KPNA3 and MAT2B

Number of citations of the paper that reports this interaction (PMID 25416956)
0

Data Source:
BioGRID (two hybrid)

		KPNA3	MAT2B
Gene Name		karyopherin alpha 3 (importin alpha 4)	methionine adenosyltransferase II, beta
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Pore Nucleoplasm Cytosol	Intracellular Nucleus Mitochondrion Cytosol Methionine Adenosyltransferase Complex Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Nuclear Localization Sequence Binding Protein Transporter Activity	Enzyme Binding Methionine Adenosyltransferase Regulator Activity
	Biological Process	Protein Complex Assembly NLS-bearing Protein Import Into Nucleus Cytokine-mediated Signaling Pathway Viral Entry Into Host Cell Viral Penetration Into Host Nucleus	S-adenosylmethionine Biosynthetic Process One-carbon Metabolic Process Xenobiotic Metabolic Process Methylation Small Molecule Metabolic Process Regulation Of Catalytic Activity
Pathways		ISG15 antiviral mechanism Interferon Signaling Cytokine Signaling in Immune system Antiviral mechanism by IFN-stimulated genes	Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) Defective AHCY causes Hypermethioninemia with S-adenosylhomocysteine hydrolase deficiency (HMAHCHD) Defective MAT1A causes Methionine adenosyltransferase deficiency (MATD) Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency) Defective UGT1A4 causes hyperbilirubinemia Metabolic disorders of biological oxidation enzymes Phase II conjugation Methylation Defective UGT1A1 causes hyperbilirubinemia Defective SLC35D1 causes Schneckenbecken dysplasia (SCHBCKD) Biological oxidations Defective GGT1 causes Glutathionuria (GLUTH) Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201) Obesity-related traits ( 23251661)	Aging ( 22773346) Phospholipid levels (plasma) ( 21829377)
Protein-Protein Interactions		28 interactors: APOL6 CDKN1B COIL DDX21 EPHA2 ERCC3 FAM50B FTL GATA6 GTF2H1 HNRNPC KPNB1 MAT2B MTA1 MVP MYOD1 NFE2L2 NFKB1 NUP50 RCC1 RPRD1A SLC5A11 TEX37 TGM2 TSSC4 ZBTB24 ZCCHC10 ZNF131	6 interactors: APP FBXO25 KPNA3 KPNA4 MAT2A TRIM27
Entrez ID		3839	27430
HPRD ID		03536	05701
Ensembl ID		ENSG00000102753	ENSG00000038274
Uniprot IDs		O00505 Q8IYQ9	Q9NZL9
PDB IDs			2YDX 2YDY
Enriched GO Terms of Interacting Partners?		Viral Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Cellular Response To Stress Response To Organic Substance Nitrogen Compound Metabolic Process Gene Expression Nucleotide-excision Repair, DNA Damage Removal Transcription, DNA-templated Regulation Of Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Apoptotic Process Termination Of RNA Polymerase I Transcription Programmed Cell Death Transcription Elongation From RNA Polymerase I Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter DNA Catabolic Process Osteoblast Differentiation Transcription Initiation From RNA Polymerase I Promoter Cell Death Death 7-methylguanosine MRNA Capping Response To Abiotic Stimulus Transcription From RNA Polymerase I Promoter 7-methylguanosine RNA Capping Positive Regulation Of Metabolic Process Regulation Of Gene Expression Transcription-coupled Nucleotide-excision Repair Regulation Of Nitrogen Compound Metabolic Process Cellular Response To Stimulus Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription Positive Regulation Of Wound Healing Regulation Of Nucleic Acid-templated Transcription Cellular Response To DNA Damage Stimulus Regulation Of RNA Biosynthetic Process Response To Lipid Response To Estrogen Regulation Of Gene Expression, Epigenetic Negative Regulation Of Interleukin-12 Biosynthetic Process Nucleotide-excision Repair, DNA Duplex Unwinding Notochord Cell Development Regulation Of Cell Cycle Process Cellular Macromolecule Catabolic Process Macromolecule Biosynthetic Process	NLS-bearing Protein Import Into Nucleus Intracellular Transport Protein Import Into Nucleus Nuclear Import Negative Regulation Of Interleukin-2 Secretion Synaptic Growth At Neuromuscular Junction Viral Penetration Into Host Nucleus Protein Import Establishment Of Localization In Cell Collateral Sprouting In Absence Of Injury Protein Localization To Nucleus Collateral Sprouting Axon Midline Choice Point Recognition Cellular Localization S-adenosylmethionine Biosynthetic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Negative Regulation Of Calcium Ion Import Axon Choice Point Recognition Nucleocytoplasmic Transport Nuclear Transport Interferon-gamma Secretion Neuron Remodeling Establishment Of Protein Localization To Organelle
Tagcloud ?		alpha4 ataxias capicua desensitize erk ets etv etv1 etv4 etv5 give highlight hmg importin interconnections mechanistic modulating motivating multisite nls p90 pea3 phosphorylations polyoma relieved represses rsk s6 spinocerebellar	adenosyltransferase arfgap coimmunoprecipitation erk erk2 gateway git1 hepatology interacting interplay knocked mek mek1 methionine observe opposite orthotopic partner promoted proteomics pull raised recruits scaffold translated v1 v2 verified
Tagcloud (Difference) ?		alpha4 ataxias capicua desensitize ets etv etv1 etv4 etv5 give highlight hmg importin interconnections mechanistic modulating motivating multisite nls p90 pea3 phosphorylations polyoma relieved represses rsk s6 spinocerebellar	adenosyltransferase arfgap coimmunoprecipitation erk2 gateway git1 hepatology interacting interplay knocked mek mek1 methionine observe opposite orthotopic partner promoted proteomics pull raised recruits scaffold translated v1 v2 verified
Tagcloud (Intersection) ?		erk