KPNA3 and ZNF764

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		KPNA3	ZNF764
Name		karyopherin subunit alpha 3	zinc finger protein 764
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nuclear Pore Nucleoplasm Cytoplasm Cytosol NLS-dependent Protein Nuclear Import Complex Host Cell	Nucleus
	Molecular Function	Protein Binding Nuclear Localization Sequence Binding Nuclear Import Signal Receptor Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding Metal Ion Binding
	Biological Process	Protein Import Into Nucleus NLS-bearing Protein Import Into Nucleus Protein Transport Symbiont Entry Into Host Cell Protein-containing Complex Assembly Viral Penetration Into Host Nucleus	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cellular Response To Glucocorticoid Stimulus
Pathways		ISG15 antiviral mechanism NS1 Mediated Effects on Host Pathways	Generic Transcription Pathway
GWAS		Inflammatory skin disease ( 25574825 ) Menopause (age at onset) ( 22267201 ) Obesity-related traits ( 23251661 ) Refractive error ( 32231278 ) Reticulocyte count ( 32888494 ) Reticulocyte fraction of red cells ( 32888494 ) Triiodothyronine/thyroxine ratio ( 30824882 )	No GWAS studies recorded
Interacting Genes		51 interacting genes: APOL6 ARNT ATM ATOSB BAHD1 CCDC102B CDKN1B COIL EPAS1 EPHA2 ERCC3 ESR2 FAM50B FTL GATA6 GRB10 GTF2H1 GTF2IRD1 HEXIM2 HIF1A HNRNPC HSPB1 KAT5 KPNB1 L3MBTL4 MAPK9 MAT2B MVP MYOD1 NFE2L2 NFKB1 NMNAT1 NRIP1 OGT POLR3C RAD52 RCC1 RPRD1A SLC5A11 SPMIP9 TGM2 TNIP3 TSSC4 UVSSA ZBTB24 ZCCHC10 ZCCHC12 ZFTRAF1 ZNF131 ZNF76 ZNF764	33 interacting genes: ARMC7 CBY2 CCDC125 CCDC85B CLK2 CYSRT1 DTX2 DVL3 FHL5 GOLGA6L9 HNRNPF HOOK1 KPNA3 KRTAP1-3 KRTAP10-7 KRTAP10-9 KRTAP12-2 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP4-4 MDFI MID2 MTUS2 PICK1 PLSCR1 PPP1R37 SUFU TRIM38 ZNF330 ZNF408 ZNF837 ZRANB1
Entrez ID		3839	92595
HPRD ID		03536	10072
Ensembl ID		ENSG00000102753	ENSG00000169951
Uniprot IDs		O00505	Q96H86
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Sequence-specific DNA Binding Regulation Of Macromolecule Biosynthetic Process RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Cellular Response To Estradiol Stimulus Protein Binding Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Regulator Complex Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of RNA Metabolic Process Positive Regulation Of Biosynthetic Process Response To Oxidative Stress Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Regulation Of Protein Modification Process Negative Regulation Of DNA-templated Transcription Transcription Coactivator Binding Negative Regulation Of RNA Biosynthetic Process DNA Binding Negative Regulation Of Macromolecule Metabolic Process Nucleotide-excision Repair DNA-binding Transcription Factor Activity Gene Expression Positive Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Cellular Response To Oxidative Stress Cellular Senescence Cellular Response To Oxygen-containing Compound Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Metabolic Process DNA Double-strand Break Processing Embryonic Placenta Development Macromolecule Biosynthetic Process	Keratin Filament Intermediate Filament Protein Binding Identical Protein Binding Hair Cycle