KPNA3 and UVSSA

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KPNA3	UVSSA
Description		karyopherin subunit alpha 3	UV stimulated scaffold protein A
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol NLS-dependent Protein Nuclear Import Complex Host Cell	Nucleus Nucleoplasm Chromosome Site Of DNA Damage
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	RNA Polymerase II Complex Binding Protein Binding Zinc Ion Binding Metal Ion Binding Chromatin-protein Adaptor Activity RNA Polymerase Inhibitor Activity
	Biological Process	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Symbiont Entry Into Host Cell Protein-containing Complex Assembly Viral Penetration Into Host Nucleus	DNA Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization DNA Damage Response Response To UV Protein Ubiquitination
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs
Diseases
GWAS		Inflammatory skin disease ( 25574825) Menopause (age at onset) ( 22267201) Obesity-related traits ( 23251661) Refractive error ( 32231278) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Triiodothyronine/thyroxine ratio ( 30824882)	Appendicular lean mass ( 33097823) Chronotype ( 30696823)
Interacting Genes		51 interacting genes: APOL6 ARNT ATM ATOSB BAHD1 CCDC102B CDKN1B COIL EPAS1 EPHA2 ERCC3 ESR2 FAM50B FTL GATA6 GRB10 GTF2H1 GTF2IRD1 HEXIM2 HIF1A HNRNPC HSPB1 KAT5 KPNB1 L3MBTL4 MAPK9 MAT2B MVP MYOD1 NFE2L2 NFKB1 NMNAT1 NRIP1 OGT POLR3C RAD52 RCC1 RPRD1A SLC5A11 SPMIP9 TGM2 TNIP3 TSSC4 UVSSA ZBTB24 ZCCHC10 ZCCHC12 ZFTRAF1 ZNF131 ZNF76 ZNF764	8 interacting genes: ERCC8 KPNA3 MAGEA4 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1
Entrez ID		3839	57654
HPRD ID		03536	17216
Ensembl ID		ENSG00000102753	ENSG00000163945
Uniprot IDs		O00505	A0A7I2V4K1 Q2YD98
PDB IDs			5XV8 7OO3 7OOP 7OPC 7OPD 8B3D 8B3G 8QH5 9BZ0 9ER2 9FD2
Enriched GO Terms of Interacting Partners?		Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estradiol Stimulus Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Transcription Coactivator Binding Negative Regulation Of RNA Biosynthetic Process DNA Binding Negative Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair DNA-binding Transcription Factor Activity Gene Expression Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Cellular Response To Oxidative Stress Cellular Senescence Cellular Response To Oxygen-containing Compound Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA Double-strand Break Processing Embryonic Placenta Development Macromolecule Biosynthetic Process	Ubiquitin Conjugating Enzyme Activity Protein Polyubiquitination Protein K48-linked Ubiquitination Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Ubiquitination Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Macromolecule Catabolic Process Proteolysis Protein Autoubiquitination Protein Modification Process Catabolic Process Protein K6-linked Ubiquitination Protein K11-linked Ubiquitination ATP Binding Protein Monoubiquitination Nucleus Regulation Of Transcription-coupled Nucleotide-excision Repair Nucleotide Binding Negative Regulation Of BMP Signaling Pathway Ubiquitin Protein Ligase Activity Transferase Activity Protein Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Regulation Of BMP Signaling Pathway Negative Regulation Of Cellular Response To Growth Factor Stimulus Viral Penetration Into Host Nucleus ISG15 Transferase Activity Protein Catabolic Process Nucleoplasm Nucleotide-excision Repair Complex Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway ISG15-protein Conjugation Intracellular Transport Of Virus Protein-containing Complex Host Cell NLS-dependent Protein Nuclear Import Complex Double-strand Break Repair Via Classical Nonhomologous End Joining Single Strand Break Repair Transcription-coupled Nucleotide-excision Repair Protein K29-linked Ubiquitination Cul4A-RING E3 Ubiquitin Ligase Complex Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Protein K27-linked Ubiquitination
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