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KPNA3 and NFE2L2
Number of citations of the paper that reports this interaction (PubMedID
21988832
)
38
Data Source:
BioGRID
(two hybrid)
KPNA3
NFE2L2
Description
karyopherin subunit alpha 3
NFE2 like bZIP transcription factor 2
Image
No pdb structure
GO Annotations
Cellular Component
Nucleus
Nuclear Pore
Nucleoplasm
Cytoplasm
Cytosol
NLS-dependent Protein Nuclear Import Complex
Host Cell
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Golgi Apparatus
Centrosome
Cytosol
Plasma Membrane
Mediator Complex
Protein-DNA Complex
Ciliary Basal Body
RNA Polymerase II Transcription Regulator Complex
Molecular Function
Protein Binding
Nuclear Localization Sequence Binding
Nuclear Import Signal Receptor Activity
Transcription Cis-regulatory Region Binding
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Transcription Coregulator Binding
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA Binding
DNA-binding Transcription Factor Activity
Protein Binding
Protein Domain Specific Binding
Ubiquitin Protein Ligase Binding
Sequence-specific DNA Binding
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Molecular Condensate Scaffold Activity
Biological Process
Protein Import Into Nucleus
NLS-bearing Protein Import Into Nucleus
Protein Transport
Symbiont Entry Into Host Cell
Protein-containing Complex Assembly
Viral Penetration Into Host Nucleus
Response To Ischemia
Regulation Of DNA-templated Transcription
Regulation Of Transcription By RNA Polymerase II
Inflammatory Response
Response To Oxidative Stress
Response To Xenobiotic Stimulus
Gene Expression
Proteasomal Ubiquitin-independent Protein Catabolic Process
Positive Regulation Of Gene Expression
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Neuron Projection Development
Protein Ubiquitination
Positive Regulation Of Blood Coagulation
Endoplasmic Reticulum Unfolded Protein Response
Cellular Response To Oxidative Stress
Response To Endoplasmic Reticulum Stress
PERK-mediated Unfolded Protein Response
Cellular Response To Glucose Starvation
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Positive Regulation Of Blood Vessel Endothelial Cell Migration
Regulation Of Innate Immune Response
Cell Redox Homeostasis
Positive Regulation Of Angiogenesis
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Embryonic Development
Aflatoxin Catabolic Process
Positive Regulation Of D-glucose Import
Cellular Response To Methionine
Response To Caloric Restriction
Cellular Response To Hydrogen Peroxide
Cellular Response To Copper Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Cellular Response To Fluid Shear Stress
Cellular Response To Laminar Fluid Shear Stress
Reactive Oxygen Species Metabolic Process
Negative Regulation Of Ferroptosis
Integrated Stress Response Signaling
Negative Regulation Of Cellular Response To Hypoxia
Regulation Of Cellular Response To Oxidative Stress
Negative Regulation Of Hematopoietic Stem Cell Differentiation
Negative Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway
Positive Regulation Of Glutathione Biosynthetic Process
Positive Regulation Of ERAD Pathway
Cellular Response To Angiotensin
Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process
Regulation Of Removal Of Superoxide Radicals
Negative Regulation Of Endothelial Cell Apoptotic Process
Positive Regulation Of Reactive Oxygen Species Metabolic Process
Pathways
ISG15 antiviral mechanism
NS1 Mediated Effects on Host Pathways
Neddylation
Potential therapeutics for SARS
Regulation of HMOX1 expression and activity
Heme signaling
KEAP1-NFE2L2 pathway
KEAP1-NFE2L2 pathway
Nuclear events mediated by NFE2L2
GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2
NFE2L2 regulating TCA cycle genes
NFE2L2 regulating inflammation associated genes
NFE2L2 regulating anti-oxidant/detoxification enzymes
NFE2L2 regulates pentose phosphate pathway genes
NFE2L2 regulating tumorigenic genes
NFE2L2 regulating MDR associated enzymes
NFE2L2 regulating ER-stress associated genes
Regulation of NFE2L2 gene expression
Regulation of NFE2L2 gene expression
Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS
Inflammatory skin disease (
25574825
)
Menopause (age at onset) (
22267201
)
Obesity-related traits (
23251661
)
Refractive error (
32231278
)
Reticulocyte count (
32888494
)
Reticulocyte fraction of red cells (
32888494
)
Triiodothyronine/thyroxine ratio (
30824882
)
A body shape index (
34021172
)
Estimated glomerular filtration rate (
30604766
31152163
31451708
)
Estimated glomerular filtration rate in non-diabetics (
31451708
)
HDL cholesterol levels (
32203549
)
Refractive error (
32231278
)
Interacting Genes
51 interacting genes:
APOL6
ARNT
ATM
ATOSB
BAHD1
CCDC102B
CDKN1B
COIL
EPAS1
EPHA2
ERCC3
ESR2
FAM50B
FTL
GATA6
GRB10
GTF2H1
GTF2IRD1
HEXIM2
HIF1A
HNRNPC
HSPB1
KAT5
KPNB1
L3MBTL4
MAPK9
MAT2B
MVP
MYOD1
NFE2L2
NFKB1
NMNAT1
NRIP1
OGT
POLR3C
RAD52
RCC1
RPRD1A
SLC5A11
SPMIP9
TGM2
TNIP3
TSSC4
UVSSA
ZBTB24
ZCCHC10
ZCCHC12
ZFTRAF1
ZNF131
ZNF76
ZNF764
85 interacting genes:
APEX1
ARFIP2
ARPC2
ATF3
ATF4
ATM
ATR
BPTF
BRPF1
BRPF3
BTRC
CASP1
CASP3
CDH1
CEBPG
CERS2
CFAP299
CHD6
CLIC6
COPS7A
CREB3
CREBBP
CREBL2
CREBZF
DDIT3
EIF2AK3
EIF3J
ELF1
ELF3
ELF4
ELF5
ELK1
ETV1
ETV4
ETV6
FBXW11
FOSB
FOSL2
GSK3B
HNRNPR
IRF2
JUN
JUND
KDM1A
KEAP1
KPNA2
KPNA3
KPNA4
LEF1
MAFF
MAFG
MAFK
MAP2K6
MAPK7
MAPK8
NCOR2
NFAT5
NFE2
NFE2L3
PAQR4
PMF1
PPARG
PRKCA
PRKCD
RBMX
REL
RELA
SMAD1
SP140
SPIC
STAT3
SUMO1
SUMO2
TADA2A
TBP
TEF
TIGAR
TNNT1
TRIM24
TRIM41
USP11
USP8
WAC
ZBTB24
ZNF396
Entrez ID
3839
4780
HPRD ID
03536
02732
Ensembl ID
ENSG00000102753
ENSG00000116044
Uniprot IDs
O00505
A0A8V8TN14
A0A8V8TPA8
Q16236
PDB IDs
2FLU
2LZ1
3ZGC
4IFL
5WFV
6T7V
7K28
7K29
7K2A
7K2B
7K2C
7K2D
7K2E
7K2K
7O7B
7X5E
7X5F
7X5G
8EJR
8EJS
Enriched GO Terms of Interacting Partners
?
Nucleus
Regulation Of Nucleobase-containing Compound Metabolic Process
Nucleoplasm
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Sequence-specific DNA Binding
Regulation Of Macromolecule Biosynthetic Process
RNA Polymerase II-specific DNA-binding Transcription Factor Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin
Positive Regulation Of RNA Metabolic Process
Regulation Of Gene Expression
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
Cellular Response To Estradiol Stimulus
Protein Binding
Positive Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Transcription Regulator Complex
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
Positive Regulation Of Biosynthetic Process
Response To Oxidative Stress
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Metabolic Process
Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway
Negative Regulation Of Biosynthetic Process
Regulation Of Protein Modification Process
Negative Regulation Of DNA-templated Transcription
Transcription Coactivator Binding
Negative Regulation Of RNA Biosynthetic Process
DNA Binding
Negative Regulation Of Macromolecule Metabolic Process
Nucleotide-excision Repair
DNA-binding Transcription Factor Activity
Gene Expression
Positive Regulation Of Macromolecule Metabolic Process
Cellular Response To Stress
Cellular Response To Oxidative Stress
Cellular Senescence
Cellular Response To Oxygen-containing Compound
Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Metabolic Process
DNA Double-strand Break Processing
Embryonic Placenta Development
Macromolecule Biosynthetic Process
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Biosynthetic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Positive Regulation Of Metabolic Process
Positive Regulation Of Biosynthetic Process
Positive Regulation Of Macromolecule Biosynthetic Process
Regulation Of Transcription By RNA Polymerase II
DNA-binding Transcription Factor Activity
Chromatin
Nucleus
Positive Regulation Of Transcription By RNA Polymerase II
Regulation Of Macromolecule Biosynthetic Process
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
Regulation Of Macromolecule Metabolic Process
Regulation Of Metabolic Process
Regulation Of Gene Expression
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
Nucleoplasm
RNA Polymerase II Transcription Regulator Complex
Sequence-specific DNA Binding
Sequence-specific Double-stranded DNA Binding
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Negative Regulation Of Metabolic Process
Integrated Stress Response Signaling
Intracellular Signaling Cassette
Negative Regulation Of Macromolecule Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Metabolic Process
DNA-templated Transcription
Negative Regulation Of Transcription By RNA Polymerase II
Intracellular Signal Transduction
Transcription Cis-regulatory Region Binding
Transcription By RNA Polymerase II
Cellular Response To Stress
Response To Stress
Chromatin Binding
Transcription Regulator Complex
Cellular Response To Chemical Stress
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