KIR3DS1 and KIR3DL1

Data Source: HiPPIP (Novel)

		KIR3DS1	KIR3DL1
Name		killer cell immunoglobulin like receptor, three Ig domains and short cytoplasmic tail 1	killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1
Structure		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Membrane
	Molecular Function	Protein Binding MHC Class I Receptor Activity	Amyloid-beta Binding Protein Binding HLA-B Specific Inhibitory MHC Class I Receptor Activity Molecular Adaptor Activity
	Biological Process	Immune Response-regulating Signaling Pathway Immune Response Natural Killer Cell Activation	Immune Response-regulating Signaling Pathway Immune Response Natural Killer Cell Mediated Cytotoxicity
Pathways		DAP12 interactions	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
GWAS		No GWAS studies recorded	Lymphocyte count ( 32888494 ) Ulcerative colitis ( 28067908 )
Novel Interactors		2 novel interactors: KIR3DL1 LAIR1	4 novel interactors: FPR1 KIR2DS1 KIR2DS5 KIR3DS1
Interacting Genes		2 interacting genes: HLA-B TYROBP	7 interacting genes: BMP10 CDK3 HLA-B RPS6KB1 SMCO4 TAFA2 THSD7B
Entrez ID		3813	3811
HPRD ID		10034	09226
Ensembl ID		Not available	ENSG00000167633
Uniprot IDs		A0A0G2JN05 O43469 Q14943 Q4KN23 Q99565	P43629 Q5UCE2 Q6H2G3 Q8N6C9
PDB IDs		Not available	3VH8 3WUW 5B38 5B39 5T6Z 5T70 6V3J 7K80 7K81 9BL2 9BL3 9BL4 9BL5 9BL6 9BL9 9BLA
GO Terms Enriched among Interactors		Regulation Of Immune Response Immune Response Natural Killer Cell Mediated Immunity Positive Regulation Of Leukocyte Mediated Cytotoxicity Regulation Of Immune System Process Positive Regulation Of Cell Killing Immune Response-regulating Signaling Pathway Immune System Process Innate Immune Response Secretory Granule Membrane Regulation Of Leukocyte Mediated Cytotoxicity Lymphocyte Mediated Immunity Defense Response To Other Organism Defense Response To Symbiont Regulation Of Interleukin-6 Production HLA-B Specific Inhibitory MHC Class I Receptor Activity Leukocyte Mediated Immunity Stimulatory Killer Cell Immunoglobulin-like Receptor Signaling Pathway TAP Binding Molecular Adaptor Activity Positive Regulation Of Osteoclast Development Positive Regulation Of Microglial Cell Mediated Cytotoxicity Positive Regulation Of Receptor Localization To Synapse Positive Regulation Of Macrophage Fusion Response To Other Organism Microglial Cell Activation Involved In Immune Response Positive Regulation Of Immune Effector Process Protection From Natural Killer Cell Mediated Cytotoxicity Negative Regulation Of Transforming Growth Factor Beta1 Production Defense Response Response To External Biotic Stimulus Adaptive Immune Response Regulation Of T Cell Anergy T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell MHC Class I Protein Complex Regulation Of Osteoclast Development Detection Of Bacterium Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class I Via ER Pathway, TAP-independent Regulation Of T Cell Tolerance Induction Immune Effector Process Neutrophil Activation Involved In Immune Response Negative Regulation Of Long-term Synaptic Potentiation Negative Regulation Of Transforming Growth Factor Beta Production Signaling Receptor Binding Antigen Processing And Presentation Of Endogenous Peptide Antigen Via MHC Class Ib Regulation Of Hemopoiesis Regulation Of Dendritic Cell Differentiation Regulation Of Innate Immune Response Negative Regulation Of B Cell Proliferation Regulation Of Tolerance Induction	Regulation Of Immune Response Immune Response-regulating Signaling Pathway