KPNA3 and SLC5A11

Number of citations of the paper that reports this interaction (PubMedID 25910212)
47

Data Source:
BioGRID (two hybrid)

		KPNA3	SLC5A11
Description		karyopherin subunit alpha 3	solute carrier family 5 member 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol NLS-dependent Protein Nuclear Import Complex Host Cell	Plasma Membrane Membrane Apical Plasma Membrane
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	Myo-inositol Transmembrane Transporter Activity D-glucose:sodium Symporter Activity Protein Binding Polyol Transmembrane Transporter Activity Symporter Activity Transmembrane Transporter Activity
	Biological Process	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Symbiont Entry Into Host Cell Protein-containing Complex Assembly Viral Penetration Into Host Nucleus	Monoatomic Ion Transport Sodium Ion Transport Apoptotic Process Hexose Transmembrane Transport Polyol Transmembrane Transport Myo-inositol Transport Carbohydrate Transmembrane Transport Sodium Ion Transmembrane Transport Transmembrane Transport
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	Inositol transporters
Drugs
Diseases
GWAS		Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 22267201) Obesity-related traits ( 23251661) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triiodothyronine/thyroxine ratio ( 30824882)	Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Heel bone mineral density ( 30598549) Lupus nephritis in systemic lupus erythematosus ( 24925725) Urinary metabolite levels in chronic kidney disease ( 31959995) Urinary metabolites ( 26352407)
Interacting Genes		51 interacting genes: APOL6 ARNT ATM ATOSB BAHD1 CCDC102B CDKN1B COIL EPAS1 EPHA2 ERCC3 ESR2 FAM50B FTL GATA6 GRB10 GTF2H1 GTF2IRD1 HEXIM2 HIF1A HNRNPC HSPB1 KAT5 KPNB1 L3MBTL4 MAPK9 MAT2B MVP MYOD1 NFE2L2 NFKB1 NMNAT1 NRIP1 OGT POLR3C RAD52 RCC1 RPRD1A SLC5A11 SPMIP9 TGM2 TNIP3 TSSC4 UVSSA ZBTB24 ZCCHC10 ZCCHC12 ZFTRAF1 ZNF131 ZNF76 ZNF764	1 interacting genes: KPNA3
Entrez ID		3839	115584
HPRD ID		03536	11581
Ensembl ID		ENSG00000102753	ENSG00000158865
Uniprot IDs		O00505	B7Z8N3 Q8WWX8
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estradiol Stimulus Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Transcription Coactivator Binding Negative Regulation Of RNA Biosynthetic Process DNA Binding Negative Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair DNA-binding Transcription Factor Activity Gene Expression Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Cellular Response To Oxidative Stress Cellular Senescence Cellular Response To Oxygen-containing Compound Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA Double-strand Break Processing Embryonic Placenta Development Macromolecule Biosynthetic Process	Viral Penetration Into Host Nucleus Intracellular Transport Of Virus Host Cell NLS-dependent Protein Nuclear Import Complex NLS-bearing Protein Import Into Nucleus Nuclear Import Signal Receptor Activity Nuclear Localization Sequence Binding Nuclear Pore Symbiont Entry Into Host Cell Protein Import Into Nucleus Import Into Nucleus Viral Process Biological Process Involved In Interaction With Host Protein Localization To Nucleus Nuclear Transport Nucleocytoplasmic Transport Establishment Of Protein Localization To Organelle
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