathway Negative Regulation Of Calcium Ion Transport Into Cytosol Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of IRE1-mediated Unfolded Protein Response Membrane Raft Localization Response To Endoplasmic Reticulum Stress Juxtaparanode Region Of Axon Paranode Region Of Axon Magnesium Ion Homeostasis Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Membrane Protein Localization To Axon Schmidt-Lanterman Incisure Structural Constituent Of Myelin Sheath Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Central Nervous System Myelination Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Negative Regulation Of Cellular Response To Hypoxia IRE1-mediated Unfolded Protein Response Negative Regulation Of Immunoglobulin Production Proteasome Assembly Apical Protein Localization Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of IRE1-mediated Unfolded Protein Response Negative Regulation Of Cytosolic Calcium Ion Concentration Response To Magnesium Ion Startle Response Positive Regulation Of ERAD Pathway
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