KIR3DS1 and TYROBP

Number of citations: 24 (PubMedID 17202323)
Data Source: HPRD (in vivo)

		KIR3DS1	TYROBP
Name		killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1	transmembrane immune signaling adaptor TYROBP
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Cell Surface Membrane Secretory Granule Membrane
	Molecular Function	Protein Binding MHC Class I Receptor Activity	Signaling Receptor Binding Protein Binding Protein-macromolecule Adaptor Activity Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding Molecular Adaptor Activity
	Biological Process	Immune Response-regulating Signaling Pathway Immune Response Natural Killer Cell Activation	Negative Regulation Of Cytokine Production Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway Stimulatory C-type Lectin Receptor Signaling Pathway Natural Killer Cell Mediated Immunity Immune Effector Process Myeloid Leukocyte Activation Macrophage Activation Involved In Immune Response Microglial Cell Activation Involved In Immune Response Neutrophil Activation Involved In Immune Response T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Immune System Process Positive Regulation Of Immune System Process Defense Response Immune Response Cellular Defense Response Signal Transduction Cell Surface Receptor Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Gene Expression Actin Cytoskeleton Organization Osteoclast Differentiation Negative Regulation Of B Cell Proliferation Forebrain Development Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Negative Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Natural Killer Cell Activation Negative Regulation Of Transforming Growth Factor Beta1 Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of Macrophage Fusion Intracellular Signal Transduction Apoptotic Cell Clearance Response To Axon Injury Protein Stabilization Regulation Of Biological Quality Semaphorin-plexin Signaling Pathway Amyloid-beta Clearance Negative Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Microglial Cell Mediated Cytotoxicity Cellular Response To Amyloid-beta Positive Regulation Of Protein Localization To Cell Surface Regulation Of Osteoclast Development Positive Regulation Of Osteoclast Development
Pathways		DAP12 interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 interactions DAP12 signaling DAP12 signaling Signal regulatory protein family interactions Other semaphorin interactions Neutrophil degranulation
Diseases		None	Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS		No GWAS studies recorded	No GWAS studies recorded
Novel Interactors		2 novel interactors: KIR3DL1 LAIR1	None recorded
Interacting Genes		2 interacting genes: HLA-B TYROBP	15 interacting genes: CD300E CLEC5A KIR3DS1 KLRC3 KLRC4 KLRK1 NCR2 SIGLEC14 SIRPB1 SLC35B4 SYK TMEM86A TREM1 TREM2 ZAP70
Entrez ID		3813	7305
HPRD ID		10034	04996
Ensembl ID		Not available	ENSG00000011600
Uniprot IDs		A0A0G2JN05 O43469 Q14943 Q4KN23 Q99565	O43914 X6RGC9
PDB IDs		Not available	2L34 2L35 4WO1 4WOL 7Q5W
GO Terms Enriched among Interactors		Regulation Of Immune Response Immune Response Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Immune System Process Positive Regulation Of Cell Killing Immune Response-regulating Signaling Pathway Immune System Process Innate Immune Response Secretory Granule Membrane Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity Defense Response To Other Organism Defense Response To Symbiont Regulation Of Interleukin-6 Production HLA-B Specific Inhibitory MHC Class I Receptor Activity Leukocyte Mediated Immunity Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway TAP Binding Molecular Adaptor Activity Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Macrophage Fusion Response To Other Organism Microglial Cell Activation Involved In Immune Response Positive Regulation Of Immune Effector Process Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Transforming Growth Factor Beta1 Production Defense Response Response To External Biotic Stimulus Adaptive Immune Response Regulation Of T Cell Anergy T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell MHC Class I Protein Complex Regulation Of Osteoclast Development Detection Of Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of T Cell Tolerance Induction Immune Effector Process Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Transforming Growth Factor Beta Production Signaling Receptor Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Regulation Of Hemopoiesis Regulation Of Dendritic Cell Differentiation Regulation Of Innate Immune Response Negative Regulation Of B Cell Proliferation Regulation Of Tolerance Induction	Stimulatory C-type Lectin Receptor Signaling Pathway Cellular Response To Lectin Transmembrane Signaling Receptor Activity Regulation Of Immune Response Immune System Process Innate Immune Response Activating Cell Surface Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Membrane Regulation Of Innate Immune Response Regulation Of Immune System Process Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Beta Selection Positive Regulation Of Immune Effector Process Immune Response-regulating Cell Surface Receptor Signaling Pathway Positive Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Lymphocyte Mediated Immunity Immune Response-activating Signaling Pathway Positive Regulation Of Immune System Process Cellular Defense Response Regulation Of Cell Activation Signal Transduction Regulation Of Natural Killer Cell Mediated Cytotoxicity Positive Regulation Of Immune Response Carbohydrate Binding Innate Immune Response-activating Signaling Pathway Positive Regulation Of Cell Activation Positive Regulation Of Calcium-mediated Signaling Regulation Of Natural Killer Cell Mediated Immunity Plasma Membrane Activation Of Immune Response Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Activation Of Innate Immune Response Positive Regulation Of Cell Killing Immune Response Scaffold Protein Binding Positive Regulation Of Defense Response Lymphocyte Activation Regulation Of Defense Response Regulation Of Lymphocyte Activation Positive Regulation Of T Cell Activation Defense Response Regulation Of Calcium-mediated Signaling Signaling Receptor Activity Regulation Of Leukocyte Mediated Cytotoxicity Leukocyte Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Phagocytosis Adaptive Immune Response